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MX2017014641A - Composiciones y metodos para inhibir la expresion del gen de factor inducible por hipoxia alfa (hif2alfa). - Google Patents

Composiciones y metodos para inhibir la expresion del gen de factor inducible por hipoxia alfa (hif2alfa).

Info

Publication number
MX2017014641A
MX2017014641A MX2017014641A MX2017014641A MX2017014641A MX 2017014641 A MX2017014641 A MX 2017014641A MX 2017014641 A MX2017014641 A MX 2017014641A MX 2017014641 A MX2017014641 A MX 2017014641A MX 2017014641 A MX2017014641 A MX 2017014641A
Authority
MX
Mexico
Prior art keywords
gene expression
rnai
compositions
hif2alpha
methods
Prior art date
Application number
MX2017014641A
Other languages
English (en)
Inventor
H Wakefield Darren
B Rozema David
L Lewis David
Wong So
V Blokhin Andrei
C Carlson Jeffrey
D Benson Jonathan
B Kanner Steven
J Almeida Lauren
Chen Weijun
L Nicholas Anthony
Almeida Aaron
WOODS Justin
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of MX2017014641A publication Critical patent/MX2017014641A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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Abstract

Se describen activadores de ARN de interferencia (ARNi) y conjugados de activado de ARNi para inhibir la expresión del gen para Hif2a (EPAS1). También se describen composiciones farmacéuticas que comprenden uno o más activadores de ARNi para HifZa opcionalmente con una o más sustancias terapéuticas adicionales. El suministro de los activadores de ARNi para Hif2a descritos a células tumores in vivo proporciona inhibición de la expresión del gen para Hif2a y tratamiento contra el cáncer.
MX2017014641A 2015-05-29 2016-05-27 Composiciones y metodos para inhibir la expresion del gen de factor inducible por hipoxia alfa (hif2alfa). MX2017014641A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562168244P 2015-05-29 2015-05-29
PCT/US2016/034512 WO2016196239A1 (en) 2015-05-29 2016-05-27 Compositions and methods for inhibiting gene expression of hif2alpha

Publications (1)

Publication Number Publication Date
MX2017014641A true MX2017014641A (es) 2018-01-23

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ID=57397333

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Application Number Title Priority Date Filing Date
MX2017014641A MX2017014641A (es) 2015-05-29 2016-05-27 Composiciones y metodos para inhibir la expresion del gen de factor inducible por hipoxia alfa (hif2alfa).

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Country Link
US (3) US9976141B2 (es)
EP (1) EP3302503A4 (es)
JP (3) JP7021076B2 (es)
KR (1) KR20180011198A (es)
CN (2) CN114601845A (es)
AR (1) AR104754A1 (es)
AU (2) AU2016270593B2 (es)
BR (1) BR112017025698A2 (es)
CA (1) CA2984498C (es)
EA (1) EA201792103A1 (es)
HK (1) HK1252852A1 (es)
IL (1) IL255998A (es)
MX (1) MX2017014641A (es)
SG (1) SG10202105989WA (es)
TW (1) TWI761305B (es)
WO (1) WO2016196239A1 (es)
ZA (1) ZA201707148B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI761305B (zh) * 2015-05-29 2022-04-21 美商愛羅海德製藥公司 抑制Ｈｉｆ２α基因表現之組合物及方法
JOP20210043A1 (ar) 2015-10-01 2017-06-16 Arrowhead Pharmaceuticals Inc تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
KR102609396B1 (ko) * 2017-10-13 2023-12-01 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Ldha의 발현을 억제하기 위한 방법 및 조성물
BR112020006901A2 (pt) 2017-11-01 2020-10-13 Arrowhead Pharmaceuticals, Inc. ligantes de integrina e usos dos mesmos
IL309955A (en) 2018-04-27 2024-03-01 Arrowhead Pharmaceuticals Inc Integrin-targeting ligands and their uses
WO2019210308A1 (en) 2018-04-27 2019-10-31 Arrowhead Pharmaceuticals, Inc. Integrin targeting ligands and uses thereof
CA3120580A1 (en) 2019-01-09 2020-07-16 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use
WO2022086882A1 (en) 2020-10-21 2022-04-28 Nikang Therapeutics, Inc. Diagnostic and therapeutic methods for treatment of cancer with a hif-2(alpha) inhibitor
MX2023011909A (es) 2021-04-08 2023-10-18 Arrowhead Pharmaceuticals Inc Agentes de rnai para inhibir la expresion del receptor para productos finales de glicacion avanzada, composiciones de estos y metodos de uso.
JPWO2023038027A1 (es) * 2021-09-07 2023-03-16
CN114106012B (zh) * 2021-12-13 2023-05-23 宜昌博仁凯润药业有限公司 一种化合物Biotin-PEG3-SS-DBCO制备方法及其应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU767195B2 (en) 1999-03-10 2003-11-06 Phogen Limited Delivery of substances to cells
US20080188430A1 (en) * 2001-05-18 2008-08-07 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
CA2506714A1 (en) * 2002-11-26 2004-06-10 University Of Massachusetts Delivery of sirnas
WO2005089287A2 (en) 2004-03-15 2005-09-29 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded rna
WO2008022309A2 (en) 2006-08-18 2008-02-21 F. Hoffmann-La Roche Ag Polyconjugates for in vivo delivery of polynucleotides
ES2462416T3 (es) * 2007-08-06 2014-05-22 Senju Pharmaceutical Co., Ltd. Producto farmacéutico que contiene un inhibidor de la expresión de HIF-1 alfa y HIF-2 alfa
CA2718942A1 (en) * 2008-03-18 2009-09-24 Seattle Genetics, Inc. Auristatin drug linker conjugates
WO2009123764A2 (en) * 2008-04-04 2009-10-08 Calando Pharmaceuticals, Inc. Compositions and use of epas1 inhibitors
AU2009336191B2 (en) 2008-12-18 2017-08-24 Novo Nordisk A/S Extended dicer substrate agents and methods for the specific inhibition of gene expression
WO2010093788A2 (en) 2009-02-11 2010-08-19 Dicerna Pharmaceuticals, Inc. Multiplex dicer substrate rna interference molecules having joining sequences
RS54578B1 (sr) 2010-02-24 2016-06-30 Arrowhead Research Corporation Preparati za ciljano dopremanje sirnk
KR101223660B1 (ko) * 2010-05-20 2013-01-17 광주과학기술원 ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
JP2014504295A (ja) * 2010-12-17 2014-02-20 アローヘッド リサーチ コーポレイション ｓｉＲＮＡ用ガラクトースクラスター−薬物動態調節剤標的指向部分
US8501930B2 (en) 2010-12-17 2013-08-06 Arrowhead Madison Inc. Peptide-based in vivo siRNA delivery system
CN103282503B (zh) 2010-12-29 2015-12-02 弗·哈夫曼-拉罗切有限公司 用于细胞内递送核酸的小分子缀合物
WO2012174224A2 (en) * 2011-06-17 2012-12-20 Calando Pharmaceuticals, Inc. Methods for administering nucleic acid-based therapeutics
CN104024328A (zh) 2011-08-26 2014-09-03 箭头研究公司 用于体内核酸递送的聚(乙烯基酯)聚合物
BR112014004528A2 (pt) 2012-04-18 2019-09-24 Arrowhead Res Corp polímeros de poli(acrilato) para entrega de ácido nucleico in vivo
SG11201506805QA (en) * 2013-02-28 2015-09-29 Arrowhead Res Corp Organic compositions to treat epas1-related diseases
KR20160035081A (ko) * 2013-08-07 2016-03-30 애로우헤드 리서치 코오포레이션 생체 내에서 RNAi 유발제를 종양 세포로 전달하기 위한 폴리콘주게이트
WO2016149020A1 (en) * 2015-03-17 2016-09-22 Arrowhead Research Corporation Rna interference agents
TWI761305B (zh) * 2015-05-29 2022-04-21 美商愛羅海德製藥公司 抑制Ｈｉｆ２α基因表現之組合物及方法

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