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MX2017014033A - Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones viricas. - Google Patents

Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones viricas.

Info

Publication number
MX2017014033A
MX2017014033A MX2017014033A MX2017014033A MX2017014033A MX 2017014033 A MX2017014033 A MX 2017014033A MX 2017014033 A MX2017014033 A MX 2017014033A MX 2017014033 A MX2017014033 A MX 2017014033A MX 2017014033 A MX2017014033 A MX 2017014033A
Authority
MX
Mexico
Prior art keywords
prophylaxis
derivatives
novel
treatment
compounds
Prior art date
Application number
MX2017014033A
Other languages
English (en)
Other versions
MX376761B (es
Inventor
Yun Hongying
Zheng Xiufang
Wang Jianping
Liang Chungen
Miao Kun
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55910966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017014033(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2017014033A publication Critical patent/MX2017014033A/es
Publication of MX376761B publication Critical patent/MX376761B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I), Ver fórmula (I), en la que R1, R2 y R3 son como se han descrito en el presente documento, y sus profármacos o sales, enantiómeros o diastereómeros farmacéuticamente aceptables de los mismos, y composiciones que incluyen los compuestos y métodos para usar los compuestos.
MX2017014033A 2015-05-08 2016-05-04 Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones víricas. MX376761B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2015078507 2015-05-08
CN2016078785 2016-04-08
PCT/EP2016/059961 WO2016180695A1 (en) 2015-05-08 2016-05-04 Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection

Publications (2)

Publication Number Publication Date
MX2017014033A true MX2017014033A (es) 2018-03-01
MX376761B MX376761B (es) 2025-03-07

Family

ID=55910966

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020010949A MX393198B (es) 2015-05-08 2016-05-04 Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones viricas
MX2017014033A MX376761B (es) 2015-05-08 2016-05-04 Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones víricas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020010949A MX393198B (es) 2015-05-08 2016-05-04 Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones viricas

Country Status (32)

Country Link
US (3) US9708325B2 (es)
EP (1) EP3294740B1 (es)
JP (1) JP6738352B2 (es)
KR (1) KR102690131B1 (es)
CN (1) CN107580596B (es)
AR (1) AR104528A1 (es)
AU (3) AU2016260683B2 (es)
BR (1) BR112017023959B1 (es)
CA (1) CA2982704C (es)
CL (1) CL2017002745A1 (es)
CO (1) CO2017009994A2 (es)
CR (1) CR20170496A (es)
DK (1) DK3294740T3 (es)
ES (1) ES2753777T3 (es)
HR (1) HRP20191942T1 (es)
HU (1) HUE045906T2 (es)
IL (2) IL254947B (es)
LT (1) LT3294740T (es)
MX (2) MX393198B (es)
MY (1) MY182353A (es)
NZ (2) NZ735648A (es)
PE (1) PE20171620A1 (es)
PH (1) PH12017502009A1 (es)
PL (1) PL3294740T3 (es)
PT (1) PT3294740T (es)
RS (1) RS59435B1 (es)
RU (1) RU2745269C2 (es)
SG (1) SG10202108841YA (es)
SI (1) SI3294740T1 (es)
TW (2) TWI706954B (es)
UA (1) UA120450C2 (es)
WO (1) WO2016180695A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102690131B1 (ko) 2015-05-08 2024-07-31 에프. 호프만-라 로슈 아게 바이러스 감염의 치료 및 예방을 위한 신규한 설폰이미도일푸린온 화합물 및 유도체
PT3504210T (pt) 2016-08-29 2021-04-19 H Hoffnabb La Roche Ag Compostos de sulfonimidoílpurinona 7-substituídos para o tratamento e profilaxia de infeção por vírus
CN109715214B (zh) * 2016-09-13 2022-03-04 豪夫迈·罗氏有限公司 Tlr7激动剂和hbv衣壳组装抑制剂的组合治疗
JP7328977B2 (ja) 2018-02-12 2023-08-17 エフ． ホフマン－ラ ロシュ アーゲー ウイルス感染の処置および予防のための新規のスルホン化合物および誘導体
CN111801100B (zh) * 2018-02-28 2023-10-24 豪夫迈·罗氏有限公司 用于治疗和预防肝癌的7-取代的磺亚氨酰基嘌呤酮化合物和衍生物
CN111072667A (zh) * 2018-10-22 2020-04-28 罗欣药业(上海)有限公司 五元或六元杂环并嘧啶类化合物及其用途
CA3128081A1 (en) * 2019-02-12 2020-08-20 Ambrx, Inc. Compositions containing, methods and uses of antibody-tlr agonist conjugates
WO2021053110A1 (en) 2019-09-20 2021-03-25 Syngenta Crop Protection Ag Pesticidally active heterocyclic derivatives with sulfur and sulfoximine containing substituents
CN115643805B (zh) * 2020-01-27 2024-11-08 百时美施贵宝公司 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物
EP4097105A1 (en) * 2020-01-27 2022-12-07 Bristol-Myers Squibb Company 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists
JP2025522978A (ja) 2022-07-14 2025-07-17 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト がんの処置のためのホスホリルプリノン化合物
CN118724963A (zh) * 2023-03-30 2024-10-01 浙江养生堂天然药物研究所有限公司 含磷或含硫的大环化合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4189048B2 (ja) * 1997-12-26 2008-12-03 大日本住友製薬株式会社 複素環化合物
AU2006242920A1 (en) 2005-05-04 2006-11-09 Pfizer Limited 2-amido-6-amino-8-oxopurine derivatives as Toll-Like receptor modulators for the treatment of cancer and viral infections, such as hepatitis C
CN101239980B (zh) 2008-02-18 2011-06-22 靳广毅 免疫受体调节剂偶联体前体和偶联体及其应用
TW201639852A (zh) * 2008-12-09 2016-11-16 吉李德科學股份有限公司 用於製備可用作類鐸受體調節劑之化合物的中間體化合物
US20110150836A1 (en) 2009-12-22 2011-06-23 Gilead Sciences, Inc. Methods of treating hbv and hcv infection
TWI555737B (zh) * 2011-05-24 2016-11-01 拜耳知識產權公司 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺
EA036645B1 (ru) 2011-11-09 2020-12-03 Янссен Сайенсиз Айрлэнд Юси Производные пурина для лечения вирусных инфекций
PL2978429T3 (pl) 2013-03-29 2017-08-31 Janssen Sciences Ireland Uc Deazapurynony makrocykliczne do leczenia infekcji wirusowych
SI3190113T1 (sl) 2014-08-15 2021-09-30 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Pirolopirimidinske spojine, ki se uporabljajo kot agonist TLR7
KR102690131B1 (ko) * 2015-05-08 2024-07-31 에프. 호프만-라 로슈 아게 바이러스 감염의 치료 및 예방을 위한 신규한 설폰이미도일푸린온 화합물 및 유도체
PT3504210T (pt) * 2016-08-29 2021-04-19 H Hoffnabb La Roche Ag Compostos de sulfonimidoílpurinona 7-substituídos para o tratamento e profilaxia de infeção por vírus

Also Published As

Publication number Publication date
IL254947B (en) 2021-02-28
CL2017002745A1 (es) 2018-05-18
RU2745269C2 (ru) 2021-03-22
IL280769A (en) 2021-04-29
AU2022204666A1 (en) 2022-07-21
KR20180003612A (ko) 2018-01-09
PE20171620A1 (es) 2017-11-02
JP2018515509A (ja) 2018-06-14
NZ775222A (en) 2024-09-27
AU2020256348B2 (en) 2022-06-16
KR102690131B1 (ko) 2024-07-31
BR112017023959B1 (pt) 2023-05-02
US9708325B2 (en) 2017-07-18
NZ735648A (en) 2023-06-30
TW202108584A (zh) 2021-03-01
CA2982704A1 (en) 2016-11-17
UA120450C2 (uk) 2019-12-10
HK1247925A1 (zh) 2018-10-05
EP3294740A1 (en) 2018-03-21
TW201716410A (zh) 2017-05-16
LT3294740T (lt) 2019-11-25
TWI768467B (zh) 2022-06-21
IL254947A0 (en) 2017-12-31
JP6738352B2 (ja) 2020-08-12
PT3294740T (pt) 2019-10-29
WO2016180695A1 (en) 2016-11-17
RU2017142577A3 (es) 2019-10-31
CO2017009994A2 (es) 2018-02-20
CA2982704C (en) 2023-10-24
TWI706954B (zh) 2020-10-11
RS59435B1 (sr) 2019-11-29
AU2020256348A1 (en) 2020-11-12
MX376761B (es) 2025-03-07
HUE045906T2 (hu) 2020-01-28
RU2017142577A (ru) 2019-06-10
AU2016260683A1 (en) 2017-10-12
SG10202108841YA (en) 2021-09-29
AU2016260683B2 (en) 2020-10-29
DK3294740T3 (da) 2019-11-04
US20160326177A1 (en) 2016-11-10
CN107580596B (zh) 2020-07-14
AR104528A1 (es) 2017-07-26
PL3294740T3 (pl) 2020-03-31
US10399983B2 (en) 2019-09-03
MY182353A (en) 2021-01-20
IL280769B1 (en) 2023-03-01
EP3294740B1 (en) 2019-09-04
CN107580596A (zh) 2018-01-12
US11242345B2 (en) 2022-02-08
SI3294740T1 (sl) 2019-12-31
PH12017502009A1 (en) 2018-03-26
HRP20191942T1 (hr) 2020-01-10
BR112017023959A2 (pt) 2018-07-17
IL280769B2 (en) 2023-07-01
US20200109144A1 (en) 2020-04-09
MX2020010949A (es) 2022-06-16
US20170275286A1 (en) 2017-09-28
CR20170496A (es) 2017-12-05
MX393198B (es) 2025-03-19
ES2753777T3 (es) 2020-04-14

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