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MX2017013177A - Anticuerpo anti-vegfr2 humano para terapia del cancer anti-angiogenica y dirigida. - Google Patents

Anticuerpo anti-vegfr2 humano para terapia del cancer anti-angiogenica y dirigida.

Info

Publication number
MX2017013177A
MX2017013177A MX2017013177A MX2017013177A MX2017013177A MX 2017013177 A MX2017013177 A MX 2017013177A MX 2017013177 A MX2017013177 A MX 2017013177A MX 2017013177 A MX2017013177 A MX 2017013177A MX 2017013177 A MX2017013177 A MX 2017013177A
Authority
MX
Mexico
Prior art keywords
vegfr2
domain
angiogenic
human antibody
cancer therapy
Prior art date
Application number
MX2017013177A
Other languages
English (en)
Other versions
MX388174B (es
Inventor
Min Lu Ruei-
Yi Chiu Chiung-
Ling Chang Yu-
Chung WU Han-
Ju LIU I-
Original Assignee
Academia Sinica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academia Sinica filed Critical Academia Sinica
Publication of MX2017013177A publication Critical patent/MX2017013177A/es
Publication of MX388174B publication Critical patent/MX388174B/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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Abstract

Se describe un anticuerpo aislado o un fragmento de unión de antígeno del mismo que tiene una afinidad de unión específica aun epitopo localizado dentro del dominio 1 o dominio 3 del receptor del crecimiento endotelial vascular humano 2 (VEGFR2; SEQ ID NO: 74). El epitopo dentro del dominio 3 del VEGFR2 se localiza entre los residuos de aminoácido 250 y 270 de la SEQ ID NO: 74. También se describe el uso del anticuerpo o fragmento de unión de antígeno del mismo en la preparación de un medicamento para inhibir el crecimiento tumoral, angiogénesis tumoral, y/o inducir citotoxicidad en células cancerosas en un sujeto que necesite de lo mismo. También se describe un método para detectar la presencia de VEGFR2 en una célula endotelial tumoral vascular o una célula cancerosa en una muestra biológica.
MX2017013177A 2015-04-14 2016-04-12 Anticuerpo anti-vegfr2 humano para terapia del cancer anti-angiogenica y dirigida MX388174B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562147344P 2015-04-14 2015-04-14
PCT/US2016/027057 WO2016168159A1 (en) 2015-04-14 2016-04-12 Anti-vegfr2 human antibody for anti-angiogenic and targeted cancer therapy

Publications (2)

Publication Number Publication Date
MX2017013177A true MX2017013177A (es) 2018-01-30
MX388174B MX388174B (es) 2025-03-19

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MX2017013177A MX388174B (es) 2015-04-14 2016-04-12 Anticuerpo anti-vegfr2 humano para terapia del cancer anti-angiogenica y dirigida

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US (1) US10196447B2 (es)
EP (1) EP3283528B1 (es)
JP (1) JP6542383B2 (es)
KR (1) KR20170135904A (es)
CN (1) CN107531789B (es)
AU (1) AU2016249991B2 (es)
BR (1) BR112017022205A2 (es)
CA (1) CA2981883C (es)
ES (1) ES2882276T3 (es)
MX (1) MX388174B (es)
NZ (1) NZ735720A (es)
PT (1) PT3283528T (es)
SG (1) SG11201707949XA (es)
TW (1) TWI621629B (es)
WO (1) WO2016168159A1 (es)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
KR102725051B1 (ko) 2015-09-23 2024-11-04 제넨테크, 인크. 항-vegf 항체의 최적화된 변이체들
CN106674349B (zh) * 2017-03-07 2018-03-13 北京东方百泰生物科技有限公司 一种改进的抗vegfr‑2单克隆抗体
GB201710836D0 (en) * 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Car T-Cells
WO2021013061A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 一种人源化抗vegfr2抗体及其应用
AU2020366222B2 (en) * 2019-10-17 2024-10-10 National Health Research Institutes Use of succinate as biomarker in diagnosis and treatment of cancers
KR20230039943A (ko) * 2021-09-15 2023-03-22 주식회사 파멥신 항-vegfr2(kdr) 개량 항체 및 이의 용도

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US6811779B2 (en) * 1994-02-10 2004-11-02 Imclone Systems Incorporated Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
WO2002020008A1 (en) 2000-09-06 2002-03-14 The Scripps Research Institute Inhibitors of nadh:ubiquinone oxidoreductase
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
KR100883430B1 (ko) * 2007-06-13 2009-02-12 한국생명공학연구원 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도
US8975377B2 (en) * 2007-08-13 2015-03-10 Vasgene Therapeutics, Inc Cancer treatment using humanized antibodies that bind to EphB4
SG188324A1 (en) * 2010-09-03 2013-04-30 Academia Sinica Anti-c-met antibody and methods of use thereof
ES2966030T3 (es) 2012-10-05 2024-04-18 Kadmon Corp Llc Anticuerpos anti-VEGFR-2/KDR humanos

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PT3283528T (pt) 2021-08-11
US20180127504A1 (en) 2018-05-10
CN107531789B (zh) 2021-08-10
JP2018512434A (ja) 2018-05-17
EP3283528A1 (en) 2018-02-21
JP6542383B2 (ja) 2019-07-10
CN107531789A (zh) 2018-01-02
AU2016249991B2 (en) 2021-03-25
WO2016168159A1 (en) 2016-10-20
BR112017022205A2 (pt) 2018-08-28
EP3283528B1 (en) 2021-07-21
CA2981883A1 (en) 2016-10-20
EP3283528A4 (en) 2019-03-06
CA2981883C (en) 2019-10-22
ES2882276T3 (es) 2021-12-01
NZ735720A (en) 2024-07-05
TWI621629B (zh) 2018-04-21
SG11201707949XA (en) 2017-10-30
TW201712033A (zh) 2017-04-01
MX388174B (es) 2025-03-19
AU2016249991A1 (en) 2017-10-12
US10196447B2 (en) 2019-02-05
KR20170135904A (ko) 2017-12-08

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