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MX2017012223A - Metodo de produccion con iones de cobre controlados. - Google Patents

Metodo de produccion con iones de cobre controlados.

Info

Publication number
MX2017012223A
MX2017012223A MX2017012223A MX2017012223A MX2017012223A MX 2017012223 A MX2017012223 A MX 2017012223A MX 2017012223 A MX2017012223 A MX 2017012223A MX 2017012223 A MX2017012223 A MX 2017012223A MX 2017012223 A MX2017012223 A MX 2017012223A
Authority
MX
Mexico
Prior art keywords
medium
production method
copper ions
initial medium
controlled copper
Prior art date
Application number
MX2017012223A
Other languages
English (en)
Other versions
MX390879B (es
Inventor
Yamamoto Seiko
Doi Hiroyuki
Terashima Isamu
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2017012223A publication Critical patent/MX2017012223A/es
Publication of MX390879B publication Critical patent/MX390879B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona un método de cultivo celular que comprende añadir un medio para siembra que contiene células a un medio inicial y comenzar a cultivar la célula en el medio inicial, en donde el medio inicial tiene un aditivo de medio de cultivo obtenido de organismos añadido al mismo y la cantidad de las especies amidadas C-terminal en la proteína producida es controlada por el contenido de cobre del medio inicial al inicio del cultivo de células.
MX2017012223A 2015-03-26 2016-03-25 Metodo de produccion con iones de cobre controlados. MX390879B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015063662 2015-03-26
PCT/JP2016/059634 WO2016153041A1 (ja) 2015-03-26 2016-03-25 銅イオン制御製造方法

Publications (2)

Publication Number Publication Date
MX2017012223A true MX2017012223A (es) 2018-01-30
MX390879B MX390879B (es) 2025-03-21

Family

ID=56977504

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017012223A MX390879B (es) 2015-03-26 2016-03-25 Metodo de produccion con iones de cobre controlados.
MX2022003016A MX2022003016A (es) 2015-03-26 2017-09-25 Metodo de produccion con iones de cobre controlados.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022003016A MX2022003016A (es) 2015-03-26 2017-09-25 Metodo de produccion con iones de cobre controlados.

Country Status (13)

Country Link
US (2) US11046772B2 (es)
EP (2) EP3276001B1 (es)
JP (1) JP6752776B2 (es)
CN (1) CN107406832A (es)
AR (1) AR104050A1 (es)
AU (2) AU2016237086B2 (es)
BR (1) BR112017020401B1 (es)
CA (1) CA2980695A1 (es)
IL (1) IL254668B (es)
MX (2) MX390879B (es)
SG (1) SG11201707873TA (es)
TW (1) TWI716392B (es)
WO (1) WO2016153041A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
DK2493922T3 (en) 2009-10-26 2017-04-24 Hoffmann La Roche Process for preparing a glycosylated immunoglobulin
KR20220070586A (ko) 2010-11-08 2022-05-31 제넨테크, 인크. 피하 투여용 항―ｉｌ―6 수용체 항체
AR104050A1 (es) * 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados
EP3971201A4 (en) * 2019-05-15 2023-11-22 Sekisui Chemical Co., Ltd. CELL GROWING SCAFFOLD MATERIAL AND CELL GROWING CONTAINER

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW205553B (es) 1991-04-25 1993-05-11 Chugai Pharmaceutical Co Ltd
JP3630453B2 (ja) 1994-09-30 2005-03-16 中外製薬株式会社 Ｉｌ−６レセプター抗体を有効成分とする未熟型骨髄腫細胞治療剤
JP3822137B2 (ja) 2002-05-20 2006-09-13 中外製薬株式会社 動物細胞培養用培地の添加剤およびそれを用いたタンパク質の製造方法
EP1728801A4 (en) 2004-03-24 2009-10-21 Chugai Pharmaceutical Co Ltd SUBTYP OF A HUMANIZED ANTIBODY AGAINST THE INTERLEUKIN-6 RECEPTOR
JP4818936B2 (ja) * 2005-01-05 2011-11-16 中外製薬株式会社 細胞の培養方法およびその利用
US9012180B2 (en) 2007-03-02 2015-04-21 Wyeth Llc Use of copper and glutamate in cell culture for production of polypeptides
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
DK2493922T3 (en) * 2009-10-26 2017-04-24 Hoffmann La Roche Process for preparing a glycosylated immunoglobulin
CN103097522A (zh) 2010-07-08 2013-05-08 巴克斯特国际公司 在细胞培养物中生产重组adamts13的方法
WO2013012022A1 (ja) * 2011-07-19 2013-01-24 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
JP2016513478A (ja) * 2013-03-15 2016-05-16 ジェネンテック， インコーポレイテッド 細胞培養培地及び抗体を産生する方法
US10196601B2 (en) * 2013-08-20 2019-02-05 Lek Pharmaceuticals D.D. Cell culture medium and process for controlling α-amidation and/or C-terminal amino acid cleavage of polypeptides
KR20160138477A (ko) 2014-03-23 2016-12-05 어드밴텍 바이오사이언스 파마큐티카 엘티디에이 구리를 이용한 재조합 단백질의 발현 증가 방법
AR104050A1 (es) * 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados

Also Published As

Publication number Publication date
AU2016237086B2 (en) 2022-04-14
AR104050A1 (es) 2017-06-21
AU2022204600B2 (en) 2024-10-17
IL254668B (en) 2021-01-31
AU2022204600A1 (en) 2022-07-21
WO2016153041A1 (ja) 2016-09-29
IL254668A0 (en) 2017-11-30
US20210269536A1 (en) 2021-09-02
MX2022003016A (es) 2022-04-07
EP3276001A4 (en) 2018-09-12
AU2016237086A1 (en) 2017-10-19
EP4219694A1 (en) 2023-08-02
SG11201707873TA (en) 2017-10-30
EP3276001B1 (en) 2025-05-07
TWI716392B (zh) 2021-01-21
MX390879B (es) 2025-03-21
CN107406832A (zh) 2017-11-28
CA2980695A1 (en) 2016-09-29
JPWO2016153041A1 (ja) 2018-01-18
US11046772B2 (en) 2021-06-29
JP6752776B2 (ja) 2020-09-09
EP3276001C0 (en) 2025-05-07
US20180051090A1 (en) 2018-02-22
TW201708532A (zh) 2017-03-01
BR112017020401B1 (pt) 2021-04-06
EP3276001A1 (en) 2018-01-31
BR112017020401A2 (pt) 2018-06-05

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