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MX2017002877A - Compuestos terapeuticos como inhibidores del receptor de orexina-1. - Google Patents

Compuestos terapeuticos como inhibidores del receptor de orexina-1.

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Publication number
MX2017002877A
MX2017002877A MX2017002877A MX2017002877A MX2017002877A MX 2017002877 A MX2017002877 A MX 2017002877A MX 2017002877 A MX2017002877 A MX 2017002877A MX 2017002877 A MX2017002877 A MX 2017002877A MX 2017002877 A MX2017002877 A MX 2017002877A
Authority
MX
Mexico
Prior art keywords
orexin
receptor
inhibitors
therapeutic compounds
compounds
Prior art date
Application number
MX2017002877A
Other languages
English (en)
Inventor
Louise Blaney Emma
Phillip Martin Barrie
Nowak Thorsten
John Watson Martin
Original Assignee
C4X Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C4X Discovery Ltd filed Critical C4X Discovery Ltd
Publication of MX2017002877A publication Critical patent/MX2017002877A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

La presente invención se refiere a compuestos que son inhibidores del receptor de orexina-1. Los compuestos tienen la fórmula estructural I definida en la presente. La presente invención también se refiere a procesos para la preparación de estos compuestos, a composiciones farmacéuticas que los comprenden, y a su uso en el tratamiento de las enfermedades o los trastornos asociados con la actividad del receptor de orexina-1. (ver Fórmula).
MX2017002877A 2014-09-03 2015-09-03 Compuestos terapeuticos como inhibidores del receptor de orexina-1. MX2017002877A (es)

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PCT/GB2015/052546 WO2016034882A1 (en) 2014-09-03 2015-09-03 Therapeutic compounds as inhibitors of the orexin-1 receptor

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