MX2017001869A - Formas cristalinas de un modulador de receptor de estrogeno. - Google Patents
Formas cristalinas de un modulador de receptor de estrogeno.Info
- Publication number
- MX2017001869A MX2017001869A MX2017001869A MX2017001869A MX2017001869A MX 2017001869 A MX2017001869 A MX 2017001869A MX 2017001869 A MX2017001869 A MX 2017001869A MX 2017001869 A MX2017001869 A MX 2017001869A MX 2017001869 A MX2017001869 A MX 2017001869A
- Authority
- MX
- Mexico
- Prior art keywords
- estrogen receptor
- receptor modulator
- crystalline forms
- modulator
- indazol
- Prior art date
Links
- 239000002834 estrogen receptor modulator Substances 0.000 title abstract 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000015694 estrogen receptors Human genes 0.000 abstract 1
- 108010038795 estrogen receptors Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
En el presente documento se describen formas amorfas y cristalinas de sales farmaceuticamente aceptables del modulador de receptor de estrogeno acido (E)-3-(4-((E)-2-(2- cloro-4-fluorofenil)-1-(1H-indazol-5-il)but-1-en-1- il)fenil)acrilico. Tambien se describen composiciones farmaceuticas adecuadas para la administracion a un mamifero que incluyen el modulador de receptor de estrogeno, y metodos de uso del modulador de receptor de estrogeno, solo y en combinacion con otros compuestos, para tratar enfermedades o afecciones que estan asociadas con la actividad de receptor de estrogeno.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462036015P | 2014-08-11 | 2014-08-11 | |
| PCT/EP2015/068327 WO2016023847A1 (en) | 2014-08-11 | 2015-08-10 | Crystalline forms of an estrogen receptor modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017001869A true MX2017001869A (es) | 2017-05-17 |
Family
ID=54011696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017001869A MX2017001869A (es) | 2014-08-11 | 2015-08-10 | Formas cristalinas de un modulador de receptor de estrogeno. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9783503B2 (es) |
| EP (1) | EP3180316A1 (es) |
| JP (1) | JP2017524009A (es) |
| KR (1) | KR20170040251A (es) |
| CN (1) | CN106660969A (es) |
| AR (1) | AR101487A1 (es) |
| AU (1) | AU2015303297A1 (es) |
| BR (1) | BR112016029604A2 (es) |
| CA (1) | CA2949329A1 (es) |
| IL (1) | IL249160A0 (es) |
| MX (1) | MX2017001869A (es) |
| RU (1) | RU2017105840A (es) |
| SG (1) | SG11201700995WA (es) |
| WO (1) | WO2016023847A1 (es) |
| ZA (1) | ZA201608000B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9975856B2 (en) | 2015-10-07 | 2018-05-22 | Genentech, Inc. | Process for the preparation of (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid |
| CN107973780B (zh) * | 2016-10-21 | 2020-10-09 | 四川科伦博泰生物医药股份有限公司 | 一种取代的烯烃类化合物及其制备方法和用途 |
| CN113166056B (zh) * | 2018-11-28 | 2024-07-05 | 罗欣药业(上海)有限公司 | 一种雌激素受体下调剂的盐型、晶型及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1667791A1 (en) * | 2003-10-06 | 2006-06-14 | Solvias AG | Process for the parallel detection of crystalline forms of molecular solids |
| GB2483736B (en) * | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| NZ630124A (en) | 2012-03-20 | 2016-01-29 | Seragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| CA2899969A1 (en) | 2013-03-14 | 2014-09-25 | Seragon Pharmaceuticals, Inc. | Polycyclic estrogen receptor modulators and uses thereof |
| CN105916501A (zh) | 2013-12-06 | 2016-08-31 | 豪夫迈·罗氏有限公司 | 用于治疗局部晚期或转移性雌激素受体阳性乳腺癌的雌激素受体调节剂 |
| SG11201607334YA (en) | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Therapeutic combinations with estrogen receptor modulators |
| CA2941161A1 (en) | 2014-03-13 | 2015-09-17 | F.Hoffmann-La Roche Ag | Methods and compositions for modulating estrogen receptor mutants |
-
2015
- 2015-08-10 WO PCT/EP2015/068327 patent/WO2016023847A1/en not_active Ceased
- 2015-08-10 BR BR112016029604A patent/BR112016029604A2/pt not_active Application Discontinuation
- 2015-08-10 AU AU2015303297A patent/AU2015303297A1/en not_active Abandoned
- 2015-08-10 RU RU2017105840A patent/RU2017105840A/ru unknown
- 2015-08-10 KR KR1020177003624A patent/KR20170040251A/ko not_active Withdrawn
- 2015-08-10 SG SG11201700995WA patent/SG11201700995WA/en unknown
- 2015-08-10 EP EP15756368.5A patent/EP3180316A1/en not_active Withdrawn
- 2015-08-10 MX MX2017001869A patent/MX2017001869A/es unknown
- 2015-08-10 JP JP2017507716A patent/JP2017524009A/ja active Pending
- 2015-08-10 AR ARP150102564A patent/AR101487A1/es unknown
- 2015-08-10 CA CA2949329A patent/CA2949329A1/en active Pending
- 2015-08-10 CN CN201580041179.8A patent/CN106660969A/zh active Pending
- 2015-08-10 US US14/821,931 patent/US9783503B2/en not_active Expired - Fee Related
-
2016
- 2016-11-18 ZA ZA2016/08000A patent/ZA201608000B/en unknown
- 2016-11-23 IL IL249160A patent/IL249160A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201608000B (en) | 2017-09-27 |
| JP2017524009A (ja) | 2017-08-24 |
| AR101487A1 (es) | 2016-12-21 |
| KR20170040251A (ko) | 2017-04-12 |
| CA2949329A1 (en) | 2016-02-18 |
| EP3180316A1 (en) | 2017-06-21 |
| AU2015303297A1 (en) | 2016-12-01 |
| BR112016029604A2 (pt) | 2017-08-22 |
| RU2017105840A (ru) | 2018-09-13 |
| US9783503B2 (en) | 2017-10-10 |
| IL249160A0 (en) | 2017-01-31 |
| WO2016023847A1 (en) | 2016-02-18 |
| CN106660969A (zh) | 2017-05-10 |
| SG11201700995WA (en) | 2017-03-30 |
| US20160039770A1 (en) | 2016-02-11 |
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