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MX2016016797A - Extraccion de solvente de microparticulas biodegradables. - Google Patents

Extraccion de solvente de microparticulas biodegradables.

Info

Publication number
MX2016016797A
MX2016016797A MX2016016797A MX2016016797A MX2016016797A MX 2016016797 A MX2016016797 A MX 2016016797A MX 2016016797 A MX2016016797 A MX 2016016797A MX 2016016797 A MX2016016797 A MX 2016016797A MX 2016016797 A MX2016016797 A MX 2016016797A
Authority
MX
Mexico
Prior art keywords
solvent concentration
microparticles
solvent
concentration
aqueous suspension
Prior art date
Application number
MX2016016797A
Other languages
English (en)
Inventor
Bryden Sebring Greg
Original Assignee
Antriabio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antriabio Inc filed Critical Antriabio Inc
Publication of MX2016016797A publication Critical patent/MX2016016797A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0415—Solvent extraction of solutions which are liquid in combination with membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0492—Applications, solvents used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/206—Hardening; drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

Las incorporaciones pueden incluir un método para reducir una concentración de solvente en una pluralidad de micropartículas. El método puede involucrar el poner en contacto una mezcla incluyendo la pluralidad de micropartículas y el solvente con agua para formar una suspensión acuosa. Una primera parte del solvente puede disolverse dentro del agua de la suspensión acuosa para reducir la concentración de solvente en la pluralidad de micropartículas desde una primera concentración de solvente en la mezcla a una segunda concentración de solvente en la suspensión acuosa. El método también puede incluir transferir la suspensión acuosa a una unidad de concentración que puede además reducir la concentración de solvente desde la segunda concentración de solvente a una tercera concentración de solvente. El método puede además incluir transferir el concentrado de micropartículas con la tercera concentración de solvente a la unidad de lavado para formar una amalgama de micropartículas lavadas con una cuarta concentración de solvente. El método puede además el incluir el secar la amalgama de micropartículas lavadas.
MX2016016797A 2014-07-07 2015-07-07 Extraccion de solvente de microparticulas biodegradables. MX2016016797A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/324,734 US9439864B2 (en) 2014-07-07 2014-07-07 Solvent extraction from biodegradable microparticles
PCT/US2015/039316 WO2016007468A1 (en) 2014-07-07 2015-07-07 Solvent extraction from biodegradable microparticles

Publications (1)

Publication Number Publication Date
MX2016016797A true MX2016016797A (es) 2017-06-30

Family

ID=55016222

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016016797A MX2016016797A (es) 2014-07-07 2015-07-07 Extraccion de solvente de microparticulas biodegradables.

Country Status (12)

Country Link
US (3) US9439864B2 (es)
EP (1) EP3166598A4 (es)
JP (1) JP6555725B2 (es)
KR (1) KR20170026625A (es)
CN (1) CN106535879B (es)
AU (1) AU2015288014C1 (es)
BR (1) BR112016028385A2 (es)
CA (1) CA2949995A1 (es)
MX (1) MX2016016797A (es)
RU (1) RU2696860C2 (es)
WO (1) WO2016007468A1 (es)
ZA (1) ZA201608093B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9439864B2 (en) 2014-07-07 2016-09-13 Antriabio, Inc. Solvent extraction from biodegradable microparticles
US10039801B2 (en) 2016-02-16 2018-08-07 Strongbridge Ireland Limited Pharmaceutical compositions of water soluble peptides with poor solubility in isotonic conditions and methods for their use
CN112915585B (zh) * 2020-07-29 2022-03-22 珠海市标定检测技术有限公司 一种具有自动萃取和取液功能的萃取装置及萃取方法
CN112326399B (zh) * 2020-10-21 2022-09-09 江苏金信检测技术服务有限公司 一种快速萃取池除水方法
KR102259589B1 (ko) * 2020-11-30 2021-06-02 (주)인벤티지랩 미소구체 제조 시스템 및 미소구체 제조 방법
KR102283250B1 (ko) 2020-12-24 2021-07-29 (주)인벤티지랩 용매 제거 장치 및 이를 이용한 미소구체 제조 방법
KR102403990B1 (ko) 2021-12-22 2022-05-31 (주)인벤티지랩 용매 제거 장치 및 이를 이용한 미소구체 제조 방법
EP4545174A1 (en) * 2021-12-22 2025-04-30 Inventage Lab Inc. Solvent removing apparatus and method of manufacturing microsphere using the same
KR102686942B1 (ko) * 2022-01-26 2024-07-24 (주)인벤티지랩 용매 제거 장치 및 이를 이용한 미소구체 제조 방법
CN116212441B (zh) * 2022-12-26 2025-10-03 广东逸舒制药股份有限公司 一种中药热回流提取设备以及提取过程控制方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
AU2810189A (en) 1987-10-30 1989-05-23 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
US5478564A (en) 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
EP0724432B1 (en) * 1993-10-22 2002-09-18 Genentech, Inc. Methods and compositions for microencapsulation of antigens for use as vaccines
EP2275089A1 (en) 1993-11-19 2011-01-19 Alkermes Controlled Therapeutics, Inc. Preparation of biodegradable microparticles containing a biologically active agent
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US6123848A (en) 1997-02-14 2000-09-26 Warner-Jenkinson Company, Inc. Ultrafiltration method for purifying water-insoluble aluminum hydrates
EP1030652B1 (en) * 1997-11-14 2012-04-25 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
US6270802B1 (en) * 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6194006B1 (en) * 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US6291013B1 (en) * 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
US6471995B1 (en) * 2000-09-27 2002-10-29 Alkermes Controlled Therapeutics, Inc. Ii Apparatus and method for preparing microparticles using liquid-liquid extraction
DE60132094T3 (de) * 2001-10-26 2012-02-02 Octoplus Polyactive Sciences B.V. Verfahren zur Herstellung von gereinigten Partikeln
WO2004024056A1 (ja) * 2002-09-11 2004-03-25 Tanabe Seiyaku Co., Ltd. マイクロスフェアの製法及び製造装置
US20070207211A1 (en) 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
CN102166192B (zh) 2003-04-10 2013-09-25 Pr药品有限公司 一种用于生产基于乳化的微观粒子的方法
CN1777440A (zh) 2003-04-11 2006-05-24 Pr药品有限公司 位点特异性蛋白质偶联物的制备方法
WO2005025543A2 (en) * 2003-09-08 2005-03-24 Alkermes Controlled Therapeutics, Inc. Polymer-based sustained release device and method for preparation
WO2008157540A1 (en) 2007-06-20 2008-12-24 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
AU2008277886B8 (en) * 2007-07-17 2013-08-01 F. Hoffmann-La Roche Ag Variable tangential flow filtration
US8703843B2 (en) * 2008-09-11 2014-04-22 Evonik Corporation Solvent extraction microencapsulation with tunable extraction rates
US9439864B2 (en) 2014-07-07 2016-09-13 Antriabio, Inc. Solvent extraction from biodegradable microparticles

Also Published As

Publication number Publication date
EP3166598A1 (en) 2017-05-17
RU2017103693A3 (es) 2019-03-15
CA2949995A1 (en) 2016-01-14
CN106535879A (zh) 2017-03-22
US10137089B2 (en) 2018-11-27
US9439864B2 (en) 2016-09-13
CN106535879B (zh) 2019-12-13
KR20170026625A (ko) 2017-03-08
US20160000713A1 (en) 2016-01-07
RU2696860C2 (ru) 2019-08-07
RU2017103693A (ru) 2018-08-07
ZA201608093B (en) 2019-05-29
JP2017523128A (ja) 2017-08-17
WO2016007468A1 (en) 2016-01-14
AU2015288014B2 (en) 2020-04-16
US20160128942A1 (en) 2016-05-12
JP6555725B2 (ja) 2019-08-07
EP3166598A4 (en) 2018-03-07
US9532953B2 (en) 2017-01-03
AU2015288014C1 (en) 2020-07-16
BR112016028385A2 (pt) 2017-08-22
AU2015288014A1 (en) 2016-11-17
US20170071860A1 (en) 2017-03-16

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