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MX2016015218A - Antibioticos macrociclicos de amplio espectro. - Google Patents

Antibioticos macrociclicos de amplio espectro.

Info

Publication number
MX2016015218A
MX2016015218A MX2016015218A MX2016015218A MX2016015218A MX 2016015218 A MX2016015218 A MX 2016015218A MX 2016015218 A MX2016015218 A MX 2016015218A MX 2016015218 A MX2016015218 A MX 2016015218A MX 2016015218 A MX2016015218 A MX 2016015218A
Authority
MX
Mexico
Prior art keywords
broad spectrum
compounds
spectrum antibiotics
macrocyclic
macrocyclic broad
Prior art date
Application number
MX2016015218A
Other languages
English (en)
Inventor
Bradley Schwarz Jacob
Ly Cuong
Curran Roberts Tucker
Andrew Smith Peter
I Higuchi Robert
Paraselli Prasuna
Bergeron Philippe
F T Koehler Michael
Hu Huiyong
Crawford James
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2016015218A publication Critical patent/MX2016015218A/es

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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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    • A61K31/425—Thiazoles
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    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En el presente documento se proporcionan compuestos antibacterianos, en que los compuestos en algunas realizaciones tienen bioactividad de amplio espectro. En diversas realizaciones, los compuestos actúan mediante la inhibición de la peptidasa señal de tipo 1 bacteriana (SpsB), una proteína esencial en bacterias. También se proporcionan composiciones farmacéuticas y métodos para el tratamiento usando los compuestos descritos en el presente documento.
MX2016015218A 2014-05-20 2015-05-19 Antibioticos macrociclicos de amplio espectro. MX2016015218A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462000980P 2014-05-20 2014-05-20
US201562142404P 2015-04-02 2015-04-02
PCT/US2015/031631 WO2015179441A2 (en) 2014-05-20 2015-05-19 Macrocyclic broad spectrum antibiotics

Publications (1)

Publication Number Publication Date
MX2016015218A true MX2016015218A (es) 2017-07-04

Family

ID=54554959

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016015218A MX2016015218A (es) 2014-05-20 2015-05-19 Antibioticos macrociclicos de amplio espectro.

Country Status (10)

Country Link
US (1) US10392422B2 (es)
EP (1) EP3145944B1 (es)
JP (2) JP6823588B2 (es)
KR (1) KR20170027721A (es)
CN (1) CN106661084B (es)
BR (1) BR112016027232A2 (es)
CA (1) CA2949681A1 (es)
MX (1) MX2016015218A (es)
RU (1) RU2016146581A (es)
WO (1) WO2015179441A2 (es)

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MX2019003425A (es) 2016-09-28 2019-08-16 Blade Therapeutics Inc Moduladores de calpainas y usos terapeuticos de los mismos.
EP3330260A1 (en) * 2016-12-01 2018-06-06 Enantia, S.L. Process for the preparation of an intermediate for the synthesis of i.a. carfilzomib
CN110520413B (zh) * 2017-02-15 2023-02-17 阿奇克斯制药公司 大环广谱抗生素
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CN106966947B (zh) * 2017-03-30 2019-09-03 河北医科大学 一种维格列汀的制备方法
KR20250086794A (ko) * 2017-12-15 2025-06-13 메르크 파텐트 게엠베하 유기 전계 발광 디바이스용 치환된 방향족 아민
CN108806787B (zh) * 2018-07-06 2022-04-05 上海长海医院 面向临床手术的医用耗材智能监控系统
CN109355404B (zh) * 2018-08-30 2022-03-29 华南理工大学 基于聚合酶螺旋反应恒温检测单增李斯特菌的引物、试剂盒及检测方法
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