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MX2016015126A - Composiciones de angiotensinogeno (agt) arni y metodos de uso de las mismas. - Google Patents

Composiciones de angiotensinogeno (agt) arni y metodos de uso de las mismas.

Info

Publication number
MX2016015126A
MX2016015126A MX2016015126A MX2016015126A MX2016015126A MX 2016015126 A MX2016015126 A MX 2016015126A MX 2016015126 A MX2016015126 A MX 2016015126A MX 2016015126 A MX2016015126 A MX 2016015126A MX 2016015126 A MX2016015126 A MX 2016015126A
Authority
MX
Mexico
Prior art keywords
agt
methods
angiotensinogen
irna compositions
rnai agents
Prior art date
Application number
MX2016015126A
Other languages
English (en)
Other versions
MX382901B (es
Inventor
Hinkle Gregory
Milstein Stuart
Bettencourt Brian
Maier Martin
Charisse Klaus
Foster Donald
Kuchimanchi Satyanarayana
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2016015126A publication Critical patent/MX2016015126A/es
Publication of MX382901B publication Critical patent/MX382901B/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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Abstract

La presente invención se refiere a agentes de ARNi, por ejemplo, agente de ARNi de doble hebra que fijan como objetivo el gen de angiotensinógeno (AGT), y método para usar tales agentes de ARNi para inhibir la expresión de AGT y métodos para tratar sujetos que tienen un trastorno asociado con AGT, por ejemplo, hipertensión.
MX2016015126A 2014-05-22 2015-05-22 Composiciones de angiotensinogeno (agt) arni y métodos de uso de las mismas. MX382901B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462001731P 2014-05-22 2014-05-22
US201462047978P 2014-09-09 2014-09-09
PCT/US2015/032099 WO2015179724A1 (en) 2014-05-22 2015-05-22 Angiotensinogen (agt) irna compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2016015126A true MX2016015126A (es) 2017-02-23
MX382901B MX382901B (es) 2025-03-13

Family

ID=53298624

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016015126A MX382901B (es) 2014-05-22 2015-05-22 Composiciones de angiotensinogeno (agt) arni y métodos de uso de las mismas.
MX2021006053A MX2021006053A (es) 2014-05-22 2016-11-17 Composiciones de angiotensinogeno (agt) arni y metodos de uso de las mismas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021006053A MX2021006053A (es) 2014-05-22 2016-11-17 Composiciones de angiotensinogeno (agt) arni y metodos de uso de las mismas.

Country Status (14)

Country Link
US (5) US10238749B2 (es)
EP (2) EP3739048A1 (es)
JP (4) JP6811094B2 (es)
KR (3) KR102849498B1 (es)
CN (3) CN106574268B (es)
AU (2) AU2015264038B2 (es)
BR (2) BR112016026950B1 (es)
CA (2) CA2948381C (es)
EA (1) EA201692370A1 (es)
IL (2) IL248816B (es)
MX (2) MX382901B (es)
SG (2) SG10202104570TA (es)
WO (1) WO2015179724A1 (es)
ZA (2) ZA201607666B (es)

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IL316808A (en) 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
EP3276003B1 (en) 2015-03-27 2022-07-20 Bonac Corporation Single-chain nucleic acid molecule having delivery function and gene expression control ability
JP6892433B2 (ja) 2015-04-03 2021-06-23 ユニバーシティ・オブ・マサチューセッツＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ 十分に安定化された非対称ｓｉｒｎａ
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US10633653B2 (en) * 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
MY200263A (en) * 2015-10-08 2023-12-18 Ionis Pharmaceuticals Inc Compounds and methods for modulating angiotensinogen expression
HK1259060A1 (en) * 2015-12-29 2019-11-22 国立大学法人北海道大学 Single-stranded nucleic acid molecule inhibiting expression of prorenin gene or prorenin receptor gene, and use thereof
JP7749201B6 (ja) 2016-01-31 2025-10-21 ユニバーシティー オブ マサチューセッツ 分岐オリゴヌクレオチド
KR101916652B1 (ko) * 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
WO2018031933A2 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
US10844377B2 (en) 2017-06-23 2020-11-24 University Of Massachusetts Two-tailed self-delivering siRNA
TWI851574B (zh) * 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
KR20210093227A (ko) 2018-08-10 2021-07-27 유니버시티 오브 매사추세츠 Snp를 표적화하는 변형된 올리고뉴클레오티드
WO2020041769A1 (en) 2018-08-23 2020-02-27 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
WO2020150636A1 (en) 2019-01-18 2020-07-23 University Of Massachusetts Dynamic pharmacokinetic-modifying anchors
MX2022001710A (es) 2019-08-09 2022-05-10 Univ Massachusetts Oligonucleótidos modificados químicamente dirigidos a los snp.
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
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EP4136103A4 (en) 2020-04-17 2024-05-15 HB Biotech, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES
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