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MX2016014945A - 1- ((3s,4r) -4- (3-fluorofenil) -1- (2-metoxietil) pirrolidin-3-il) -3- (4-metil-3- (2-metilpirimidin-5-il) -1-fenil-1h-pirazol-5-il) urea como inhibidor de trka cinasa. - Google Patents

1- ((3s,4r) -4- (3-fluorofenil) -1- (2-metoxietil) pirrolidin-3-il) -3- (4-metil-3- (2-metilpirimidin-5-il) -1-fenil-1h-pirazol-5-il) urea como inhibidor de trka cinasa.

Info

Publication number
MX2016014945A
MX2016014945A MX2016014945A MX2016014945A MX2016014945A MX 2016014945 A MX2016014945 A MX 2016014945A MX 2016014945 A MX2016014945 A MX 2016014945A MX 2016014945 A MX2016014945 A MX 2016014945A MX 2016014945 A MX2016014945 A MX 2016014945A
Authority
MX
Mexico
Prior art keywords
diseases
trka kinase
kinase inhibitor
methylpyrimidin
pyrazol
Prior art date
Application number
MX2016014945A
Other languages
English (en)
Inventor
W Andrews Steven
Allen Shelley
Baer Brian
Crane Zackary
Liu Weidong
John WATSON Daniel
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of MX2016014945A publication Critical patent/MX2016014945A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Se proporciona el compuesto (1): (Ver Fórmula) o una sal farmacéuticamente aceptable del mismo, el cual es un inhibidor de la cinasa TrkA y es útil en el tratamiento de las enfermedades que puedan ser tratadas con un inhibidor de cinasa TrkA, tales como dolor, cáncer, inflamación y enfermedades inflamatorias, síndrome de Sjogren, endometriosis, neuropatía periférica diabética, prostatitis, síndrome de dolor pélvico, enfermedades relacionadas con un desequilibrio de la regulación de la remodelación ósea, y enfermedades resultantes de una señalización aberrante del factor de crecimiento de tejido conectivo.
MX2016014945A 2014-05-15 2015-05-14 1- ((3s,4r) -4- (3-fluorofenil) -1- (2-metoxietil) pirrolidin-3-il) -3- (4-metil-3- (2-metilpirimidin-5-il) -1-fenil-1h-pirazol-5-il) urea como inhibidor de trka cinasa. MX2016014945A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461993426P 2014-05-15 2014-05-15
PCT/US2015/030795 WO2015175788A1 (en) 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor

Publications (1)

Publication Number Publication Date
MX2016014945A true MX2016014945A (es) 2017-03-27

Family

ID=53276291

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016014945A MX2016014945A (es) 2014-05-15 2015-05-14 1- ((3s,4r) -4- (3-fluorofenil) -1- (2-metoxietil) pirrolidin-3-il) -3- (4-metil-3- (2-metilpirimidin-5-il) -1-fenil-1h-pirazol-5-il) urea como inhibidor de trka cinasa.
MX2019012600A MX2019012600A (es) 2014-05-15 2016-11-14 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)pirrolidin-3-il)-3-( 4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea como inhibidor de trka cinasa.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019012600A MX2019012600A (es) 2014-05-15 2016-11-14 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)pirrolidin-3-il)-3-( 4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea como inhibidor de trka cinasa.

Country Status (30)

Country Link
US (1) US10835533B2 (es)
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