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MX2016012769A - Anticuerpos de alta afinidad y agregacion estable basados en dominios variables de vl y derivado de vhh. - Google Patents

Anticuerpos de alta afinidad y agregacion estable basados en dominios variables de vl y derivado de vhh.

Info

Publication number
MX2016012769A
MX2016012769A MX2016012769A MX2016012769A MX2016012769A MX 2016012769 A MX2016012769 A MX 2016012769A MX 2016012769 A MX2016012769 A MX 2016012769A MX 2016012769 A MX2016012769 A MX 2016012769A MX 2016012769 A MX2016012769 A MX 2016012769A
Authority
MX
Mexico
Prior art keywords
vhh
derivative
variable domains
high affinity
antibodies based
Prior art date
Application number
MX2016012769A
Other languages
English (en)
Other versions
MX391476B (es
Inventor
Rudolfovich EVDOKIMOV Stanislav
Vladimirovich Soloviev Valeriy
Sergeevna Chernyh Yulia
Vladimirovna Goncharova Olga
Valerievich KORZHAVIN Dmitriy
Veniaminovna Chernovskaya Tatyana
Alexeevich IVANOV Roman
Valentinovich Morozov Dmitriy
Borisovich Ulitin Andre
Aleksandrovich Nemankin Timofey
Mikhailovna Ekimova Victoria
Vladimirovna Sofronova Ekaterina
Yurevich Ustyugov Yakov
Original Assignee
Biocad Cjsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocad Cjsc filed Critical Biocad Cjsc
Publication of MX2016012769A publication Critical patent/MX2016012769A/es
Publication of MX391476B publication Critical patent/MX391476B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39591—Stabilisation, fragmentation
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

Se proponen los anticuerpos monoclonales tipo IgG que comprenden dominios variables representados por una combinación del derivado de VHH con un dominio variable de la cadena ligera VL. Estos anticuerpos pueden comprender sustituciones de aminoácidos en las posiciones 44 y 45 (numeración de Kabat) o sus combinaciones. Los anticuerpos de la invención poseen afinidad aumentada y estabilidad de aglomeración mejorada.
MX2016012769A 2014-09-26 2015-03-23 Anticuerpos de alta afinidad y agregacion estable basados en dominios variables de vl y derivado de vhh. MX391476B (es)

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RU2014138740A RU2609627C2 (ru) 2014-09-26 2014-09-26 Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh
PCT/RU2015/000163 WO2016048188A1 (ru) 2014-09-26 2015-03-23 Высокоаффиные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh

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