MX2016011465A - Drimenol-sintasas y metodos para producir drimenol. - Google Patents
Drimenol-sintasas y metodos para producir drimenol.Info
- Publication number
- MX2016011465A MX2016011465A MX2016011465A MX2016011465A MX2016011465A MX 2016011465 A MX2016011465 A MX 2016011465A MX 2016011465 A MX2016011465 A MX 2016011465A MX 2016011465 A MX2016011465 A MX 2016011465A MX 2016011465 A MX2016011465 A MX 2016011465A
- Authority
- MX
- Mexico
- Prior art keywords
- drimenol
- polypeptides
- producing
- synthases
- useful
- Prior art date
Links
- HMWSKUKBAWWOJL-KCQAQPDRSA-N drimenol Chemical compound CC1(C)CCC[C@]2(C)[C@@H](CO)C(C)=CC[C@H]21 HMWSKUKBAWWOJL-KCQAQPDRSA-N 0.000 title abstract 5
- HMWSKUKBAWWOJL-UHFFFAOYSA-N Drimenol Natural products CC1(C)CCCC2(C)C(CO)C(C)=CCC21 HMWSKUKBAWWOJL-UHFFFAOYSA-N 0.000 title abstract 3
- HMWSKUKBAWWOJL-YDHLFZDLSA-N drimentol Natural products OC[C@H]1C(C)=CC[C@H]2C(C)(C)CCC[C@@]12C HMWSKUKBAWWOJL-YDHLFZDLSA-N 0.000 title abstract 3
- 101000924190 Aspergillus calidoustus Drimenol cyclase drtB Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- VWFJDQUYCIWHTN-YFVJMOTDSA-N 2-trans,6-trans-farnesyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-YFVJMOTDSA-N 0.000 abstract 1
- VWFJDQUYCIWHTN-FBXUGWQNSA-N Farnesyl diphosphate Natural products CC(C)=CCC\C(C)=C/CC\C(C)=C/COP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-FBXUGWQNSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a un método para producir drimenol y/o derivados de drimenol mediante la puesta en contacto de al menos un polipéptido con farnesil-difosfato. El método se puede realizar in vitro o in vivo. La presente invención también proporciona secuencias de aminoácidos de polipéptidos útiles en el método de la invención y ácido nucleico que codifica para los polipéptidos de la invención. El método proporciona además organismos o células hospedadoras genéticamente modificadas para expresar los polipéptidos de la invención útiles para producir trimenol y/o derivados de drimenol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014076850 | 2014-05-21 | ||
| PCT/EP2015/059987 WO2015176959A1 (en) | 2014-05-21 | 2015-05-06 | Drimenol synthases and method for producing drimenol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016011465A true MX2016011465A (es) | 2016-11-16 |
Family
ID=53365971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016011465A MX2016011465A (es) | 2014-05-21 | 2015-05-06 | Drimenol-sintasas y metodos para producir drimenol. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10351880B2 (es) |
| EP (1) | EP3140409B1 (es) |
| JP (1) | JP6562950B2 (es) |
| CN (1) | CN106459949A (es) |
| BR (1) | BR112016025898A2 (es) |
| MX (1) | MX2016011465A (es) |
| WO (1) | WO2015176959A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015169871A2 (en) * | 2014-05-06 | 2015-11-12 | Firmenich S.A. | Drimenol synthases ii |
| MX2018005218A (es) * | 2015-11-05 | 2018-08-01 | Firmenich & Cie | Drimenol sintasas iii. |
| JPWO2017221861A1 (ja) * | 2016-06-21 | 2019-04-11 | 日本電気株式会社 | はんだペーストおよびはんだ接合体 |
| CN110582568B (zh) * | 2017-05-03 | 2024-04-16 | 弗门尼舍有限公司 | 用于产生补身醇及其混合物的倍半萜合酶 |
| NL2019473B1 (en) * | 2017-09-01 | 2019-03-11 | Isobionics B V | Terpene Synthase producing patchoulol and elemol, and preferably also pogostol |
| US11345907B2 (en) * | 2018-05-29 | 2022-05-31 | Firmenich Sa | Method for producing albicanol compounds |
| EP3827089A1 (en) | 2018-10-15 | 2021-06-02 | Firmenich SA | Method for producing drimanyl acetate compounds |
| CN117844729B (zh) * | 2024-03-05 | 2024-06-04 | 北京大学深圳研究生院 | 一种重组菌株及其制备方法与应用、补身醇的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2768952A2 (en) * | 2011-10-19 | 2014-08-27 | Keygene N.V. | Methods for producing cinnamolide and/or drimendiol |
-
2015
- 2015-05-06 BR BR112016025898A patent/BR112016025898A2/pt not_active Application Discontinuation
- 2015-05-06 CN CN201580023218.1A patent/CN106459949A/zh active Pending
- 2015-05-06 WO PCT/EP2015/059987 patent/WO2015176959A1/en not_active Ceased
- 2015-05-06 MX MX2016011465A patent/MX2016011465A/es unknown
- 2015-05-06 EP EP15727564.5A patent/EP3140409B1/en active Active
- 2015-05-06 JP JP2016566719A patent/JP6562950B2/ja not_active Expired - Fee Related
- 2015-05-06 US US15/330,813 patent/US10351880B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016025898A2 (pt) | 2017-12-12 |
| CN106459949A (zh) | 2017-02-22 |
| JP2017518741A (ja) | 2017-07-13 |
| JP6562950B2 (ja) | 2019-08-21 |
| EP3140409B1 (en) | 2019-07-10 |
| US10351880B2 (en) | 2019-07-16 |
| EP3140409A1 (en) | 2017-03-15 |
| WO2015176959A1 (en) | 2015-11-26 |
| US20180208948A1 (en) | 2018-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2016011465A (es) | Drimenol-sintasas y metodos para producir drimenol. | |
| MY203884A (en) | Taurine supplemented cell culture medium and methods of use | |
| PH12014500348A1 (en) | Genes and proteins for alkanoyl-coa synthesis | |
| BR112017014031A2 (pt) | n-oligossacaril-transferase recombinante, mutante de n-oligossacaril-transferase recombinante, ácido nucleico, célula hospedeira, e, método para produção de um bioconjugado. | |
| EP4219744A3 (en) | Methods of preparing nucleic acids for sequencing | |
| MX351565B (es) | Colageno 7 y metodos relacionados. | |
| MX395280B (es) | Sintasa del acido cannabicromenico proveniente de cannabis sativa. | |
| SG10201909180SA (en) | Humanized anti-c1s antibodies and methods of use thereof | |
| IN2015DN00849A (es) | ||
| PH12016502024A1 (en) | Tonoplast proton/sugar antiporter proteins and the use thereof to increase the saccharose concentration in a saccharose storage organ of plants | |
| PH12017500309A1 (en) | Anti-vasa antibodies, and methods of production and use thereof | |
| MX389029B (es) | Metodos para valorar la pureza de una preparacion de celulas germinales mesenquimales | |
| NZ730124A (en) | A method of predicting risk of recurrence of cancer | |
| MX2016013955A (es) | Drimenol-sintasas y metodo de produccion de drimenol. | |
| MY198268A (en) | Omega-hydroxylase-related fusion polypeptides with improved properties | |
| MX2021011770A (es) | Produccion de manool. | |
| BR112015031236A2 (pt) | Produção de proteína em plantas | |
| IN2013MU02316A (es) | ||
| MX2018005218A (es) | Drimenol sintasas iii. | |
| MY194277A (en) | Omega-hydroxylase-related fusion polypeptide variants with improved properties | |
| MY193535A (en) | Cell culture methods | |
| MX2013013063A (es) | Plantas que tienen rasgos mejorados relacionados con el rendimiento y metodo para elaborar las mismas. | |
| WO2015117033A3 (en) | Methods of increasing protein production in mammalian cells | |
| MX380693B (es) | Produccion de manool. | |
| PH12014502227A1 (en) | Plants having one or more enhanced yield-related traits and method for making the same |