MX2016008023A - Composiciones y metodos para inhibir la inflamacion y las enfermedades utilizando un compuesto antimicrobiano con base en acido alginico. - Google Patents
Composiciones y metodos para inhibir la inflamacion y las enfermedades utilizando un compuesto antimicrobiano con base en acido alginico.Info
- Publication number
- MX2016008023A MX2016008023A MX2016008023A MX2016008023A MX2016008023A MX 2016008023 A MX2016008023 A MX 2016008023A MX 2016008023 A MX2016008023 A MX 2016008023A MX 2016008023 A MX2016008023 A MX 2016008023A MX 2016008023 A MX2016008023 A MX 2016008023A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- methods
- alginic acid
- antimicrobial compound
- diseases
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 206010061218 Inflammation Diseases 0.000 title abstract 2
- 229960001126 alginic acid Drugs 0.000 title abstract 2
- 235000010443 alginic acid Nutrition 0.000 title abstract 2
- 229920000615 alginic acid Polymers 0.000 title abstract 2
- 239000000783 alginic acid Substances 0.000 title abstract 2
- 150000004781 alginic acids Chemical class 0.000 title abstract 2
- 239000004599 antimicrobial Substances 0.000 title abstract 2
- 230000004054 inflammatory process Effects 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 2
- 208000019802 Sexually transmitted disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000003139 buffering effect Effects 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 230000002254 contraceptive effect Effects 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000000415 inactivating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/02—Contraceptive devices; Pessaries; Applicators therefor for use by males
- A61F6/04—Condoms, sheaths or the like, e.g. combined with devices protecting against contagion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/065—Condom-like devices worn by females
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente divulgación se refiere a composiciones y métodos para inhibir la inflamación y reducir el riesgo de propagación de enfermedades de transmisión sexual mediante el uso un compuesto antimicrobiano con base en ácido algínico. Tales composiciones proporcionan protección dual mediante (1) el ataque y la inactivación de virus y otros microbios y (2) el bloqueo de la respuesta del huésped que los virus activan para invadir las células huésped. Tales composiciones también pueden ser parte de un anticonceptivo de amortiguamiento de ácido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361918445P | 2013-12-19 | 2013-12-19 | |
| PCT/US2014/071664 WO2015095793A1 (en) | 2013-12-19 | 2014-12-19 | Compositions and methods for inhibiting inflammation and diseases using an alginic acid-based antimicrobial compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016008023A true MX2016008023A (es) | 2017-01-13 |
Family
ID=53403777
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016008023A MX2016008023A (es) | 2013-12-19 | 2014-12-19 | Composiciones y metodos para inhibir la inflamacion y las enfermedades utilizando un compuesto antimicrobiano con base en acido alginico. |
| MX2021001742A MX2021001742A (es) | 2013-12-19 | 2016-06-17 | Composiciones y metodos para inhibir la inflamacion y las enfermedades utilizando un compuesto antimicrobiano con base en acido alginico. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021001742A MX2021001742A (es) | 2013-12-19 | 2016-06-17 | Composiciones y metodos para inhibir la inflamacion y las enfermedades utilizando un compuesto antimicrobiano con base en acido alginico. |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11337989B2 (es) |
| EP (2) | EP3082826B1 (es) |
| JP (3) | JP2017501227A (es) |
| KR (1) | KR102407408B1 (es) |
| CN (2) | CN114452298A (es) |
| AU (2) | AU2014368971B2 (es) |
| BR (1) | BR112016014506B1 (es) |
| DK (1) | DK3082826T3 (es) |
| ES (1) | ES2790703T3 (es) |
| IL (1) | IL246146B2 (es) |
| MX (2) | MX2016008023A (es) |
| NZ (1) | NZ722215A (es) |
| RU (1) | RU2691950C1 (es) |
| WO (1) | WO2015095793A1 (es) |
| ZA (1) | ZA201604862B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ703203A (en) | 2012-06-13 | 2016-07-29 | Evofem Inc | Compositions and methods for enhancing the efficacy of contraceptive microbicides |
| CN114452298A (zh) | 2013-12-19 | 2022-05-10 | 伊沃菲姆股份有限公司 | 使用基于藻酸的抗微生物化合物抑制炎症和疾病的组合物和方法 |
| DE102017110168A1 (de) | 2016-05-25 | 2017-11-30 | Samsung Electronics Co., Ltd. | Elektronische Vorrichtung mit NFC-Antenne |
| WO2018049326A1 (en) * | 2016-09-12 | 2018-03-15 | Evofem Biosciences, Inc. | Combination gel for sexually transmitted infections |
| EP3522879A4 (en) * | 2016-10-04 | 2020-06-03 | Evofem, Inc. | Method of treatment and prevention of bacterial vaginosis |
| EP4422640A4 (en) * | 2021-10-28 | 2025-11-19 | Evofem Inc | FAST-DISSOLVING VAGINAL FILM WITH CONTRACEPTIVE ACTION AND PREVENTION OF SEXUALLY TRANSMITTED INFECTION |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213323B (it) | 1986-08-07 | 1989-12-20 | Crinos Industria Farmaco | Composizione per uso locale ad atti vita' spermicida virulicida ,disinfettante e/o battericida |
| US4999342A (en) | 1988-08-16 | 1991-03-12 | Ortho Pharmaceutical Corporation | Long lasting contraceptive suppository composition and methods of use |
| JP3202365B2 (ja) * | 1992-12-04 | 2001-08-27 | 株式会社紀文フードケミファ | オリゴマンヌロン酸を重合度によって分離する方法 |
| US5592949A (en) | 1994-06-29 | 1997-01-14 | Moench; Thomas R. | Device for acidic buffering and method for inactivation of pathogens |
| US5667492A (en) | 1994-10-07 | 1997-09-16 | Columbia Laboratories, Inc. | Use and composition of an anti-sexually transmitted diseases formulation |
| FR2728464B1 (fr) | 1994-12-22 | 1997-04-30 | Innothera Lab Sa | Forme galenique unitaire, son procede d'obtention et ses utilisations |
| US6093394A (en) | 1997-04-11 | 2000-07-25 | Gynelogix, Inc. | Vaginal lactobacillus medicant |
| WO2001038284A1 (en) | 1999-11-24 | 2001-05-31 | Cargill Dow Llc | Improved lactic acid processing; methods; arrangements; and, products |
| AU2001243431B2 (en) * | 2000-03-07 | 2006-05-25 | Rush University Medical Center | Compositions and methods for trapping and inactivating pathogenic microbes and spermatozoa |
| JP2009102407A (ja) * | 2001-03-08 | 2009-05-14 | Rohto Pharmaceut Co Ltd | Gリッチなアルギン酸含有組成物 |
| US20020177624A1 (en) | 2001-03-16 | 2002-11-28 | Calvin Hanna | Acetate-lactate buffering vaginal gel and for method of making same and treating bacterial vaginosis |
| ITMI20010913A1 (it) | 2001-05-04 | 2002-11-04 | Univ Pavia | Composizioni a rilascio controllato di acido lattico a livello vaginale |
| CA2449247A1 (en) * | 2001-06-11 | 2002-12-19 | Merck & Co., Inc. | A method for treating inflammatory diseases by administering a ppar-delta agonist |
| US20130150810A1 (en) | 2002-04-30 | 2013-06-13 | The Population Council, Inc. | Intravaginal ring for the delivery of unique combinations of antimicrobial compositions |
| JP4712380B2 (ja) | 2002-07-26 | 2011-06-29 | 三笠製薬株式会社 | 外用剤 |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| DK1635847T3 (da) | 2003-06-13 | 2019-10-28 | Idh Holding Aps | Behandling af symptomer forbundet med bakteriel vaginose |
| US20050272700A1 (en) | 2004-05-10 | 2005-12-08 | Servet Buyuktimkin | Topical treatment and prevention of human papilloma virus (HPV) infection |
| RU2257197C1 (ru) * | 2004-05-12 | 2005-07-27 | Дулькис Мария Дмитриевна | Вагинальные суппозитории, обладающие контрацептивным действием |
| UA93354C2 (ru) | 2004-07-09 | 2011-02-10 | Гилиад Сайенсиз, Инк. | Местный противовирусный препарат |
| US20100069323A1 (en) * | 2006-11-10 | 2010-03-18 | Rohto Pharmaceutical Co., Ltd. | Composition for application to skin or mucosa |
| US7659259B2 (en) * | 2006-12-21 | 2010-02-09 | Bausch & Lomb Incorporated | Method of treating inflammation of the eye |
| RU2459620C2 (ru) | 2007-03-30 | 2012-08-27 | Лаккуре Аб | Применение олигомеров молочной кислоты в лечении гинекологических расстройств |
| AU2008256689A1 (en) | 2007-05-24 | 2008-12-04 | New York Blood Center Inc. | Rapidly dispersible vaginal tablet that provides a bioadhesive gel |
| TW200927141A (en) | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
| WO2009127825A1 (en) | 2008-04-16 | 2009-10-22 | Cipla Limited | Topical combinations comprising an antimycotic agent and an antiviral agent |
| WO2009155118A1 (en) * | 2008-05-30 | 2009-12-23 | Reprotect, Inc. | Compositions and methods for inactivation of pathogens at genital tract surfaces |
| EP2130531A1 (en) | 2008-06-04 | 2009-12-09 | Rolf Kullgren AB | Vaginal suppository comprising lactic acid |
| EP2440560A1 (en) | 2009-06-10 | 2012-04-18 | Ultimorphix Technologies B.v. | The succinate of tenofovir disoproxil |
| CA2839790A1 (en) * | 2011-05-02 | 2012-11-08 | Aptalis Pharmatech, Inc. | Rapid dissolve tablet compositions for vaginal administration |
| CA2840571C (en) | 2011-06-28 | 2020-03-24 | Medicis Pharmaceutical Corporation | High dosage mucoadhesive metronidazole aqueous-based gel formulations and their use to treat bacterial vaginosis |
| NZ703203A (en) * | 2012-06-13 | 2016-07-29 | Evofem Inc | Compositions and methods for enhancing the efficacy of contraceptive microbicides |
| WO2015027071A1 (en) | 2013-08-21 | 2015-02-26 | Georgia Regents Research Institute, Inc. | Gpr81 agonists and methods thereof for promoting production of secretory iga |
| CN114452298A (zh) | 2013-12-19 | 2022-05-10 | 伊沃菲姆股份有限公司 | 使用基于藻酸的抗微生物化合物抑制炎症和疾病的组合物和方法 |
| AU2015201042A1 (en) | 2014-02-28 | 2015-09-17 | Macfarlane Burnet Institute For Medical Research And Public Health Pty Ltd | Therapeutic Method |
-
2014
- 2014-12-19 CN CN202210078304.4A patent/CN114452298A/zh active Pending
- 2014-12-19 US US15/106,755 patent/US11337989B2/en active Active
- 2014-12-19 IL IL246146A patent/IL246146B2/en unknown
- 2014-12-19 MX MX2016008023A patent/MX2016008023A/es unknown
- 2014-12-19 DK DK14871611.1T patent/DK3082826T3/da active
- 2014-12-19 BR BR112016014506-2A patent/BR112016014506B1/pt active IP Right Grant
- 2014-12-19 ES ES14871611T patent/ES2790703T3/es active Active
- 2014-12-19 NZ NZ722215A patent/NZ722215A/en unknown
- 2014-12-19 EP EP14871611.1A patent/EP3082826B1/en active Active
- 2014-12-19 AU AU2014368971A patent/AU2014368971B2/en active Active
- 2014-12-19 CN CN201480075975.9A patent/CN106029078A/zh active Pending
- 2014-12-19 KR KR1020167019494A patent/KR102407408B1/ko active Active
- 2014-12-19 EP EP20161479.9A patent/EP3735966A1/en not_active Withdrawn
- 2014-12-19 JP JP2016560871A patent/JP2017501227A/ja active Pending
- 2014-12-19 WO PCT/US2014/071664 patent/WO2015095793A1/en not_active Ceased
- 2014-12-19 RU RU2016129069A patent/RU2691950C1/ru active
-
2016
- 2016-06-17 MX MX2021001742A patent/MX2021001742A/es unknown
- 2016-07-14 ZA ZA2016/04862A patent/ZA201604862B/en unknown
-
2020
- 2020-03-31 JP JP2020063444A patent/JP2020125298A/ja active Pending
- 2020-04-29 AU AU2020202835A patent/AU2020202835B2/en active Active
-
2022
- 2022-02-07 JP JP2022017393A patent/JP2022070924A/ja active Pending
- 2022-04-19 US US17/724,378 patent/US20220241301A1/en not_active Abandoned
-
2024
- 2024-01-08 US US18/407,371 patent/US20240299426A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN106029078A (zh) | 2016-10-12 |
| AU2014368971B2 (en) | 2020-02-06 |
| JP2020125298A (ja) | 2020-08-20 |
| US20160354394A1 (en) | 2016-12-08 |
| RU2691950C1 (ru) | 2019-06-19 |
| CN114452298A (zh) | 2022-05-10 |
| AU2014368971A1 (en) | 2016-07-28 |
| EP3082826A1 (en) | 2016-10-26 |
| KR102407408B1 (ko) | 2022-06-10 |
| EP3735966A1 (en) | 2020-11-11 |
| NZ722215A (en) | 2019-02-22 |
| KR20160103036A (ko) | 2016-08-31 |
| BR112016014506A2 (pt) | 2017-10-31 |
| IL246146A0 (en) | 2016-07-31 |
| US20220241301A1 (en) | 2022-08-04 |
| AU2020202835A1 (en) | 2020-05-21 |
| IL246146B2 (en) | 2024-03-01 |
| ZA201604862B (en) | 2017-08-30 |
| JP2017501227A (ja) | 2017-01-12 |
| ES2790703T3 (es) | 2020-10-28 |
| AU2020202835B2 (en) | 2021-12-02 |
| EP3082826B1 (en) | 2020-03-11 |
| DK3082826T3 (da) | 2020-05-04 |
| IL246146B1 (en) | 2023-11-01 |
| WO2015095793A1 (en) | 2015-06-25 |
| JP2022070924A (ja) | 2022-05-13 |
| BR112016014506B1 (pt) | 2022-06-28 |
| US20240299426A1 (en) | 2024-09-12 |
| US11337989B2 (en) | 2022-05-24 |
| RU2016129069A (ru) | 2018-01-23 |
| EP3082826A4 (en) | 2017-08-23 |
| MX2021001742A (es) | 2021-04-19 |
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