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MX2016007985A - Compuestos de fluorofenilpirazol. - Google Patents

Compuestos de fluorofenilpirazol.

Info

Publication number
MX2016007985A
MX2016007985A MX2016007985A MX2016007985A MX2016007985A MX 2016007985 A MX2016007985 A MX 2016007985A MX 2016007985 A MX2016007985 A MX 2016007985A MX 2016007985 A MX2016007985 A MX 2016007985A MX 2016007985 A MX2016007985 A MX 2016007985A
Authority
MX
Mexico
Prior art keywords
fluorophenyl
pyrazol compounds
pyrazol
compounds
group
Prior art date
Application number
MX2016007985A
Other languages
English (en)
Inventor
Kun-Chin Liu Kevin
Wu Liang
Xie Yinong
Zhou Guoqiang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2016007985A publication Critical patent/MX2016007985A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

(ver Fórmula) La presente invención proporciona un compuesto de la fórmula: en donde X se selecciona del grupo que consiste en, R se selecciona del grupo que consiste en H y CH3; R1 se selecciona del grupo que consiste en H, CH3, F, CI, OCH3, C(O)OH, C(O)NH2 o una de sus sales farmacéuticamente aceptables.
MX2016007985A 2013-12-19 2014-12-11 Compuestos de fluorofenilpirazol. MX2016007985A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2013/089987 WO2015089800A1 (en) 2013-12-19 2013-12-19 Fluorophenyl pyrazol compounds
PCT/US2014/069785 WO2015094913A1 (en) 2013-12-19 2014-12-11 Fluorophenyl pyrazol compounds

Publications (1)

Publication Number Publication Date
MX2016007985A true MX2016007985A (es) 2016-09-09

Family

ID=52355187

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016007985A MX2016007985A (es) 2013-12-19 2014-12-11 Compuestos de fluorofenilpirazol.

Country Status (23)

Country Link
US (1) US9499490B2 (es)
EP (1) EP3083605B1 (es)
JP (1) JP6190067B2 (es)
KR (1) KR101827660B1 (es)
CN (1) CN105814039B (es)
AU (1) AU2014366436B2 (es)
BR (1) BR112016011778A8 (es)
CA (1) CA2929563C (es)
DK (1) DK3083605T3 (es)
EA (1) EA029058B1 (es)
ES (1) ES2664418T3 (es)
HR (1) HRP20180618T1 (es)
HU (1) HUE039102T2 (es)
LT (1) LT3083605T (es)
MX (1) MX2016007985A (es)
NO (1) NO3083605T3 (es)
PL (1) PL3083605T3 (es)
PT (1) PT3083605T (es)
RS (1) RS57071B1 (es)
SA (1) SA516371323B1 (es)
SI (1) SI3083605T1 (es)
TR (1) TR201802981T4 (es)
WO (2) WO2015089800A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3336B1 (ar) 2014-10-07 2019-03-13 Lilly Co Eli مركبات أمينو بيريديلوكسي بيرازول
WO2016066664A1 (en) * 2014-10-31 2016-05-06 F. Hoffmann-La Roche Ag New pyridinyloxy- and phenyloxy-pyrazolyl compounds
WO2016131198A1 (en) 2015-02-18 2016-08-25 Eli Lilly And Company Pyrazole compounds
WO2016201662A1 (en) * 2015-06-18 2016-12-22 Eli Lilly And Company Fluoropyridyl pyrazol compounds
CN109096194B (zh) * 2018-10-09 2022-02-08 湖南师范大学 一种双胍衍生物、药物组合物、制备方法和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024796A1 (en) * 1999-10-01 2001-04-12 Smithkline Beecham Corporation 1,2,4-triazole derivatives, composition, process of making and methods of use
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
US20040116495A1 (en) * 2001-03-29 2004-06-17 Marino Jr. Joseph P. Compounds and methods
EP1434772A4 (en) * 2001-10-12 2005-05-04 Smithkline Beecham Corp CONNECTIONS AND METHODS
WO2003051906A2 (en) * 2001-12-14 2003-06-26 Smithkline Beecham Corporation Compounds and methods
JP4498133B2 (ja) 2002-07-02 2010-07-07 シェーリング コーポレイション 新規神経ペプチドｙｙ５レセプターアンタゴニスト
US7253204B2 (en) 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
DE102004049078A1 (de) * 2004-10-08 2006-04-13 Merck Patent Gmbh Phenylpyrazole
WO2010065879A2 (en) * 2008-12-04 2010-06-10 Zafgen Corporation Methods of treating an overweight or obese subject
TW201245155A (en) 2010-09-01 2012-11-16 Du Pont Fungicidal pyrazoles
WO2012090219A2 (en) 2010-12-31 2012-07-05 Jubilant Biosys Ltd. Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors
US9062028B2 (en) * 2011-04-28 2015-06-23 Bristol-Myers Squibb Company Bicyclic nitrogen containing heteroaryl TGR5 receptor modulators
JO3336B1 (ar) 2014-10-07 2019-03-13 Lilly Co Eli مركبات أمينو بيريديلوكسي بيرازول

Also Published As

Publication number Publication date
BR112016011778A8 (pt) 2018-01-30
WO2015094913A1 (en) 2015-06-25
AU2014366436A1 (en) 2016-05-19
KR101827660B1 (ko) 2018-02-08
CA2929563A1 (en) 2015-06-25
US20160289195A1 (en) 2016-10-06
SI3083605T1 (en) 2018-04-30
US9499490B2 (en) 2016-11-22
HRP20180618T1 (hr) 2018-07-13
NO3083605T3 (es) 2018-07-21
CN105814039B (zh) 2018-07-17
SA516371323B1 (ar) 2018-04-24
TR201802981T4 (tr) 2018-03-21
EP3083605A1 (en) 2016-10-26
AU2014366436B2 (en) 2017-08-24
LT3083605T (lt) 2018-04-10
PT3083605T (pt) 2018-03-01
CA2929563C (en) 2018-05-15
KR20160075827A (ko) 2016-06-29
BR112016011778A2 (pt) 2017-08-08
EP3083605B1 (en) 2018-02-21
JP6190067B2 (ja) 2017-08-30
EA201690924A1 (ru) 2016-09-30
HUE039102T2 (hu) 2018-12-28
WO2015089800A1 (en) 2015-06-25
ES2664418T3 (es) 2018-04-19
CN105814039A (zh) 2016-07-27
PL3083605T3 (pl) 2018-07-31
RS57071B1 (sr) 2018-06-29
JP2016540801A (ja) 2016-12-28
EA029058B1 (ru) 2018-02-28
DK3083605T3 (en) 2018-03-12

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