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MX2016007346A - Derivados de dihidropiridinona y dihidropiridazinona utiles como inhibidores de bromodominio. - Google Patents

Derivados de dihidropiridinona y dihidropiridazinona utiles como inhibidores de bromodominio.

Info

Publication number
MX2016007346A
MX2016007346A MX2016007346A MX2016007346A MX2016007346A MX 2016007346 A MX2016007346 A MX 2016007346A MX 2016007346 A MX2016007346 A MX 2016007346A MX 2016007346 A MX2016007346 A MX 2016007346A MX 2016007346 A MX2016007346 A MX 2016007346A
Authority
MX
Mexico
Prior art keywords
dihydropyridinone
derivatives useful
bromodomain inhibitors
dihydropyridazinone derivatives
dihydropyridazinone
Prior art date
Application number
MX2016007346A
Other languages
English (en)
Inventor
Bogdan Andrew
M Kati Warren
H Park Chang
Wang Le
F Macdaniel Keith
S Sheppard Georg
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2016007346A publication Critical patent/MX2016007346A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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Abstract

La presente invención, proporciona compuestos de la fórmula (I) (ver Fórmula) en donde Y1, Y2, R1, R2, R3, A1, A2, A3, y A4, tienen cualquiera de los valores definidos en la especificación, y las sales farmacéuticamente aceptables de los mismos, que son útiles como agentes para el tratamiento de enfermedades y condiciones, incluyendo enfermedades inflamatorias, cáncer y SIDA. También se proporcionan las composiciones farmacéuticas comprendidas de uno o más compuestos de la fórmula (I).
MX2016007346A 2013-12-09 2014-12-09 Derivados de dihidropiridinona y dihidropiridazinona utiles como inhibidores de bromodominio. MX2016007346A (es)

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PCT/US2014/069350 WO2015089075A1 (en) 2013-12-09 2014-12-09 Dihydropyridinone and dihydropyridazinone derivatives useful as bromodomain inhibitors

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EP3089970A1 (en) 2016-11-09
CA2932030A1 (en) 2015-06-18
US10085985B2 (en) 2018-10-02
US20150158873A1 (en) 2015-06-11
US20190008866A1 (en) 2019-01-10
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