MX2016006299A - Procesos para la preparación de compuestos de pirimidinilciclopentano. - Google Patents
Procesos para la preparación de compuestos de pirimidinilciclopentano.Info
- Publication number
- MX2016006299A MX2016006299A MX2016006299A MX2016006299A MX2016006299A MX 2016006299 A MX2016006299 A MX 2016006299A MX 2016006299 A MX2016006299 A MX 2016006299A MX 2016006299 A MX2016006299 A MX 2016006299A MX 2016006299 A MX2016006299 A MX 2016006299A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- flexible substrate
- wearable
- useful
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- KHXLVDUXFUNEQQ-UHFFFAOYSA-N 2-cyclopentylpyrimidine Chemical class C1CCCC1C1=NC=CC=N1 KHXLVDUXFUNEQQ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000758 substrate Substances 0.000 abstract 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención se relaciona con un proceso para la preparación de un compuesto de fórmula (I), donde R1 es como se define en la presente, que es útil como intermediario en la preparación de los compuestos farmacéuticos activos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13193030 | 2013-11-15 | ||
| PCT/US2014/065567 WO2015073739A1 (en) | 2013-11-15 | 2014-11-13 | Processes for the preparation of pyrimidinylcyclopentane compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016006299A true MX2016006299A (es) | 2017-02-22 |
| MX367620B MX367620B (es) | 2019-08-28 |
Family
ID=49582648
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009462A MX385726B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| MX2019006959A MX374852B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparacion de compuestos de pirimidinilciclopentano |
| MX2016006299A MX367620B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009462A MX385726B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| MX2019006959A MX374852B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparacion de compuestos de pirimidinilciclopentano |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9862689B2 (es) |
| EP (3) | EP4282973A3 (es) |
| JP (4) | JP6374503B2 (es) |
| KR (2) | KR102698200B1 (es) |
| CN (3) | CN112898210B (es) |
| AR (1) | AR098427A1 (es) |
| AU (5) | AU2014348570B2 (es) |
| CA (2) | CA2930870C (es) |
| ES (2) | ES2957314T3 (es) |
| HR (2) | HRP20231100T1 (es) |
| HU (1) | HUE063095T2 (es) |
| IL (3) | IL245636B (es) |
| MX (3) | MX385726B (es) |
| MY (2) | MY191759A (es) |
| NZ (1) | NZ720805A (es) |
| PL (2) | PL3068770T3 (es) |
| RU (1) | RU2702355C1 (es) |
| SG (1) | SG10201901578UA (es) |
| SI (1) | SI3068770T1 (es) |
| WO (1) | WO2015073739A1 (es) |
| ZA (2) | ZA201603434B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX385726B (es) * | 2013-11-15 | 2025-03-18 | Hoffmann La Roche | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| BR112017005931B1 (pt) | 2014-09-26 | 2024-04-30 | F. Hoffmann-La Roche Ag | Processos para preparar um composto de ciclopentil[d]pirimidin-4-il) piperazina e composto de ciclopentil[d]pirimidin-4-il)piperazina |
| EP4613333A3 (en) | 2016-08-10 | 2025-10-29 | F. Hoffmann-La Roche AG | Pharmaceutical compositions comprising akt protein kinase inhibitors |
| GB201802383D0 (en) * | 2018-02-14 | 2018-03-28 | Givaudan Sa | Process |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6545165B1 (en) | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| EP1893595B1 (en) * | 2005-05-24 | 2008-09-03 | F. Hoffmann-Roche AG | Preparation of (s)-4-fluoromethyl-dihydro-furan-2-one |
| CN101198594A (zh) * | 2005-06-22 | 2008-06-11 | 尼科梅德有限责任公司 | 用于制备生产三环苯并咪唑类的中间体的方法 |
| ES2372955T3 (es) * | 2006-07-06 | 2012-01-30 | Array Biopharma, Inc. | Ciclopenta[d]pirimidinas como inhibidores de la proteína cinasa akt. |
| UA95641C2 (xx) | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| WO2009089459A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| CA2711692A1 (en) * | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
| AR070176A1 (es) * | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
| WO2010025238A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| CN102186972B (zh) | 2008-08-29 | 2014-08-20 | 科德克希思公司 | 用于立体选择性生产(4s)-3-[(5s)-5-(4-氟苯基)-5-羟基戊酰基]-4-苯基-1，3-噁唑烷-2-酮的酮还原酶多肽 |
| US20110054174A1 (en) * | 2009-08-28 | 2011-03-03 | Stephan Bachmann | Process for the preparation of a glucokinase activator compound |
| KR20130058672A (ko) * | 2010-04-16 | 2013-06-04 | 제넨테크, 인크. | ＰＩ3Ｋ/ＡＫＴ 키나제 경로 억제제 효능에 대한 예측 바이오마커로서의 ＦＯＸＯ３ａ |
| RS56759B2 (sr) * | 2011-04-01 | 2024-10-31 | Genentech Inc | Kombinacija akt inhibitor jedinjenja i abiraterona za upotrebu pri terapeutskim tretiranjima |
| SI2861582T1 (sl) * | 2012-05-17 | 2016-09-30 | Array Biopharma, Inc. | Postopek za izdelavo hidroksiliranih ciklopentilpirimidinskih spojin |
| EP2850200A1 (en) * | 2012-05-17 | 2015-03-25 | Genentech, Inc. | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
| HUE051254T2 (hu) * | 2012-05-17 | 2021-03-01 | Genentech Inc | Egy AKT-gátló pirimidin-ciklopentán vegyület amorf formája, annak kompozíciói és eljárásai |
| MX350443B (es) * | 2012-05-17 | 2017-09-06 | Genentech Inc | Proceso para hacer compuestos de aminoácidos. |
| CA2873653A1 (en) | 2012-05-17 | 2013-11-21 | Array Biopharma Inc. | Process for making hydroxylated cyclopentylpyrimidine compounds |
| MX385726B (es) | 2013-11-15 | 2025-03-18 | Hoffmann La Roche | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| BR112017005931B1 (pt) | 2014-09-26 | 2024-04-30 | F. Hoffmann-La Roche Ag | Processos para preparar um composto de ciclopentil[d]pirimidin-4-il) piperazina e composto de ciclopentil[d]pirimidin-4-il)piperazina |
-
2014
- 2014-11-13 MX MX2020009462A patent/MX385726B/es unknown
- 2014-11-13 EP EP23182382.4A patent/EP4282973A3/en active Pending
- 2014-11-13 US US15/036,741 patent/US9862689B2/en active Active
- 2014-11-13 MX MX2019006959A patent/MX374852B/es active IP Right Grant
- 2014-11-13 HR HRP20231100TT patent/HRP20231100T1/hr unknown
- 2014-11-13 CN CN202110168758.6A patent/CN112898210B/zh active Active
- 2014-11-13 ES ES19204562T patent/ES2957314T3/es active Active
- 2014-11-13 CN CN201480072954.1A patent/CN105899492B/zh active Active
- 2014-11-13 SI SI201431455T patent/SI3068770T1/sl unknown
- 2014-11-13 KR KR1020227034215A patent/KR102698200B1/ko active Active
- 2014-11-13 ES ES14863015T patent/ES2765511T3/es active Active
- 2014-11-13 MY MYPI2019002660A patent/MY191759A/en unknown
- 2014-11-13 JP JP2016530862A patent/JP6374503B2/ja active Active
- 2014-11-13 MX MX2016006299A patent/MX367620B/es active IP Right Grant
- 2014-11-13 NZ NZ720805A patent/NZ720805A/en unknown
- 2014-11-13 CN CN201910735465.4A patent/CN110590606B/zh active Active
- 2014-11-13 CA CA2930870A patent/CA2930870C/en active Active
- 2014-11-13 EP EP19204562.3A patent/EP3656764B1/en active Active
- 2014-11-13 AU AU2014348570A patent/AU2014348570B2/en active Active
- 2014-11-13 SG SG10201901578UA patent/SG10201901578UA/en unknown
- 2014-11-13 MY MYPI2016000911A patent/MY174153A/en unknown
- 2014-11-13 HU HUE19204562A patent/HUE063095T2/hu unknown
- 2014-11-13 WO PCT/US2014/065567 patent/WO2015073739A1/en not_active Ceased
- 2014-11-13 CA CA3207199A patent/CA3207199A1/en active Pending
- 2014-11-13 RU RU2016123365A patent/RU2702355C1/ru active
- 2014-11-13 EP EP14863015.5A patent/EP3068770B1/en active Active
- 2014-11-13 PL PL14863015T patent/PL3068770T3/pl unknown
- 2014-11-13 KR KR1020167015742A patent/KR102493603B1/ko active Active
- 2014-11-13 PL PL19204562.3T patent/PL3656764T3/pl unknown
- 2014-11-13 HR HRP20192340TT patent/HRP20192340T1/hr unknown
- 2014-11-14 AR ARP140104291A patent/AR098427A1/es not_active Application Discontinuation
-
2016
- 2016-05-15 IL IL245636A patent/IL245636B/en active IP Right Grant
- 2016-05-19 ZA ZA2016/03434A patent/ZA201603434B/en unknown
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2017
- 2017-11-20 JP JP2017222867A patent/JP6634428B2/ja active Active
- 2017-11-30 US US15/827,985 patent/US10435378B2/en active Active
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2019
- 2019-04-09 AU AU2019202461A patent/AU2019202461B2/en active Active
- 2019-08-28 JP JP2019155667A patent/JP6857219B2/ja active Active
- 2019-08-29 US US16/555,842 patent/US10858324B2/en active Active
- 2019-12-11 IL IL271331A patent/IL271331B/en active IP Right Grant
-
2020
- 2020-05-11 ZA ZA2020/02611A patent/ZA202002611B/en unknown
-
2021
- 2021-02-24 IL IL281072A patent/IL281072B/en unknown
- 2021-03-19 JP JP2021045573A patent/JP7377828B2/ja active Active
- 2021-04-12 AU AU2021202196A patent/AU2021202196A1/en not_active Abandoned
-
2022
- 2022-11-24 AU AU2022275477A patent/AU2022275477A1/en not_active Abandoned
-
2024
- 2024-08-16 AU AU2024205845A patent/AU2024205845A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |