[go: up one dir, main page]

MX2016005174A - Composiciones para uso en la prevencion y el tratamiento de enfermedades neurodegenerativas y dolor. - Google Patents

Composiciones para uso en la prevencion y el tratamiento de enfermedades neurodegenerativas y dolor.

Info

Publication number
MX2016005174A
MX2016005174A MX2016005174A MX2016005174A MX2016005174A MX 2016005174 A MX2016005174 A MX 2016005174A MX 2016005174 A MX2016005174 A MX 2016005174A MX 2016005174 A MX2016005174 A MX 2016005174A MX 2016005174 A MX2016005174 A MX 2016005174A
Authority
MX
Mexico
Prior art keywords
adenosine
methyl
pain
prevention
compounds
Prior art date
Application number
MX2016005174A
Other languages
English (en)
Other versions
MX367707B (es
Inventor
Fang Jim-Min
Lian LIN Yun-
Hsin LIN Jung-
Jung LIN Chun-
Chern Yijuang
Kuei HUANG Nai-
Li WANG Hung-
Pang-hsien TU Benjamin
Cheng Chen Chih-
Original Assignee
Academia Sinica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academia Sinica filed Critical Academia Sinica
Publication of MX2016005174A publication Critical patent/MX2016005174A/es
Publication of MX367707B publication Critical patent/MX367707B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se revelan compuestos para el uso en la prevención y el tratamiento de una enfermedad neurodegenerativa y el dolor. En una realización de la invención, el compuesto se selecciona del grupo que consiste en N6-[(3-halotien-2-il)metil]adenosina, N6-[(4-halotien-2-il)metil]adenosina y N6-[(5-halotien-2-il)metil] adenosina. En otra realización de la invención, el compuesto se selecciona del grupo que consiste en N6-[(2-bromotien-3-il)metil]a denosina, N6-[(4-bromotien-3-il)metil]adenosina, N6-[(5-bromotien-3-il)metil]adenosina, N6-[(2-clorotien-2-il)metil ]adenosina, N6-[(4-clorotien-3-il)metil]adenosina y N6-[(clorotien-3-il)meti]adenosina. También se revelan métodos para fabricar y usar los mismos.
MX2016005174A 2013-10-23 2014-10-22 Composiciones para uso en la prevencion y el tratamiento de enfermedades neurodegenerativas y dolor. MX367707B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361894699P 2013-10-23 2013-10-23
PCT/US2014/061734 WO2015061426A1 (en) 2013-10-23 2014-10-22 Compounds for use in prevention and treatment of neurodegenerative diseases and pain

Publications (2)

Publication Number Publication Date
MX2016005174A true MX2016005174A (es) 2016-08-11
MX367707B MX367707B (es) 2019-09-03

Family

ID=52993493

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016005174A MX367707B (es) 2013-10-23 2014-10-22 Composiciones para uso en la prevencion y el tratamiento de enfermedades neurodegenerativas y dolor.

Country Status (14)

Country Link
US (1) US10301348B2 (es)
EP (1) EP3060566B1 (es)
JP (1) JP6534997B2 (es)
KR (1) KR102313314B1 (es)
CN (1) CN106414456B (es)
AU (1) AU2014340114B2 (es)
BR (1) BR112016008901B1 (es)
CA (1) CA2927699C (es)
IL (1) IL245103B (es)
MX (1) MX367707B (es)
RU (1) RU2695358C2 (es)
SG (1) SG11201603063WA (es)
WO (1) WO2015061426A1 (es)
ZA (1) ZA201603118B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180030461A (ko) * 2015-05-29 2018-03-23 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 연장된 뉴클레오타이드 반복을 포함하는 유전자의 유해 영향 감소를 위한 뉴클레오사이드 제제
JP7136786B2 (ja) * 2017-01-27 2022-09-13 アカデミア シニカ 痛みの予防および治療に使用するための鎮痛効果を有する化合物
CA3250090A1 (en) * 2022-02-10 2023-08-17 Academia Sinica METHOD FOR TREATMENT OF A SPINAL CORD INJURY AND CORRESPONDING COMPOSITION
TW202416962A (zh) * 2022-07-07 2024-05-01 中央研究院 治療思覺失調症之方法及用於其中之組成物
CA3275345A1 (en) * 2022-12-29 2024-07-04 Academia Sinica METHODS FOR TREATING SLEEP DISORDERS AND COMPOSITION INTENDED FOR USE THEREOF
KR20250165367A (ko) * 2023-03-17 2025-11-25 아카데미아 시니카 결절성 경화증 또는 간질 치료 방법 및 이에 사용하기 위한 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003148A2 (en) * 1986-10-31 1988-05-05 Warner-Lambert Company Heteroaromatic derivatives of adenoside
US5034381A (en) * 1988-01-07 1991-07-23 Ciba-Geigy Corporation 2-(substituted amino) adenosines as antihypertensives
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
EP0550631B1 (en) * 1990-09-25 1997-01-02 Rhone-Poulenc Rorer International (Holdings) Inc. Compounds having antihypertensive and anti-ischemic properties
UY27939A1 (es) * 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
EP2498774B1 (en) * 2009-11-13 2017-10-11 Academia Sinica Dual-action compounds targeting adenosine a2a receptor and adenosine transporter for prevention and treatment of neurodegenerative diseases
JP2013513551A (ja) * 2009-12-10 2013-04-22 中国医学科学院葯物研究所 Ｎ６−置換アデノシン誘導体とｎ６−置換アデニン誘導体の鎮静、催眠，抗うつ，抗痙攣，抗てんかん，抗パーキンソン病と認知証予防・治療の用途
CA2897675C (en) * 2012-02-09 2017-07-18 Brandbumps, Llc Decorative detectable warning panel having improved grip
EP2849566B1 (en) * 2012-02-11 2018-04-04 Academia Sinica Adenosine analogues for the treatment of pain

Also Published As

Publication number Publication date
BR112016008901B1 (pt) 2022-08-23
JP2016535019A (ja) 2016-11-10
CA2927699C (en) 2022-07-05
EP3060566A4 (en) 2017-06-14
US10301348B2 (en) 2019-05-28
EP3060566A1 (en) 2016-08-31
JP6534997B2 (ja) 2019-06-26
KR102313314B1 (ko) 2021-10-19
SG11201603063WA (en) 2016-05-30
RU2016118282A3 (es) 2018-06-18
MX367707B (es) 2019-09-03
AU2014340114A1 (en) 2016-05-26
RU2695358C2 (ru) 2019-07-23
IL245103A0 (en) 2016-06-30
ZA201603118B (en) 2019-04-24
NZ719740A (en) 2021-02-26
AU2014340114B2 (en) 2018-10-18
IL245103B (en) 2019-02-28
CN106414456A (zh) 2017-02-15
CA2927699A1 (en) 2015-04-30
BR112016008901A2 (pt) 2020-05-12
KR20160086852A (ko) 2016-07-20
CN106414456B (zh) 2018-12-14
US20160264613A1 (en) 2016-09-15
RU2016118282A (ru) 2017-11-28
WO2015061426A1 (en) 2015-04-30
EP3060566B1 (en) 2018-09-05

Similar Documents

Publication Publication Date Title
JOP20200192A1 (ar) أجسام مضادة لـ tigit
IL264049A (en) Compounds, preparations and methods for treating the disease
CY1120862T1 (el) Παραγοντες επαγωγης αποπτωσης για τη θεραπευτικη αγωγη καρκινου και ανοσων και αυτοανοσων ασθενειων
PH12016501107B1 (en) Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
IL264156A (en) Compounds, preparations and methods for treating the disease
PH12015502788A1 (en) Antibody formulations and methods
PH12015501648A1 (en) 2-aminopyrimidine derivatives for the treatment of viral infections
MX2015012502A (es) Inhibidores de proteina cinasa dependiente de adn.
MY192927A (en) Fused bicyclic compounds for the treatment of disease
EP2967049A4 (en) Methods, compounds, and compositions for the treatment of angiotensin-related diseases
MX2017008456A (es) Compuestos biciclicos fusionados para el tratamiento de enfermedades.
EA201690513A1 (ru) Комбинация ингибитора mek и ингибитора erk для применения в лечении гиперпролиферативных заболеваний
MX2016005174A (es) Composiciones para uso en la prevencion y el tratamiento de enfermedades neurodegenerativas y dolor.
EP3046582A4 (en) Uses of modified mullerian inhibiting substance (mis) proteins for the treatment of neurodegenerative diseases
MX382092B (es) Compuestos heterocíclicos para el tratamiento de enfermedades.
HK1254231A1 (zh) 米托-和厚朴酚化合物及其合成方法和用途
MX370897B (es) Compuestos bicíclicos fusionados para el tratamiento de enfermedades,
EP2994156A4 (en) Compounds, compositions and methods for the treatment of diseases through inhibiting tgf- activity
MX2016002930A (es) Moduladores del receptor x hepatico (lxr).
MX371343B (es) Moduladores del receptor x hepatico (lxr).
MX2018014034A (es) Compuestos bicíclicos fusionados para el tratamiento de enfermedades.

Legal Events

Date Code Title Description
FG Grant or registration