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MX2016003135A - Compuestos de piridazinona y usos de los mismos. - Google Patents

Compuestos de piridazinona y usos de los mismos.

Info

Publication number
MX2016003135A
MX2016003135A MX2016003135A MX2016003135A MX2016003135A MX 2016003135 A MX2016003135 A MX 2016003135A MX 2016003135 A MX2016003135 A MX 2016003135A MX 2016003135 A MX2016003135 A MX 2016003135A MX 2016003135 A MX2016003135 A MX 2016003135A
Authority
MX
Mexico
Prior art keywords
pyridazinone compounds
disclosed
methods
infection
orthomyxovirus
Prior art date
Application number
MX2016003135A
Other languages
English (en)
Other versions
MX370085B (es
Inventor
Beigelman Leonid
Than Hendricks Robert
Katherine Stevens Sarah
Dimitrova Stoycheva Antitsa
Deval Jerome
Original Assignee
Alios Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alios Biopharma Inc filed Critical Alios Biopharma Inc
Publication of MX2016003135A publication Critical patent/MX2016003135A/es
Publication of MX370085B publication Critical patent/MX370085B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente se describen compuestos de piridazinona, composiciones farmacéuticas que incluyen uno o más compuestos de piridazinona, y métodos para sintetizar los mismos; también en la presente se describen métodos para mejorar y/o tratar una enfermedad y/o una condición, incluyendo una infección por ortomixovirus, con compuestos de piridazinona; los ejemplos de una infección viral por ortomixovirus incluye una infección de influenza.
MX2016003135A 2013-09-12 2014-09-10 Compuestos de piridazinona y usos de los mismos. MX370085B (es)

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CN105722831A (zh) 2016-06-29
KR102286860B1 (ko) 2021-08-05
NZ717586A (en) 2021-09-24
EP3030549B1 (en) 2019-02-20
IL244434B (en) 2020-09-30
AU2014318837B2 (en) 2019-05-30
SI3030549T1 (sl) 2019-08-30
HK1225382A1 (zh) 2017-09-08
US10364226B2 (en) 2019-07-30
EA201690371A1 (ru) 2016-08-31
WO2015038660A1 (en) 2015-03-19
PH12016500492A1 (en) 2016-05-16
DK3030549T3 (da) 2019-05-13
EP3030549B8 (en) 2019-04-10
AU2014318837A1 (en) 2016-03-24
PH12016500492B1 (en) 2016-05-16
US20160221963A1 (en) 2016-08-04
ES2724581T3 (es) 2019-09-12
CA2922943A1 (en) 2015-03-19
JP2016530315A (ja) 2016-09-29
LT3030549T (lt) 2019-06-25
EA034868B1 (ru) 2020-03-31
IL244434A0 (en) 2016-04-21
HUE043349T2 (hu) 2019-08-28
MX370085B (es) 2019-11-29
EP3030549A4 (en) 2017-03-15
EP3030549A1 (en) 2016-06-15
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