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MX2015015451A - Celulas como un modelo para identificar moduladores del gusto potenciales. - Google Patents

Celulas como un modelo para identificar moduladores del gusto potenciales.

Info

Publication number
MX2015015451A
MX2015015451A MX2015015451A MX2015015451A MX2015015451A MX 2015015451 A MX2015015451 A MX 2015015451A MX 2015015451 A MX2015015451 A MX 2015015451A MX 2015015451 A MX2015015451 A MX 2015015451A MX 2015015451 A MX2015015451 A MX 2015015451A
Authority
MX
Mexico
Prior art keywords
cells
model
identify potential
taste modulators
potential taste
Prior art date
Application number
MX2015015451A
Other languages
English (en)
Inventor
Kurash Yuliya
Gravina Stephen
Original Assignee
Pepsico Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pepsico Inc filed Critical Pepsico Inc
Publication of MX2015015451A publication Critical patent/MX2015015451A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La co-expresión de T1R2 y T1R3 da por resultado un receptor del gusto que responde a los estímulos del gusto dulce, incluyendo edulcorantes que ocurren naturalmente y artificiales. Las células tales como U2-OS, que expresan un receptor de dulce convencional, se pueden utilizar en ensayos a base de células para detectar respuestas celulares a los estimulantes del gusto.
MX2015015451A 2013-05-10 2014-05-09 Celulas como un modelo para identificar moduladores del gusto potenciales. MX2015015451A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361821943P 2013-05-10 2013-05-10
PCT/US2014/037511 WO2014183044A1 (en) 2013-05-10 2014-05-09 Cells as a model to identify potential taste modulators

Publications (1)

Publication Number Publication Date
MX2015015451A true MX2015015451A (es) 2016-09-09

Family

ID=51867772

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015451A MX2015015451A (es) 2013-05-10 2014-05-09 Celulas como un modelo para identificar moduladores del gusto potenciales.

Country Status (10)

Country Link
US (1) US10107794B2 (es)
EP (1) EP2994477A4 (es)
JP (1) JP6367315B2 (es)
CN (1) CN105339384A (es)
AU (1) AU2014262543B2 (es)
CA (1) CA2912023C (es)
HK (1) HK1218301A1 (es)
MX (1) MX2015015451A (es)
RU (2) RU2690456C2 (es)
WO (1) WO2014183044A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2911189A1 (en) 2013-05-10 2014-11-13 Pepsico, Inc. Taste receptor internalization assay
BR112023021573A2 (pt) 2021-05-07 2023-12-19 Firmenich Incorporated Células expressando receptores de sabor amargo e usos das mesmas
EP4473004A1 (en) 2022-02-11 2024-12-11 Firmenich Incorporated Cells expressing umami taste receptors and uses thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
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US6759206B1 (en) 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
ATE231617T1 (de) 1998-07-13 2003-02-15 Cellomics Inc Auf zellen basiertes screening-system
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
CA2384777A1 (en) 1999-09-10 2001-03-15 Charles S. Zuker T2r taste receptor family
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US7022488B2 (en) 2003-02-03 2006-04-04 Senomyx, Inc. Functional coupling of T1Rs and T2Rs by Gi proteins, and cells-based assays for the identification of T1R and T2R modulators
WO2003025137A2 (en) * 2001-09-18 2003-03-27 Irm, Llc Sweet taste receptors
EP1572960A4 (en) 2002-07-29 2009-03-18 Senomyx Inc IDENTIFICATION OF A NEW BITTER RECEPTOR, T2R76
ATE393778T1 (de) * 2002-12-18 2008-05-15 Givaudan Sa Chimäre alpha q-gustducin g-proteine
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WO2006040337A1 (en) 2004-10-13 2006-04-20 Evotec Technologies Gmbh Method for identifying compounds that affect a transport of a protein through a membrane trafficking pathway
CN101065479A (zh) 2004-10-15 2007-10-31 蒙奈尔化学感觉中心 培养哺乳动物味细胞的方法
WO2006099005A1 (en) 2005-03-09 2006-09-21 Trustees Of Dartmouth College Method for identifying agents which modulate gtpase activity involved in insulin-stimulated glut4 translocation
CN101605810B (zh) 2005-10-20 2013-07-17 塞诺米克斯公司 嵌合的人甜味-鲜味和鲜味-甜味受体
US20070218456A1 (en) 2006-02-08 2007-09-20 Invitrogen Corporation Cellular assays for signaling receptors
EP2047254B1 (en) * 2006-04-20 2015-10-28 Givaudan SA Method relating to sweetness enhancement
JP5225986B2 (ja) * 2006-06-19 2013-07-03 ジボダン エス エー 核酸、ポリペプチドおよびその利用
AU2007279276A1 (en) * 2006-07-26 2008-01-31 The Coca-Cola Company Methods for identifying modulators of RGS21 activity, compositions comprising an RGS21 modulator, and methods of use thereof to modulate taste sensation
EP2137322B1 (en) 2007-03-30 2013-02-27 Givaudan SA Methods to identify tas2r modulators
CN101998989A (zh) * 2007-06-08 2011-03-30 塞诺米克斯公司 Trpml3(mcoln3)作为咸味受体的鉴定及在用于鉴定调控钠转运、吸收或排泄和/或醛固酮和/或血管加压素的产生或释放的味觉(咸味)调节剂和/或治疗剂的测定中的用途
WO2009008950A2 (en) 2007-06-08 2009-01-15 Senomyx, Inc. Identification of trpml3 (mcoln3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release
HUE025137T2 (en) 2007-08-21 2016-01-28 Senomyx Inc Compositions are bitter taste blocking (blocking) compounds
KR101751074B1 (ko) * 2009-02-02 2017-06-26 크로모셀 코포레이션 신규한 세포주와 방법
WO2011067202A1 (en) 2009-12-02 2011-06-09 Unilever Nv Improved method for screening a potential modulator compound of a taste receptor
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EP2667885B1 (en) 2011-01-25 2018-08-08 Monell Chemical Senses Center Compositions and methods for providing or modulating sweet taste and methods of screening therefor
WO2013022948A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
CA2911189A1 (en) 2013-05-10 2014-11-13 Pepsico, Inc. Taste receptor internalization assay

Also Published As

Publication number Publication date
RU2018100104A (ru) 2019-02-20
AU2014262543B2 (en) 2017-07-20
RU2018100104A3 (es) 2019-02-20
JP6367315B2 (ja) 2018-08-01
HK1218301A1 (zh) 2017-02-10
JP2016519931A (ja) 2016-07-11
US10107794B2 (en) 2018-10-23
RU2015152840A (ru) 2017-06-16
US20160091488A1 (en) 2016-03-31
EP2994477A4 (en) 2017-03-22
AU2014262543A1 (en) 2015-11-26
CA2912023C (en) 2018-10-23
WO2014183044A1 (en) 2014-11-13
RU2644222C2 (ru) 2018-02-08
CN105339384A (zh) 2016-02-17
RU2690456C2 (ru) 2019-06-03
EP2994477A1 (en) 2016-03-16
CA2912023A1 (en) 2014-11-13

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