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MX2015015290A - Compuestos furanona como inhibidores de quinasa. - Google Patents

Compuestos furanona como inhibidores de quinasa.

Info

Publication number
MX2015015290A
MX2015015290A MX2015015290A MX2015015290A MX2015015290A MX 2015015290 A MX2015015290 A MX 2015015290A MX 2015015290 A MX2015015290 A MX 2015015290A MX 2015015290 A MX2015015290 A MX 2015015290A MX 2015015290 A MX2015015290 A MX 2015015290A
Authority
MX
Mexico
Prior art keywords
furanone compounds
kinase inhibitors
compounds
treatment
furanone
Prior art date
Application number
MX2015015290A
Other languages
English (en)
Inventor
Minsheng Zhang
Dong Liu
Original Assignee
Eternity Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eternity Bioscience Inc filed Critical Eternity Bioscience Inc
Publication of MX2015015290A publication Critical patent/MX2015015290A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención provee compuestos furanona novedosos, o sales farmacéuticamente aceptables, solvatos o profármacos de los mismos, como inhibidores de Raf quinasa, especialmente de BRAF quinasa, que son agentes terapéuticos útiles para el tratamiento de enfermedades o trastornos relacionados con Raf quinasa tales como melanomas, cánceres y leucemia. La invención también provee métodos y procesos para preparar estos compuestos furanona novedosos, composiciones farmacéuticas que contienen estos compuestos furanona y métodos de tratamiento que usan estos compuestos furanona.
MX2015015290A 2013-05-08 2014-05-08 Compuestos furanona como inhibidores de quinasa. MX2015015290A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361820853P 2013-05-08 2013-05-08
PCT/US2014/037247 WO2014182873A1 (en) 2013-05-08 2014-05-08 Furanone compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2015015290A true MX2015015290A (es) 2016-02-22

Family

ID=51867735

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015290A MX2015015290A (es) 2013-05-08 2014-05-08 Compuestos furanona como inhibidores de quinasa.

Country Status (8)

Country Link
US (1) US9458140B2 (es)
EP (1) EP2994127B1 (es)
CN (1) CN105163733B (es)
AU (1) AU2014262658B2 (es)
CA (1) CA2909578C (es)
MX (1) MX2015015290A (es)
TW (1) TWI634114B (es)
WO (1) WO2014182873A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2722667C2 (ru) * 2016-03-10 2020-06-02 Лутрис Фарма Лтд. Использование ингибиторов braf для лечения кожных реакций

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020124397A1 (en) 2018-12-19 2020-06-25 Inventisbio Shanghai Ltd. C-terminal src kinase inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4606756A (en) * 1984-10-26 1986-08-19 Chevron Research Company Herbicidal 2-(nitrogen heterocycle)5-amino-3-oxo-4-(substituted-phenyl)-2,3-dihydrofurans
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
KR0119908B1 (ko) * 1994-04-18 1997-10-30 강박광 3(2h)-푸란온 유도체
EP1109799B1 (en) * 1999-04-14 2003-12-17 Pacific Corporation 4,5-diaryl-3(2h)-furanone derivatives as cyclooxygenase-2 inhibitors
EP2121669A2 (en) * 2007-01-30 2009-11-25 Biogen Idec MA, Inc. Furanone compounds and methods of making and using the same
UA103319C2 (en) * 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
MX2011000175A (es) * 2008-06-25 2011-06-27 Envivo Pharmaceuticals Inc Compuestos heterociclicos 1,2-di-substituidos.
PE20120900A1 (es) * 2009-05-07 2012-08-14 Envivo Pharmaceuticals Inc Compuestos heterociclicos de fenoximetilo
AR077975A1 (es) * 2009-08-28 2011-10-05 Irm Llc Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
TW201512201A (zh) * 2013-03-14 2015-04-01 Forum Pharmaceuticals Inc 化合物的多晶型及鹽類

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2722667C2 (ru) * 2016-03-10 2020-06-02 Лутрис Фарма Лтд. Использование ингибиторов braf для лечения кожных реакций

Also Published As

Publication number Publication date
WO2014182873A1 (en) 2014-11-13
EP2994127B1 (en) 2019-10-09
CN105163733A (zh) 2015-12-16
EP2994127A4 (en) 2016-12-14
CA2909578A1 (en) 2014-11-13
US20160096825A1 (en) 2016-04-07
US9458140B2 (en) 2016-10-04
EP2994127A1 (en) 2016-03-16
CA2909578C (en) 2021-07-06
AU2014262658B2 (en) 2018-08-02
TWI634114B (zh) 2018-09-01
HK1217654A1 (zh) 2017-01-20
TW201506021A (zh) 2015-02-16
AU2014262658A1 (en) 2015-11-05
CN105163733B (zh) 2019-05-31

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