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MX2015008399A - Derivado de benzoazepina novedoso y uso medico del mismo. - Google Patents

Derivado de benzoazepina novedoso y uso medico del mismo.

Info

Publication number
MX2015008399A
MX2015008399A MX2015008399A MX2015008399A MX2015008399A MX 2015008399 A MX2015008399 A MX 2015008399A MX 2015008399 A MX2015008399 A MX 2015008399A MX 2015008399 A MX2015008399 A MX 2015008399A MX 2015008399 A MX2015008399 A MX 2015008399A
Authority
MX
Mexico
Prior art keywords
group
lower alkyl
alkyl group
substituted
formula
Prior art date
Application number
MX2015008399A
Other languages
English (en)
Other versions
MX362478B (es
Inventor
Katsunori Kitamoto
Nobuyoshi Kasugai
Hiroyo Kataoka
Yasushi OHSAWA
Yuka Kuno
Hiroki Fujieda
Keita Sakai
Hiroki Nagano
Naoki Takahashi
Toru IZUCHI
Mitsuaki Takeuchi
Daisuke KURUMAZUKA
Toshiyuki Miyazawa
Satoko Harada
Yukiyasu Asano
Yurie Yamada
Morio Okabe
Izumi GOTOH
Original Assignee
Sanwa Kagaku Kenkyusho Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanwa Kagaku Kenkyusho Co filed Critical Sanwa Kagaku Kenkyusho Co
Publication of MX2015008399A publication Critical patent/MX2015008399A/es
Publication of MX362478B publication Critical patent/MX362478B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un objetivo de la invención actual es a proporcionar un compuesto que tenga una actividad agonista del receptor V2. Se proporciona una composición farmacéutica que contiene, como un ingrediente activo, un compuesto representado por la fórmula general (I) descrita enseguida: Fórmula 1 (ver Fórmula) en donde R1 es la fórmula descrita enseguida: Fórmula 2 (ver Fórmula) (en donde A es un grupo alquileno inferior que puede sustituirse con un grupo alquilo inferior, o similares; R6 es un átomo de hidrógeno, o similares; R7 es un grupo hidroxilo, un grupo heterocíclico aromático que puede sustituirse con un grupo alquilo inferior, un grupo carbamoilo, o similares); R2 es un átomo de hidrógeno o un grupo alquilo inferior; R3 es un grupo alquilo inferior que puede sustituirse con 1 hasta 3 átomos de flúor, o un átomo de halógeno; R4 es un grupo heterocíclico monocíclico aromático de cinco miembros, un grupo heterocíclico monocíclico no aromático de cinco miembros, o similares, (con la condición de que cada uno de estos grupos heterocíclicos contiene al menos un átomo de nitrógeno y puede sustituirse con un grupo alquilo inferior); y R5 es un grupo alquilo inferior, un átomo de halógeno, o similares, o una sal farmacológicamente aceptable del mismo.
MX2015008399A 2012-12-26 2013-12-26 Derivado de benzoazepina novedoso y uso medico del mismo. MX362478B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012281908 2012-12-26
PCT/JP2013/084937 WO2014104209A1 (ja) 2012-12-26 2013-12-26 新規ベンゾアゼピン誘導体及びその医薬用途

Publications (2)

Publication Number Publication Date
MX2015008399A true MX2015008399A (es) 2015-09-23
MX362478B MX362478B (es) 2019-01-11

Family

ID=51021283

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015008399A MX362478B (es) 2012-12-26 2013-12-26 Derivado de benzoazepina novedoso y uso medico del mismo.

Country Status (14)

Country Link
US (1) US9586905B2 (es)
EP (1) EP2940008B1 (es)
JP (2) JP5968466B2 (es)
KR (1) KR101983880B1 (es)
CN (1) CN104884436B (es)
AU (1) AU2013367084B2 (es)
BR (1) BR112015015663A2 (es)
CA (1) CA2889239C (es)
DK (1) DK2940008T3 (es)
ES (1) ES2633981T3 (es)
MX (1) MX362478B (es)
PL (1) PL2940008T3 (es)
RU (1) RU2642783C2 (es)
WO (1) WO2014104209A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104884436B (zh) * 2012-12-26 2017-06-13 株式会社三和化学研究所 苯并氮杂衍生物及其医药用途
JPWO2020171055A1 (es) * 2019-02-19 2020-08-27
JP2022055368A (ja) * 2019-02-19 2022-04-08 株式会社三和化学研究所 ベンゾアゼピン誘導体の製造方法及びその中間体

Family Cites Families (21)

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US4952573A (en) * 1988-03-23 1990-08-28 Laboratoirs Alcon S.A. Compounds having GABA like activity, and use of same in tissue irrigating solutions
JP2905909B2 (ja) * 1991-04-19 1999-06-14 大塚製薬株式会社 バソプレシン拮抗剤
WO1991005549A1 (en) * 1989-10-20 1991-05-02 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
US5258510A (en) 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5753677A (en) * 1989-10-20 1998-05-19 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
US5985869A (en) 1989-10-20 1999-11-16 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
DE69535486T2 (de) 1994-06-15 2008-04-10 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclische Verbindungen verwendbar als Vasopressin- oder Oxytocin-Modulatoren
TW359669B (en) 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
JP2964031B2 (ja) 1995-12-15 1999-10-18 大塚製薬株式会社 ベンゾアゼピン誘導体
JPH09221476A (ja) 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd 医薬組成物
JPH111456A (ja) 1997-06-13 1999-01-06 Otsuka Pharmaceut Co Ltd アミド誘導体
JP2926335B2 (ja) 1997-06-13 1999-07-28 大塚製薬株式会社 医薬組成物
CN1323076C (zh) * 2001-11-16 2007-06-27 安斯泰来制药有限公司 4,4－二氟－1,2,3,4－四氢－5h－1－苯并氮杂䓬衍生物或其盐
JP4238978B2 (ja) 2003-04-22 2009-03-18 大塚製薬株式会社 ベンゾアゼピン化合物及びその製造法
CN101279971A (zh) * 2003-04-28 2008-10-08 安斯泰来制药有限公司 4,4－二氟－1,2,3,4－四氢－5h－1－苯并氮杂䓬衍生物或其盐
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JP5009785B2 (ja) 2005-03-25 2012-08-22 キッセイ薬品工業株式会社 ウレア誘導体、それを含有する医薬組成物およびそれらの医薬用途
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CN104884436B (zh) * 2012-12-26 2017-06-13 株式会社三和化学研究所 苯并氮杂衍生物及其医药用途

Also Published As

Publication number Publication date
CN104884436B (zh) 2017-06-13
JPWO2014104209A1 (ja) 2017-01-19
EP2940008A4 (en) 2016-05-18
CN104884436A (zh) 2015-09-02
MX362478B (es) 2019-01-11
US20150291533A1 (en) 2015-10-15
KR101983880B1 (ko) 2019-05-29
AU2013367084B2 (en) 2017-06-08
HK1208676A1 (en) 2016-03-11
WO2014104209A1 (ja) 2014-07-03
JP5968466B2 (ja) 2016-08-10
JP6231621B2 (ja) 2017-11-15
EP2940008B1 (en) 2017-05-17
PL2940008T3 (pl) 2017-10-31
KR20150098614A (ko) 2015-08-28
CA2889239C (en) 2020-10-27
EP2940008A1 (en) 2015-11-04
CA2889239A1 (en) 2014-07-03
US9586905B2 (en) 2017-03-07
ES2633981T3 (es) 2017-09-26
DK2940008T3 (en) 2017-08-07
JP2016199575A (ja) 2016-12-01
BR112015015663A2 (pt) 2017-07-11
AU2013367084A1 (en) 2015-05-28
RU2642783C2 (ru) 2018-01-26
RU2015131020A (ru) 2017-01-30

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