[go: up one dir, main page]

MX2015004362A - Derivados de ketamina. - Google Patents

Derivados de ketamina.

Info

Publication number
MX2015004362A
MX2015004362A MX2015004362A MX2015004362A MX2015004362A MX 2015004362 A MX2015004362 A MX 2015004362A MX 2015004362 A MX2015004362 A MX 2015004362A MX 2015004362 A MX2015004362 A MX 2015004362A MX 2015004362 A MX2015004362 A MX 2015004362A
Authority
MX
Mexico
Prior art keywords
ketamine derivatives
methods
derivatives
ketamine
formula
Prior art date
Application number
MX2015004362A
Other languages
English (en)
Inventor
James Wallace Sleigh
William Alexander Denny
Jiney Jose
Swarnalatha Akuratiya Gamage
Martyn Gregory Harvey
Logan James Voss
Original Assignee
Auckland Uniservices Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd
Publication of MX2015004362A publication Critical patent/MX2015004362A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)

Abstract

La presente invención se refiere a derivados de ketamina de la fórmula (I), o composiciones farmacéuticas que comprenden los mismos, y métodos para tratar dolor, que comprende administrar las mismas, y su uso en la fabricación de medicamentos para tratar dolor. La presente invención se refiere también a los métodos para anestesiar y métodos para sedar a un sujeto que comprende administrar derivados de ketamina de la fórmula (II).
MX2015004362A 2012-10-08 2013-10-08 Derivados de ketamina. MX2015004362A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ60288512 2012-10-08
NZ61120213 2013-05-28
PCT/IB2013/059191 WO2014057414A1 (en) 2012-10-08 2013-10-08 Ketamine derivatives

Publications (1)

Publication Number Publication Date
MX2015004362A true MX2015004362A (es) 2015-12-08

Family

ID=50476991

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004362A MX2015004362A (es) 2012-10-08 2013-10-08 Derivados de ketamina.

Country Status (13)

Country Link
US (3) US20150259277A1 (es)
EP (1) EP2903963A4 (es)
JP (2) JP6309957B2 (es)
KR (1) KR20150065873A (es)
CN (1) CN104837810B (es)
AU (1) AU2013328280B2 (es)
BR (1) BR112015007647A2 (es)
CA (1) CA2922340A1 (es)
EA (1) EA201590697A1 (es)
HK (1) HK1212673A1 (es)
IN (1) IN2015DN03854A (es)
MX (1) MX2015004362A (es)
WO (1) WO2014057414A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150259277A1 (en) * 2012-10-08 2015-09-17 James Wallace Sleigh Ketamine Derivatives
US20160332962A1 (en) * 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
US11191734B2 (en) 2015-06-27 2021-12-07 Shenox Pharmaceuticals, Llc Ketamine transdermal delivery system
US11111210B2 (en) 2015-11-18 2021-09-07 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
US11827606B2 (en) 2015-11-18 2023-11-28 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
CN115108927A (zh) 2016-03-25 2022-09-27 美国政府健康及人类服务部 (2r,6r)-羟基去甲氯胺酮和(2s,6s)-羟基去甲氯胺酮的晶型和合成方法
CN111836798B (zh) 2018-01-10 2022-04-15 凯瑞康宁生物工程（武汉）有限公司 氯胺酮的前药、其组合物和用途
EP3761970A4 (en) * 2018-03-26 2022-06-08 Cellix Bio Private Limited COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL DISEASES
US11186539B2 (en) 2018-06-04 2021-11-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Process for synthesis and purification of (2R,6R)-hydroxynorketamine
CN112125816A (zh) * 2020-03-17 2020-12-25 国药集团工业有限公司 一种氯胺酮、其衍生物或其盐的消旋化方法
DE102021105268A1 (de) * 2021-03-04 2022-09-08 Lts Lohmann Therapie-Systeme Ag. Oraler Dünnfilm
TWI844074B (zh) 2021-08-13 2024-06-01 凱瑞康寧生技股份有限公司 氯胺酮衍生物之醫藥組成物及口服劑型
CN115677444A (zh) * 2022-10-26 2023-02-03 公安部第三研究所 同位素毒品代谢物标记化合物及其制备方法、用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254124A (en) * 1962-06-29 1966-05-31 Parke Davis & Co Aminoketones and methods for their production
GB1134146A (en) * 1967-09-15 1968-11-20 Parke Davis & Co New organic amines and methods for their production
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5466700A (en) 1993-08-30 1995-11-14 Glaxo Wellcome Inc. Anesthetic use of N-phenyl-N-(4-piperidinyl)amides
US5866591A (en) 1996-09-11 1999-02-02 Glaxo Wellcome Inc. Stable formulations of remifentanil
JP2004501067A (ja) * 2000-01-28 2004-01-15 ローム　アンド　ハース　カンパニー 高められた特性をもつ医薬
US20040248963A1 (en) 2001-11-23 2004-12-09 Bueno Melendo Ana Belen Prodrugs of excitatory amino acids
ATE492565T1 (de) 2002-01-31 2011-01-15 Randox Lab Ltd Immunogene, antikörper und konjugate für ketamin und dessen metaboliten
JP2006510618A (ja) * 2002-11-18 2006-03-30 ヤウポン セラピューティクス，インコーポレーテッド ノルケタミンおよびケタミン／ノルケタミンプロドラッグの鎮痛的使用
BRPI0520588B8 (pt) * 2005-09-28 2021-05-25 Auris Medical Ag uso de composições farmacêuticas para o tratamento de doenças do ouvido interno
WO2008134525A1 (en) * 2007-04-26 2008-11-06 Auspex Pharmaeuticals, Inc. Deuterium labelled ketamine
EP2766339B1 (en) 2011-10-14 2021-06-09 The United States Of America, as represented by the Secretary, Department of Health & Human Services The use of (2r, 6r)-hydroxynorketamine and other stereoisomeric hydroxylated metabolites of (r,s)- ketamine in the treatment of depression and neuropathic pain
US20150259277A1 (en) * 2012-10-08 2015-09-17 James Wallace Sleigh Ketamine Derivatives

Also Published As

Publication number Publication date
US20150259277A1 (en) 2015-09-17
HK1212673A1 (zh) 2016-06-17
AU2013328280B2 (en) 2017-12-21
WO2014057414A1 (en) 2014-04-17
WO2014057414A9 (en) 2014-12-18
US20170190653A1 (en) 2017-07-06
JP2015535847A (ja) 2015-12-17
CA2922340A1 (en) 2014-04-17
IN2015DN03854A (es) 2015-10-02
JP2018127466A (ja) 2018-08-16
US10239825B2 (en) 2019-03-26
JP6309957B2 (ja) 2018-04-11
BR112015007647A2 (pt) 2017-07-04
AU2013328280A1 (en) 2015-05-14
US20190169113A1 (en) 2019-06-06
CN104837810B (zh) 2019-08-06
EA201590697A1 (ru) 2015-09-30
KR20150065873A (ko) 2015-06-15
EP2903963A1 (en) 2015-08-12
CN104837810A (zh) 2015-08-12
EP2903963A4 (en) 2016-05-25

Similar Documents

Publication Publication Date Title
MX2015004362A (es) Derivados de ketamina.
MX2014009757A (es) Derivados de isoindolina, composiciones farmaceuticas que los contienen y su uso en terapia.
PH12015501385A1 (en) Autotaxin inhibitors
PH12013501600A1 (en) Novel heterocyclic derivatives
TN2014000175A1 (en) Novel purine derivatives and their use in the treatment of disease
IN2014DN09434A (es)
PH12014501514A1 (en) New azetidine derivatives, pharmaceutical compositions and uses thereof
GB201118656D0 (en) New compounds
NZ608116A (en) Triazine-oxadiazoles
PH12015500274A1 (en) Alkylpyrimidine derivatives for the treatment of viral infections and further diseases
PH12015500713B1 (en) Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases
MX349004B (es) Nuevos compuestos.
MX2013011908A (es) Composiciones y usos terapeuticos de inhibidores de cinasa epsilon relacionados con cinasa i-kappa b (ikk) y cinasa 1 de union tank.
MX366899B (es) Nuevos compuestos.
IN2014MN00988A (es)
GB201106743D0 (en) Novel compounds
PH12013500007A1 (en) Piperidine derivatives and their use for the treatment of metabolic disorders
PH12014501967A1 (en) Benzodioxanes in combination with other actives for inhibiting leukotriene production
MX2015011614A (es) Derivados de pirrolidina, composiciones farmaceuticas que los contienen, y su uso en terapia.
MX2016004934A (es) Derivados de aminotetralina y aminoindano, composiciones farmaceuticas que los contienen, y su uso en terapia.
MX2015014905A (es) Compuestos de pirazino - [1,2-a] indol, su preparacion y su uso en medicamentos.
PH12015502420A1 (en) PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS
TN2013000327A1 (en) Novel heterocyclic derivatives
TN2013000089A1 (en) Triazine-oxadiazoles