[go: up one dir, main page]

MX2014014464A - Peptidos penetrantes de celulas y metodos para identificar peptidos penetrantes de celulas. - Google Patents

Peptidos penetrantes de celulas y metodos para identificar peptidos penetrantes de celulas.

Info

Publication number
MX2014014464A
MX2014014464A MX2014014464A MX2014014464A MX2014014464A MX 2014014464 A MX2014014464 A MX 2014014464A MX 2014014464 A MX2014014464 A MX 2014014464A MX 2014014464 A MX2014014464 A MX 2014014464A MX 2014014464 A MX2014014464 A MX 2014014464A
Authority
MX
Mexico
Prior art keywords
cell penetrating
penetrating peptides
methods
identifying
identifying cell
Prior art date
Application number
MX2014014464A
Other languages
English (en)
Inventor
Francesca Milletti
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014014464A publication Critical patent/MX2014014464A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)

Abstract

La presente invención se relaciona a péptidos penetrantes de células y métodos para identificar péptidos penetrantes de células en base a hidrofobicidad y polaridad.
MX2014014464A 2012-06-26 2013-06-24 Peptidos penetrantes de celulas y metodos para identificar peptidos penetrantes de celulas. MX2014014464A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261664210P 2012-06-26 2012-06-26
PCT/EP2013/063088 WO2014001229A2 (en) 2012-06-26 2013-06-24 Cell penetrating peptides & methods of identifying cell penetrating peptides

Publications (1)

Publication Number Publication Date
MX2014014464A true MX2014014464A (es) 2015-02-12

Family

ID=48672631

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014014464A MX2014014464A (es) 2012-06-26 2013-06-24 Peptidos penetrantes de celulas y metodos para identificar peptidos penetrantes de celulas.

Country Status (11)

Country Link
US (2) US20150183827A1 (es)
EP (1) EP2864348A2 (es)
JP (1) JP2015522264A (es)
KR (1) KR20150032265A (es)
CN (1) CN104428310A (es)
BR (1) BR112014027239A2 (es)
CA (1) CA2869283A1 (es)
HK (1) HK1205749A1 (es)
MX (1) MX2014014464A (es)
RU (1) RU2015102027A (es)
WO (1) WO2014001229A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10144767B2 (en) * 2016-08-18 2018-12-04 Board Of Regents Of The University Of Nebraska Anti-microbial peptides and coatings
WO2018156892A1 (en) 2017-02-23 2018-08-30 Adrx, Inc. Peptide inhibitors of transcription factor aggregation
CN110997693A (zh) 2017-06-07 2020-04-10 阿德克斯公司 τ聚集抑制剂
EP3668886A2 (en) 2017-08-18 2020-06-24 Adrx, Inc. Tau aggregation peptide inhibitors
CN108070025B (zh) * 2017-10-24 2019-11-19 中山大学附属口腔医院 一种细胞穿透肽和细胞穿透肽复合物及二者的应用
EP3556767A1 (en) * 2018-04-18 2019-10-23 Universidade De Santiago De Compostela Cell penetrating peptides
WO2019238686A1 (en) * 2018-06-13 2019-12-19 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. S.P.A. Peptides having inhibitory activity on muscarinic receptor m3
GB201812972D0 (en) 2018-08-09 2018-09-26 Univ Oxford Innovation Ltd Cell-penetrating peptides
GB201812980D0 (en) * 2018-08-09 2018-09-26 Univ Oxford Innovation Ltd Cell-penetrating peptides
KR20210064254A (ko) * 2018-09-26 2021-06-02 가부시키가이샤 가네카 세포막 투과성 펩티드
CN113453723A (zh) 2018-12-07 2021-09-28 牛津大学科技创新有限公司 接头
CN113661247A (zh) * 2019-02-19 2021-11-16 欧洲分子生物学实验室 细胞穿透转座酶

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030134328A1 (en) * 2001-09-06 2003-07-17 Basham Beth E. Mammalian genes; related reagents
SE0201863D0 (en) 2002-06-18 2002-06-18 Cepep Ab Cell penetrating peptides
US20090023895A1 (en) * 2006-02-07 2009-01-22 Nec Corporation Hla-binding peptide, precursor thereof, and dna fragment and recombinant vector coding for said hla-binding peptide
WO2009030254A1 (en) * 2007-09-04 2009-03-12 Curevac Gmbh Complexes of rna and cationic peptides for transfection and for immunostimulation
EP2080519A1 (en) * 2008-01-15 2009-07-22 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Peptides having binding affinity to an antibody which recognizes an epitope on an alpha1 loop 2 or beta 2 loop 1 of an adrenoreceptor
JP2010085108A (ja) * 2008-09-29 2010-04-15 Nano Factory:Kk 生体光イメージング用プローブ
RU2556800C2 (ru) * 2010-06-14 2015-07-20 Ф.Хоффманн-Ля Рош Аг Пептиды, проникающие в клетки, и их применения

Also Published As

Publication number Publication date
EP2864348A2 (en) 2015-04-29
WO2014001229A2 (en) 2014-01-03
JP2015522264A (ja) 2015-08-06
BR112014027239A2 (pt) 2017-07-18
KR20150032265A (ko) 2015-03-25
US20180094030A1 (en) 2018-04-05
WO2014001229A3 (en) 2014-03-06
HK1205749A1 (en) 2015-12-24
US20150183827A1 (en) 2015-07-02
CA2869283A1 (en) 2014-01-03
RU2015102027A (ru) 2016-08-10
CN104428310A (zh) 2015-03-18

Similar Documents

Publication Publication Date Title
MX2014014464A (es) Peptidos penetrantes de celulas y metodos para identificar peptidos penetrantes de celulas.
MX2022000026A (es) Anticuerpos para tau.
PH12014501427B1 (en) Anti-phf-tau antibodies and their uses
PH12015501437A1 (en) Zinc amino acid halide mouthwashes
MX2015006324A (es) Metodos para la fabricacion de polipeptidos proteoliticamente procesados.
MX2013015311A (es) Polipeptidos de enlace de pcsk9 y metodos de uso.
PH12014502132A1 (en) Anti-lgr5 antibodies and immunoconjugates
IN2015DN00127A (es)
PH12015502565A1 (en) Anti-transferrin receptor antibodies and methods of use
PH12014501605A1 (en) Anti-lrp5 antibodies and methods of use
MX2013011479A (es) Anticuerpos anti-fgfr4 y metodos de uso.
MX2014002053A (es) Anticuerpos anti -mcsp y metodos de uso.
IN2014DN08721A (es)
UY34721A (es) Anticuerpos anti-hla-b*27 y usos de éstos.
MX336001B (es) Anticuerpos anti-axl y metodos de uso.
PH12014500841B1 (en) ANTI-HtrA1 ANTIBODIES AND METHODS OF USE
MX340555B (es) Anticuerpos contra il-18r1 y usos de los mismos.
MX2014014376A (es) Anticuerpos de anti-biotina y metodos de uso.
MX336323B (es) Anticuerpos de anti-poliubiquitina y metodos de uso.
GB201222833D0 (en) Detection of membrane proteins
HUP1200239A2 (en) Quantitative biomarkers of the erythrocyte membrane
MX357675B (es) Anticuerpos anti-jagged y métodos de uso.
MX353951B (es) Anticuerpos de anti-teofilina y metodos de uso.
UA117567C2 (uk) Композиція, яка стимулює лактацію, на основі фосфатидилсерину
MY172819A (en) Zinc amino acid halide mouthwashes