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MX2014001598A - 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas. - Google Patents

3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas.

Info

Publication number
MX2014001598A
MX2014001598A MX2014001598A MX2014001598A MX2014001598A MX 2014001598 A MX2014001598 A MX 2014001598A MX 2014001598 A MX2014001598 A MX 2014001598A MX 2014001598 A MX2014001598 A MX 2014001598A MX 2014001598 A MX2014001598 A MX 2014001598A
Authority
MX
Mexico
Prior art keywords
naphthyridinones
dihydro
antibacterial
compounds
homopiperidinyl substituted
Prior art date
Application number
MX2014001598A
Other languages
English (en)
Other versions
MX360856B (es
Inventor
Jerôme Emile Georges Guillemont
Anil Koul
David Francis Alain Lançois
Magali Madeleine Simone Motte
Wendy Mia Albert Balemans
Original Assignee
Janssen R & D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland
Publication of MX2014001598A publication Critical patent/MX2014001598A/es
Publication of MX360856B publication Critical patent/MX360856B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I) novedosos que inhiben la actividad de la enzima FabI, los cuales son por lo tanto útiles en el tratamiento de infecciones bacterianas; también se refiere a composiciones farmacéuticas que comprenden estos compuestos y a procesos químicos para la preparación de estos compuestos. (ver Fórmula).
MX2014001598A 2011-08-10 2012-08-10 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas. MX360856B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11177115 2011-08-10
PCT/EP2012/065729 WO2013021051A1 (en) 2011-08-10 2012-08-10 Antibacterial homopiperidinyl substituted 3,4 dihydro 1h [1,8]naphthyridinones

Publications (2)

Publication Number Publication Date
MX2014001598A true MX2014001598A (es) 2014-04-25
MX360856B MX360856B (es) 2018-11-20

Family

ID=46639542

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001598A MX360856B (es) 2011-08-10 2012-08-10 3,4-dihidro-1h-[1,8]naftiridinosas sustituidas con homopiperidinilo antibacterianas.

Country Status (13)

Country Link
US (1) US9394295B2 (es)
EP (1) EP2742044B1 (es)
JP (2) JP6521631B2 (es)
KR (1) KR101996866B1 (es)
CN (2) CN108003155A (es)
AU (1) AU2012293618B2 (es)
BR (1) BR112014003146B1 (es)
CA (1) CA2842526C (es)
EA (1) EA038317B1 (es)
ES (1) ES2776145T3 (es)
HK (2) HK1200445A1 (es)
MX (1) MX360856B (es)
WO (1) WO2013021051A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3611B1 (ar) 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
CA2842526C (en) * 2011-08-10 2019-07-23 Janssen R&D Ireland Antibacterial homopiperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones
US9062002B2 (en) 2011-12-02 2015-06-23 Aurigene Discovery Technologies Limited Substituted pyridine derivatives as FabI inhibitors
US9062075B2 (en) 2011-12-02 2015-06-23 Aurigene Discovery Technologies Limited Tetrahydropyridine derivatives as FabI inhibitors
WO2014072930A2 (en) * 2012-11-09 2014-05-15 Aurigene Discovery Technologies Limited Fused pyridine derivatives as antibacterial agents
EP3004099B1 (en) 2013-06-04 2023-04-19 Aurigene Oncology Limited Tetrahydropyridine derivatives as fabi inhibitors
WO2015071780A1 (en) * 2013-11-12 2015-05-21 Aurigene Discovery Technologies Limited Alkylidine substituted heterocyclyl derivatives as anti-bacterial agents
WO2020191151A1 (en) * 2019-03-19 2020-09-24 Oncovalent Therapeutics Inc. Sumo inhibitor compounds and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215123A (en) 1979-05-07 1980-07-29 American Home Products Corporation Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
CO5251397A1 (es) 1999-10-08 2003-02-28 Smithkline Beecham Corp Inhibidores de fab i
EP1225895B1 (en) 1999-10-08 2005-05-04 Affinium Pharmaceuticals, Inc. Fab i inhibitors
AU773218B2 (en) 1999-10-08 2004-05-20 Debiopharm International Sa Fab I inhibitors
EP1560584B1 (en) 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab i inhibitors
US8450307B2 (en) * 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
US7973060B2 (en) 2005-10-13 2011-07-05 Crystalgenomics, Inc. Fab I inhibitor and process for preparing same
WO2008009122A1 (en) * 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
WO2011061214A1 (en) * 2009-11-18 2011-05-26 Fab Pharma Sas Novel heterocyclic acrylamides and their use as pharmaceuticals
CA2842526C (en) * 2011-08-10 2019-07-23 Janssen R&D Ireland Antibacterial homopiperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones

Also Published As

Publication number Publication date
CA2842526C (en) 2019-07-23
US20140171418A1 (en) 2014-06-19
HK1254403A1 (zh) 2019-07-19
BR112014003146A2 (pt) 2021-01-26
CN104039782A (zh) 2014-09-10
EA201490436A1 (ru) 2014-07-30
AU2012293618B2 (en) 2017-04-20
JP6521631B2 (ja) 2019-05-29
EA038317B1 (ru) 2021-08-09
CA2842526A1 (en) 2013-02-14
JP2017222646A (ja) 2017-12-21
ES2776145T3 (es) 2020-07-29
JP2014531403A (ja) 2014-11-27
HK1200445A1 (en) 2015-08-07
AU2012293618A1 (en) 2014-02-06
WO2013021051A1 (en) 2013-02-14
KR20140072025A (ko) 2014-06-12
BR112014003146B1 (pt) 2022-03-15
KR101996866B1 (ko) 2019-07-05
EP2742044B1 (en) 2019-12-04
MX360856B (es) 2018-11-20
US9394295B2 (en) 2016-07-19
CN108003155A (zh) 2018-05-08
EP2742044A1 (en) 2014-06-18

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Owner name: JANSSEN SCIENCES IRELAND UC

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