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MX2013012771A - Proceso para la preparacion de inhibidores del virus de la hepatitis c. - Google Patents

Proceso para la preparacion de inhibidores del virus de la hepatitis c.

Info

Publication number
MX2013012771A
MX2013012771A MX2013012771A MX2013012771A MX2013012771A MX 2013012771 A MX2013012771 A MX 2013012771A MX 2013012771 A MX2013012771 A MX 2013012771A MX 2013012771 A MX2013012771 A MX 2013012771A MX 2013012771 A MX2013012771 A MX 2013012771A
Authority
MX
Mexico
Prior art keywords
hepatitis
virus
processes
compounds
inhibitors
Prior art date
Application number
MX2013012771A
Other languages
English (en)
Inventor
Frank Chen
Marc Poirier
Ji Xie
George Wu
Joseph Lamberson
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2013012771A publication Critical patent/MX2013012771A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a procesos sintéticos útiles en la preparación de compuestos de Fórmula I que son útiles como inhibidores de la proteasa NS3 del virus de la hepatitis C (VHC) y tienen aplicación en el tratamiento de afecciones causadas por el VHC; en particular, la presente invención se refiere a procesos de oxidación novedosos útiles para preparar compuestos de Fórmula I: (Ver Formula) y compuestos relacionados, incluyendo sales, hidratos y solvatos farmacéuticamente aceptables de los mismos, e incluyendo estereoisómeros de los mismos.
MX2013012771A 2011-05-04 2012-05-02 Proceso para la preparacion de inhibidores del virus de la hepatitis c. MX2013012771A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161482592P 2011-05-04 2011-05-04
PCT/US2012/036112 WO2012151271A1 (en) 2011-05-04 2012-05-02 Processes for preparing inhibitors of the hepatitis c virus

Publications (1)

Publication Number Publication Date
MX2013012771A true MX2013012771A (es) 2013-11-21

Family

ID=47108028

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013012771A MX2013012771A (es) 2011-05-04 2012-05-02 Proceso para la preparacion de inhibidores del virus de la hepatitis c.
MX2013012773A MX2013012773A (es) 2011-05-04 2012-05-02 Sustancias farmacologicas, composiciones farmaceuticas y metodos para la preparacion de las mismas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2013012773A MX2013012773A (es) 2011-05-04 2012-05-02 Sustancias farmacologicas, composiciones farmaceuticas y metodos para la preparacion de las mismas.

Country Status (17)

Country Link
US (2) US20140058116A1 (es)
EP (2) EP2704576A4 (es)
JP (2) JP2014515764A (es)
KR (2) KR20140022855A (es)
CN (2) CN103476260A (es)
AR (1) AR086259A1 (es)
AU (2) AU2012250811A1 (es)
BR (2) BR112013027642A2 (es)
CA (2) CA2832869A1 (es)
CO (1) CO6801768A2 (es)
IL (1) IL228601A0 (es)
MX (2) MX2013012771A (es)
RU (2) RU2013153533A (es)
SG (1) SG194711A1 (es)
TW (1) TW201247668A (es)
WO (2) WO2012151283A1 (es)
ZA (1) ZA201308011B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8828930B2 (en) 2009-07-30 2014-09-09 Merck Sharp & Dohme Corp. Hepatitis C virus NS3 protease inhibitors
PL3010891T3 (pl) * 2013-06-19 2019-11-29 Aicuris Anti Infective Cures Gmbh Amorficzny letermowir i jego stałe preparaty farmaceutyczne do podawania doustnego
HUE071505T2 (hu) * 2017-03-07 2025-09-28 Orion Corp Kristályos gyógyszerkészítmény gyártása
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR044694A1 (es) * 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
AR056805A1 (es) * 2005-11-14 2007-10-24 Schering Corp Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados
US8420122B2 (en) * 2006-04-28 2013-04-16 Merck Sharp & Dohme Corp. Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
CN101495095B (zh) * 2006-04-28 2013-05-29 默沙东公司 通过受控的沉淀来沉淀和分离6,6-二甲基-3-氮杂-双环[3.1.0]己烷-酰胺化合物的方法和含有其的药学制剂
ES2439246T3 (es) * 2006-12-20 2014-01-22 Merck Sharp & Dohme Corp. Procedimiento de preparación de (1R,2S,5S)-N-[(1S)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil]-3-[(2S)-2-[[[(1,1-dimetiletil)amino]carbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3.1.0]hexan-2-carboxamida
CA2677170C (en) * 2007-02-01 2017-04-18 Tibotec Pharmaceuticals Ltd. Polymorphic forms of a macrocyclic inhibitor of hcv
JP4803074B2 (ja) * 2007-03-06 2011-10-26 日産化学工業株式会社 アルコール酸化触媒およびその合成方法
ES2369321T3 (es) * 2007-09-14 2011-11-29 Schering Corporation Procedimiento para el tratamiento de pacientes con hepatitis c.
DE102009000662A1 (de) * 2009-02-06 2010-08-12 Evonik Degussa Gmbh Verfahren zur Herstellung von Aldehyden und Ketonen aus primären und sekundären Alkoholen

Also Published As

Publication number Publication date
BR112013027652A2 (pt) 2016-07-26
AU2012250799A1 (en) 2013-10-10
IL228601A0 (en) 2013-12-31
US20140044759A1 (en) 2014-02-13
RU2013153533A (ru) 2015-06-10
EP2704576A4 (en) 2014-12-10
KR20140030169A (ko) 2014-03-11
CA2833887A1 (en) 2012-11-08
BR112013027642A2 (pt) 2016-07-26
ZA201308011B (en) 2015-05-27
CA2832869A1 (en) 2012-11-08
JP2014515764A (ja) 2014-07-03
EP2704576A1 (en) 2014-03-12
KR20140022855A (ko) 2014-02-25
EP2704570A1 (en) 2014-03-12
JP2014513127A (ja) 2014-05-29
AU2012250811A1 (en) 2013-12-19
WO2012151271A1 (en) 2012-11-08
CO6801768A2 (es) 2013-11-29
NZ617300A (en) 2015-06-26
RU2013153588A (ru) 2015-06-10
MX2013012773A (es) 2013-11-21
EP2704570A4 (en) 2015-02-18
AR086259A1 (es) 2013-12-04
CN103476260A (zh) 2013-12-25
TW201247668A (en) 2012-12-01
CN103501608A (zh) 2014-01-08
SG194711A1 (en) 2013-12-30
WO2012151283A1 (en) 2012-11-08
US20140058116A1 (en) 2014-02-27

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