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MX2013009253A - Formulaciones multiparticuladas de l-mentol y metodos relacionados. - Google Patents

Formulaciones multiparticuladas de l-mentol y metodos relacionados.

Info

Publication number
MX2013009253A
MX2013009253A MX2013009253A MX2013009253A MX2013009253A MX 2013009253 A MX2013009253 A MX 2013009253A MX 2013009253 A MX2013009253 A MX 2013009253A MX 2013009253 A MX2013009253 A MX 2013009253A MX 2013009253 A MX2013009253 A MX 2013009253A
Authority
MX
Mexico
Prior art keywords
menthol
multiparticulate
core
release
related methods
Prior art date
Application number
MX2013009253A
Other languages
English (en)
Inventor
Syed M Shah
Daniel Hassan
Sarah Hassan
Original Assignee
Zx Pharma Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zx Pharma Llc filed Critical Zx Pharma Llc
Publication of MX2013009253A publication Critical patent/MX2013009253A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se descrien las formulaciones multiparticuladas recubiertas entéricas que usan el L-mentol como un ingrediente activo. En una modalidad, la formulación multiparticulada comprende una pluralidad de elementos particulados que tienen una liberación reducida bajo condiciones gástricas y una liberación elevada a pH neutro. Los elementos particulados comprenden un núcleo que comprende el L-mentol como un ingrediente activo. El L-mentol se suministra al núcleo como un material de L-mentol por lo menos 80% puro. Un recubrimiento entérico está sobre el núcleo. El recubrimiento entérico es eficaz en liberar por lo menos aproximadamente 80% del L-mentol en un periodo de aproximadamente dos horas después de colocarse en un ambiente de pH sustancialmente neutro. Otros aspectos de la invención incluyen los métodos de fabricación y los métodos para usar las formulaciones multiparticuladas.
MX2013009253A 2011-02-11 2012-02-07 Formulaciones multiparticuladas de l-mentol y metodos relacionados. MX2013009253A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161441716P 2011-02-11 2011-02-11
US201161486523P 2011-05-16 2011-05-16
PCT/US2012/024110 WO2012109216A1 (en) 2011-02-11 2012-02-07 Multiparticulate l-menthol formulations and related methods

Publications (1)

Publication Number Publication Date
MX2013009253A true MX2013009253A (es) 2013-12-16

Family

ID=46637058

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013009253A MX2013009253A (es) 2011-02-11 2012-02-07 Formulaciones multiparticuladas de l-mentol y metodos relacionados.

Country Status (15)

Country Link
US (3) US8568776B2 (es)
EP (1) EP2672981B1 (es)
JP (1) JP6025755B2 (es)
KR (1) KR101809305B1 (es)
CN (1) CN103442727B (es)
AU (1) AU2012214553B2 (es)
BR (1) BR112013020404B1 (es)
CA (1) CA2826889C (es)
ES (1) ES2673286T3 (es)
MX (1) MX2013009253A (es)
PL (1) PL2672981T3 (es)
PT (1) PT2672981T (es)
RU (1) RU2590979C2 (es)
TR (1) TR201808978T4 (es)
WO (1) WO2012109216A1 (es)

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US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
ES2673286T3 (es) 2011-02-11 2018-06-21 Zx Pharma, Llc Formulaciones multiparticuladas de L-mentol y métodos relacionados
SMT201900021T1 (it) * 2013-04-23 2019-02-28 Zx Pharma Llc Composizione gastroresistente a base di multiparticolato con sottorivestimento proteinaceo
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CN103800307A (zh) * 2013-12-20 2014-05-21 中国人民解放军第三军医大学第三附属医院 一种降血压用药物组合物及制备方法
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CA2988082C (en) * 2015-06-01 2020-09-29 Symbiomix Therapeutics, Llc Novel nitroimidazole formulations and uses thereof
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US20160000728A1 (en) 2016-01-07
RU2590979C2 (ru) 2016-07-10
BR112013020404A2 (pt) 2017-07-18
KR101809305B1 (ko) 2017-12-14
CA2826889A1 (en) 2012-08-16
US9132095B2 (en) 2015-09-15
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US11779547B2 (en) 2023-10-10
PT2672981T (pt) 2018-06-21
AU2012214553A1 (en) 2013-08-29
CA2826889C (en) 2016-12-20
EP2672981A1 (en) 2013-12-18
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