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MX2013007699A - Solucion de eluyente. - Google Patents

Solucion de eluyente.

Info

Publication number
MX2013007699A
MX2013007699A MX2013007699A MX2013007699A MX2013007699A MX 2013007699 A MX2013007699 A MX 2013007699A MX 2013007699 A MX2013007699 A MX 2013007699A MX 2013007699 A MX2013007699 A MX 2013007699A MX 2013007699 A MX2013007699 A MX 2013007699A
Authority
MX
Mexico
Prior art keywords
radiofluorination
preparation
present
prepared
eluent solution
Prior art date
Application number
MX2013007699A
Other languages
English (en)
Other versions
MX363538B (es
Inventor
Ole Kristian Hjelstuen
Torild Wickstrom
Anders Svadberg
Dag M Evje
Liane Ochsenfeld
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of MX2013007699A publication Critical patent/MX2013007699A/es
Publication of MX363538B publication Critical patent/MX363538B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B9/00—General methods of preparing halides
    • C01B9/08—Fluorides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención proporciona un novedoso método para la preparación de 18F-fluoruro (18F) para uso en reacciones de radiofluoración. El método de la invención encuentra uso especialmente en la preparación de trazadores de tomografía de emisión de positrones (PET) 18F-etiquetados. El método de la invención es particularmente ventajoso sonde las soluciones a granel son preparadas y almacenadas envíales prellenados en lugar de ser recién preparadas en el día de síntesis. La presente invención también proporciona una reacción de radiofluoración, la cual comprende el método de la invención, así como un casete para uso para realizar el método de la invención y/o el método de radiofluoración de la invención en un aparato de radiosintesis automatizado.
MX2013007699A 2010-12-29 2011-12-21 Solucion de eluyente. MX363538B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061427839P 2010-12-29 2010-12-29
PCT/EP2011/073670 WO2012089594A1 (en) 2010-12-29 2011-12-21 Eluent solution

Publications (2)

Publication Number Publication Date
MX2013007699A true MX2013007699A (es) 2013-08-15
MX363538B MX363538B (es) 2019-03-27

Family

ID=45495902

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007699A MX363538B (es) 2010-12-29 2011-12-21 Solucion de eluyente.

Country Status (16)

Country Link
US (3) US11504430B2 (es)
EP (2) EP2658831B1 (es)
JP (1) JP6018581B2 (es)
KR (3) KR20130132892A (es)
CN (2) CN108218650A (es)
AU (1) AU2011351550B2 (es)
BR (2) BR112013015396B1 (es)
CA (1) CA2823063C (es)
DK (3) DK2658831T3 (es)
ES (2) ES2621950T3 (es)
MX (1) MX363538B (es)
PL (2) PL2658831T3 (es)
PT (2) PT3766522T (es)
RU (1) RU2608932C2 (es)
SG (1) SG10201805198TA (es)
WO (1) WO2012089594A1 (es)

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CN108218650A (zh) * 2010-12-29 2018-06-29 通用电气健康护理有限公司 洗脱溶液
BR112014009013A2 (pt) * 2011-10-19 2017-05-02 Piramal Imaging Sa método melhorado para a produção de ligandos aß rotulados por f-18
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
GB201221266D0 (en) 2012-11-27 2013-01-09 Ge Healthcare Ltd Aldehyde compositions
GB201305687D0 (en) * 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process
EP3068747B1 (en) 2013-11-13 2024-10-30 GE Healthcare Limited Dual run cassette for the synthesis of 18f-labelled compounds
US9988336B2 (en) * 2014-03-18 2018-06-05 Mayo Foundation For Medical Education And Research Gaseous F-18 technologies
NL2014828B1 (en) 2015-05-20 2017-01-31 Out And Out Chemistry S P R L Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method.
JP6827709B2 (ja) * 2016-04-25 2021-02-10 日本メジフィジックス株式会社 ２−［１８ｆ］フルオロ−２−デオキシ−ｄ−グルコースの製造方法
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
JP7148121B2 (ja) * 2018-08-31 2022-10-05 国立大学法人北海道大学 放射性核種１８ｆの精製方法
GB202005282D0 (en) * 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations
JP7127164B2 (ja) * 2021-01-19 2022-08-29 日本メジフィジックス株式会社 ２－［１８ｆ］フルオロ－２－デオキシ－ｄ－グルコースの製造方法
CN113372399A (zh) * 2021-06-04 2021-09-10 江苏华益科技有限公司 一种氟[18f]脱氧葡糖注射液的合成方法
CN119591463B (zh) * 2024-11-27 2025-12-09 遵义医科大学 一种 [18f] 三氟甲基末端烯烃的放射性标记方法

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Also Published As

Publication number Publication date
BR112014015042B1 (pt) 2021-10-26
US20190192660A1 (en) 2019-06-27
EP2658831B1 (en) 2017-02-15
US20130324715A1 (en) 2013-12-05
RU2608932C2 (ru) 2017-01-26
KR20190119673A (ko) 2019-10-22
DK3766522T3 (da) 2022-06-13
DK2658831T3 (en) 2017-04-24
RU2013126979A (ru) 2015-03-20
BR112013015396A2 (pt) 2016-09-20
PL3766522T3 (pl) 2022-07-04
KR102218263B1 (ko) 2021-02-22
WO2012089594A1 (en) 2012-07-05
EP2658831A1 (en) 2013-11-06
CN108218650A (zh) 2018-06-29
AU2011351550B2 (en) 2017-02-02
KR102137348B1 (ko) 2020-07-23
EP3766522B1 (en) 2022-03-23
JP2014508731A (ja) 2014-04-10
KR20130132892A (ko) 2013-12-05
DK2793954T3 (da) 2021-01-04
BR112013015396B1 (pt) 2021-11-03
US11504430B2 (en) 2022-11-22
BR112014015042A2 (pt) 2017-06-13
PT3766522T (pt) 2022-06-14
SG10201805198TA (en) 2018-07-30
CA2823063A1 (en) 2012-07-05
CA2823063C (en) 2020-08-11
JP6018581B2 (ja) 2016-11-02
US20230068052A1 (en) 2023-03-02
AU2011351550A1 (en) 2013-07-25
MX363538B (es) 2019-03-27
ES2917875T3 (es) 2022-07-12
BR112014015042A8 (pt) 2017-07-04
KR20190008994A (ko) 2019-01-25
PL2658831T3 (pl) 2017-07-31
CN103270004A (zh) 2013-08-28
PT2793954T (pt) 2021-01-06
EP3766522A1 (en) 2021-01-20
ES2621950T3 (es) 2017-07-05

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