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MX2013007661A - Derivados de fenil-isoxazol y procedimiento para la preparacion de los mismos. - Google Patents

Derivados de fenil-isoxazol y procedimiento para la preparacion de los mismos.

Info

Publication number
MX2013007661A
MX2013007661A MX2013007661A MX2013007661A MX2013007661A MX 2013007661 A MX2013007661 A MX 2013007661A MX 2013007661 A MX2013007661 A MX 2013007661A MX 2013007661 A MX2013007661 A MX 2013007661A MX 2013007661 A MX2013007661 A MX 2013007661A
Authority
MX
Mexico
Prior art keywords
phenyl
preparation process
isoxazol
derivatives
compound
Prior art date
Application number
MX2013007661A
Other languages
English (en)
Other versions
MX340098B (es
Inventor
Dong Yeon Kim
Dae Jin Cho
Gong Yeal Lee
Hong Youb Kim
Seok Hun Woo
Hae Un Lee
Kim Sung Moo
Chong Am Ahn
Original Assignee
Il Yang Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46514985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013007661(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Il Yang Pharm Co Ltd filed Critical Il Yang Pharm Co Ltd
Publication of MX2013007661A publication Critical patent/MX2013007661A/es
Publication of MX340098B publication Critical patent/MX340098B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describe un compuesto derivado de fenil-isoxazol representado por la Fórmula 1 que se describe a continuación, que es útil como material de tratamiento para infecciones virales, especialmente la infección causada por un virus de la influenza, o su derivado farmacéuticamente aceptable, un método de preparación del mismo y una composición farmacéutica para el tratamiento de enfermedades, incluyendo el compuesto como principio activo:Fórmula 1 (Ver Formula) donde en la Fórmula citada anteriormente, R1, R2, R3, R4 y R8 son iguales a los que se define en la especificación.
MX2013007661A 2011-04-19 2012-03-30 Derivados de fenil-isoxazol y procedimiento para la preparacion de los mismos. MX340098B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110036172A KR101369584B1 (ko) 2011-04-19 2011-04-19 페닐-이속사졸 유도체 및 그의 제조방법
PCT/KR2012/002362 WO2012144752A1 (en) 2011-04-19 2012-03-30 Phenyl-isoxazol derivatives and preparation process thereof

Publications (2)

Publication Number Publication Date
MX2013007661A true MX2013007661A (es) 2013-08-12
MX340098B MX340098B (es) 2016-06-27

Family

ID=46514985

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007661A MX340098B (es) 2011-04-19 2012-03-30 Derivados de fenil-isoxazol y procedimiento para la preparacion de los mismos.

Country Status (21)

Country Link
US (1) US9132126B2 (es)
EP (1) EP2699566B1 (es)
JP (1) JP5833143B2 (es)
KR (1) KR101369584B1 (es)
CN (1) CN103313982B (es)
AR (1) AR086029A1 (es)
AU (1) AU2012246914B2 (es)
CA (1) CA2824757A1 (es)
CL (1) CL2013001910A1 (es)
CO (1) CO6771432A2 (es)
EA (1) EA022336B1 (es)
IL (1) IL227711A0 (es)
MX (1) MX340098B (es)
PE (1) PE20140629A1 (es)
PH (1) PH12013501883A1 (es)
SA (1) SA112330457B1 (es)
SG (1) SG192134A1 (es)
TW (1) TWI434836B (es)
UY (1) UY34023A (es)
WO (1) WO2012144752A1 (es)
ZA (1) ZA201305277B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020506192A (ja) 2017-02-02 2020-02-27 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． インフルエンザウイルスを阻害するためのピペラジン誘導体
WO2018141854A1 (en) 2017-02-02 2018-08-09 Janssen Vaccines & Prevention B.V. Piperazine derivatives for influenza virus inhibition
CA3052503A1 (en) * 2017-02-08 2018-08-16 Biotron Limited Methods of treating influenza
TWI765323B (zh) * 2019-08-22 2022-05-21 大陸商四川海思科製藥有限公司 抗流感病毒化合物及其製備方法和用途
CN111704587B (zh) * 2020-06-29 2023-04-07 遵义医科大学 一种三氟甲基化1,3-噁嗪类化合物的合成方法
CN114349746A (zh) * 2020-11-19 2022-04-15 中国医学科学院医药生物技术研究所 一种含有4-氟苯基片段的吡啶类化合物及其制备方法和应用、药物组合物
WO2022166767A1 (zh) 2021-02-04 2022-08-11 四川海思科制药有限公司 Ha抑制剂化合物的盐及晶型

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EP1578721A2 (en) 2001-10-12 2005-09-28 Onconova Therapeutics, Inc. Processes for the preparation of substituted isoxazoles and 2-isoxazolines
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Also Published As

Publication number Publication date
US9132126B2 (en) 2015-09-15
SG192134A1 (en) 2013-08-30
TW201309658A (zh) 2013-03-01
CA2824757A1 (en) 2012-10-26
TWI434836B (zh) 2014-04-21
AU2012246914B2 (en) 2015-09-24
JP2014503601A (ja) 2014-02-13
MX340098B (es) 2016-06-27
NZ613314A (en) 2015-09-25
AU2012246914A1 (en) 2013-08-15
PE20140629A1 (es) 2014-05-22
HK1188998A1 (zh) 2014-05-23
WO2012144752A1 (en) 2012-10-26
EA201300805A1 (ru) 2013-11-29
CL2013001910A1 (es) 2014-04-21
CO6771432A2 (es) 2013-10-15
EP2699566A4 (en) 2014-09-03
JP5833143B2 (ja) 2015-12-16
EP2699566B1 (en) 2017-02-22
UY34023A (es) 2012-06-29
CN103313982B (zh) 2016-02-03
KR101369584B1 (ko) 2014-03-06
US20140031364A1 (en) 2014-01-30
PH12013501883A1 (en) 2019-06-03
EP2699566A1 (en) 2014-02-26
CN103313982A (zh) 2013-09-18
KR20120118665A (ko) 2012-10-29
AR086029A1 (es) 2013-11-13
EA022336B1 (ru) 2015-12-30
ZA201305277B (en) 2014-09-25
SA112330457B1 (ar) 2015-08-19
IL227711A0 (en) 2013-09-30

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