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MX2013002956A - Arilsulfonamidas para el tratamiento de enfermedades del sistema nervioso central. - Google Patents

Arilsulfonamidas para el tratamiento de enfermedades del sistema nervioso central.

Info

Publication number
MX2013002956A
MX2013002956A MX2013002956A MX2013002956A MX2013002956A MX 2013002956 A MX2013002956 A MX 2013002956A MX 2013002956 A MX2013002956 A MX 2013002956A MX 2013002956 A MX2013002956 A MX 2013002956A MX 2013002956 A MX2013002956 A MX 2013002956A
Authority
MX
Mexico
Prior art keywords
treatment
arylosulfonamides
cns diseases
disorders
prevention
Prior art date
Application number
MX2013002956A
Other languages
English (en)
Inventor
Marcin Kolaczkowski
Piotr Kowalski
Jolanta Jaskowska
Monika Marcinkowski
Kayarzyna Mitka
Adam Bucki
Anna Wesolowska
Maciej Pawlowski
Original Assignee
Adamed Sp Zoo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adamed Sp Zoo filed Critical Adamed Sp Zoo
Publication of MX2013002956A publication Critical patent/MX2013002956A/es

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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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Abstract

Derivados de arilsulfonamida de la fórmula (I) y sales farmacéuticamente aceptables de los mismos; los compuestos pueden ser útiles para el tratamiento y/o prevención de trastornos del sistema nervioso central.
MX2013002956A 2010-09-17 2011-09-16 Arilsulfonamidas para el tratamiento de enfermedades del sistema nervioso central. MX2013002956A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL39243610A PL392436A1 (pl) 2010-09-17 2010-09-17 Pochodne arylosulfonamidów do leczenia chorób odśrodkowego układu nerwowego
PCT/EP2011/066054 WO2012035123A1 (en) 2010-09-17 2011-09-16 Arylosulfonamides for the treatment of cns diseases

Publications (1)

Publication Number Publication Date
MX2013002956A true MX2013002956A (es) 2013-05-09

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MX2013002956A MX2013002956A (es) 2010-09-17 2011-09-16 Arilsulfonamidas para el tratamiento de enfermedades del sistema nervioso central.

Country Status (15)

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US (2) US8822517B2 (es)
EP (1) EP2616440A1 (es)
JP (1) JP5899218B2 (es)
KR (1) KR20130143569A (es)
CN (2) CN103108864A (es)
AU (1) AU2011303807B2 (es)
BR (1) BR112013006313A2 (es)
CA (1) CA2808246A1 (es)
EA (1) EA022776B1 (es)
MX (1) MX2013002956A (es)
NZ (1) NZ607031A (es)
PL (1) PL392436A1 (es)
UA (1) UA109793C2 (es)
WO (1) WO2012035123A1 (es)
ZA (2) ZA201302390B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105085436B (zh) 2014-04-19 2019-08-16 广东东阳光药业有限公司 磺酰胺类衍生物及其在药物上的应用
CN106749219A (zh) * 2015-11-20 2017-05-31 江苏恩华药业股份有限公司 一种内酰胺类衍生物及其应用
CN107602446B (zh) * 2016-07-12 2020-04-07 中国科学院上海药物研究所 1,4-双取代-1,2,3,6-四氢吡啶类化合物、其制备方法、药物组合物及其应用
KR20220120625A (ko) * 2019-12-24 2022-08-30 스미토모 파마 가부시키가이샤 지방족 산 아미드 유도체
KR102447231B1 (ko) * 2020-05-29 2022-09-27 재단법인 대구경북첨단의료산업진흥재단 설폰아미드 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물
CN116157124A (zh) * 2020-05-29 2023-05-23 大邱庆北尖端医疗产业振兴财团 磺胺衍生物和含其作为活性成分的用于预防或治疗精神疾病的药物组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2258843B1 (es) * 1974-01-30 1977-09-09 Roussel Uclaf
ATE44528T1 (de) 1984-12-21 1989-07-15 Duphar Int Res Arzneimittel mit antipsychotischer wirkung.
JP2556722B2 (ja) 1988-02-18 1996-11-20 興和株式会社 新規なスルホンアミド化合物
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
TWI242011B (en) * 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
GB9825413D0 (en) * 1998-11-19 1999-01-13 Lilly Co Eli Pharmaceutical compounds
GB9906624D0 (en) * 1999-03-23 1999-05-19 Smithkline Beecham Plc Novel compounds
EP1578740B1 (en) * 2002-12-27 2007-03-21 H. Lundbeck A/S 1,2,4-triaminobenzene derivatives useful for treating disorders of the central nervous system
US7153858B2 (en) 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
CA2637531A1 (en) * 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-ht6 receptor affinity

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US20140336200A1 (en) 2014-11-13
BR112013006313A2 (pt) 2016-06-07
PL392436A1 (pl) 2012-03-26
US20130172365A1 (en) 2013-07-04
NZ607031A (en) 2014-06-27
CN104529999A (zh) 2015-04-22
CA2808246A1 (en) 2012-03-22
EP2616440A1 (en) 2013-07-24
EA022776B1 (ru) 2016-02-29
JP5899218B2 (ja) 2016-04-06
US9120767B2 (en) 2015-09-01
KR20130143569A (ko) 2013-12-31
US8822517B2 (en) 2014-09-02
ZA201305970B (en) 2014-04-30
AU2011303807A1 (en) 2013-02-28
UA109793C2 (uk) 2015-10-12
JP2013540738A (ja) 2013-11-07
EA201390398A1 (ru) 2013-07-30
CN103108864A (zh) 2013-05-15
WO2012035123A1 (en) 2012-03-22
ZA201302390B (en) 2013-12-23

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