MX2013000827A - Composicion de tableta de unidad multiple. - Google Patents

Composicion de tableta de unidad multiple.

Info

Publication number: MX2013000827A
Authority: MX; Mexico
Prior art keywords: multiple unit; tablet composition; enteric coating; active ingredient; tablets
Prior art date: 2010-07-22

Application number

MX2013000827A

Other languages

English (en)

Spanish (es)

Inventor

Sunil Shantwan Borude

Shrenik Annasaheb Kole

Makrand Krishnakumar Avachat

Original Assignee

Lupin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-07-22

Filing date

2011-07-18

Publication date

2013-06-28

2011-07-18 Application filed by Lupin Ltd filed Critical Lupin Ltd

2013-06-28 Publication of MX2013000827A publication Critical patent/MX2013000827A/es

Links

239000007916 tablet composition Substances 0.000 title claims abstract description 29
239000002702 enteric coating Substances 0.000 claims abstract description 44
238000009505 enteric coating Methods 0.000 claims abstract description 44
239000003085 diluting agent Substances 0.000 claims abstract description 41
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 33
239000004480 active ingredient Substances 0.000 claims abstract description 27
239000004014 plasticizer Substances 0.000 claims abstract description 24
229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 23
235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 23
239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 19
229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 19
229920001688 coating polymer Polymers 0.000 claims abstract description 13
239000010410 layer Substances 0.000 claims description 22
238000000034 method Methods 0.000 claims description 17
239000011230 binding agent Substances 0.000 claims description 14
238000002360 preparation method Methods 0.000 claims description 12
230000008569 process Effects 0.000 claims description 10
235000000346 sugar Nutrition 0.000 claims description 7
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
239000000314 lubricant Substances 0.000 claims description 5
239000004094 surface-active agent Substances 0.000 claims description 5
239000000454 talc Substances 0.000 claims description 5
229910052623 talc Inorganic materials 0.000 claims description 5
235000012222 talc Nutrition 0.000 claims description 5
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
229930195725 Mannitol Natural products 0.000 claims description 4
239000000594 mannitol Substances 0.000 claims description 4
235000010355 mannitol Nutrition 0.000 claims description 4
238000002156 mixing Methods 0.000 claims description 4
238000000926 separation method Methods 0.000 claims description 4
239000000600 sorbitol Substances 0.000 claims description 4
235000010356 sorbitol Nutrition 0.000 claims description 4
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 3
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HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
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229910000019 calcium carbonate Inorganic materials 0.000 claims 1
235000010216 calcium carbonate Nutrition 0.000 claims 1
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 1
235000011132 calcium sulphate Nutrition 0.000 claims 1
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239000000832 lactitol Substances 0.000 claims 1
235000010448 lactitol Nutrition 0.000 claims 1
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
235000019731 tricalcium phosphate Nutrition 0.000 claims 1
238000004519 manufacturing process Methods 0.000 abstract description 10
239000003826 tablet Substances 0.000 description 77
239000000203 mixture Substances 0.000 description 30
239000002245 particle Substances 0.000 description 11
239000002253 acid Substances 0.000 description 9
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239000003472 antidiabetic agent Substances 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
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239000002220 antihypertensive agent Substances 0.000 description 1
229940030600 antihypertensive agent Drugs 0.000 description 1
239000003430 antimalarial agent Substances 0.000 description 1
229940125684 antimigraine agent Drugs 0.000 description 1
239000002282 antimigraine agent Substances 0.000 description 1
229940125710 antiobesity agent Drugs 0.000 description 1
239000002221 antipyretic Substances 0.000 description 1
229940125716 antipyretic agent Drugs 0.000 description 1
239000003899 bactericide agent Substances 0.000 description 1
239000011324 bead Substances 0.000 description 1
239000002876 beta blocker Substances 0.000 description 1
229960000074 biopharmaceutical Drugs 0.000 description 1
235000011116 calcium hydroxide Nutrition 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
229940105329 carboxymethylcellulose Drugs 0.000 description 1
229950008138 carmellose Drugs 0.000 description 1
239000000969 carrier Substances 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
239000007931 coated granule Substances 0.000 description 1
239000011247 coating layer Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
229940124558 contraceptive agent Drugs 0.000 description 1
239000003433 contraceptive agent Substances 0.000 description 1
229940099112 cornstarch Drugs 0.000 description 1
238000005336 cracking Methods 0.000 description 1
229960001681 croscarmellose sodium Drugs 0.000 description 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000002934 diuretic Substances 0.000 description 1
229940030606 diuretics Drugs 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
229940088679 drug related substance Drugs 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000012055 enteric layer Substances 0.000 description 1
229960004770 esomeprazole Drugs 0.000 description 1
SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 description 1
MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 1
239000010408 film Substances 0.000 description 1
230000009246 food effect Effects 0.000 description 1
239000003193 general anesthetic agent Substances 0.000 description 1
239000001087 glyceryl triacetate Substances 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
229960001269 glycine hydrochloride Drugs 0.000 description 1
159000000011 group IA salts Chemical class 0.000 description 1
239000007902 hard capsule Substances 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
238000007757 hot melt coating Methods 0.000 description 1
239000003906 humectant Substances 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
239000001341 hydroxy propyl starch Substances 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
235000013828 hydroxypropyl starch Nutrition 0.000 description 1
230000003345 hyperglycaemic effect Effects 0.000 description 1
239000003326 hypnotic agent Substances 0.000 description 1
230000000147 hypnotic effect Effects 0.000 description 1
229940126904 hypoglycaemic agent Drugs 0.000 description 1
230000002218 hypoglycaemic effect Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000007794 irritation Effects 0.000 description 1
229960003174 lansoprazole Drugs 0.000 description 1
MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical class [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
235000012254 magnesium hydroxide Nutrition 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229960003194 meglumine Drugs 0.000 description 1
238000007909 melt granulation Methods 0.000 description 1
229920003145 methacrylic acid copolymer Polymers 0.000 description 1
FYFFGSSZFBZTAH-UHFFFAOYSA-N methylaminomethanetriol Chemical compound CNC(O)(O)O FYFFGSSZFBZTAH-UHFFFAOYSA-N 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
239000008185 minitablet Substances 0.000 description 1
229940035363 muscle relaxants Drugs 0.000 description 1
239000003158 myorelaxant agent Substances 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
229960000381 omeprazole Drugs 0.000 description 1
239000003605 opacifier Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
229960005019 pantoprazole Drugs 0.000 description 1
150000003022 phthalic acids Chemical class 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
125000001453 quaternary ammonium group Chemical class 0.000 description 1
229960004157 rabeprazole Drugs 0.000 description 1
YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
CSMWJXBSXGUPGY-UHFFFAOYSA-L sodium dithionate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)S([O-])(=O)=O CSMWJXBSXGUPGY-UHFFFAOYSA-L 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
238000005563 spheronization Methods 0.000 description 1
238000005507 spraying Methods 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000000021 stimulant Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000013517 stratification Methods 0.000 description 1
JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
230000001975 sympathomimetic effect Effects 0.000 description 1
229940064707 sympathomimetics Drugs 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000006068 taste-masking agent Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229940124024 weight reducing agent Drugs 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

MX2013000827A 2010-07-22 2011-07-18 Composicion de tableta de unidad multiple. MX2013000827A (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN806KO2010		2010-07-22
PCT/IB2011/001658 WO2012010944A2 (fr)	2010-07-22	2011-07-18	Composition sous forme de comprimé à plusieurs unités

Publications (1)

Publication Number	Publication Date
MX2013000827A true MX2013000827A (es)	2013-06-28

Family

ID=44764185

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX2013000827A MX2013000827A (es)	2010-07-22	2011-07-18	Composicion de tableta de unidad multiple.

Country Status (10)

Country	Link
US (1)	US20130122090A1 (fr)
EP (1)	EP2595611A2 (fr)
JP (1)	JP2013531059A (fr)
AU (1)	AU2011281290A1 (fr)
BR (1)	BR112013000978A2 (fr)
MX (1)	MX2013000827A (fr)
NZ (1)	NZ607225A (fr)
PH (1)	PH12013500039A1 (fr)
WO (1)	WO2012010944A2 (fr)
ZA (1)	ZA201300304B (fr)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102940611B (zh) *	2012-11-26	2017-02-22	康普药业股份有限公司	一种含有埃索美拉唑镁的肠溶片剂
JP6608193B2 (ja) *	2014-06-27	2019-11-20	花王株式会社	固形状組成物
WO2016174664A1 (fr)	2015-04-29	2016-11-03	Dexcel Pharma Technologies Ltd.	Compositions à désintégration par voie orale
ES2607715B1 (es)	2015-10-01	2018-01-17	Solutex Na, Lcc	Proceso para la preparación y estabilización de emulsiones con omega-3 mediante redes cristalinas isométricas de derivados de celulosa
US10076494B2 (en)	2016-06-16	2018-09-18	Dexcel Pharma Technologies Ltd.	Stable orally disintegrating pharmaceutical compositions

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9402431D0 (sv)	1994-07-08	1994-07-08	Astra Ab	New tablet formulation
US6228400B1 (en) *	1999-09-28	2001-05-08	Carlsbad Technology, Inc.	Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same
AU6786001A (en) *	2000-07-05	2002-01-14	Asahi Chemical Ind	Cellulose powder
ES2198195B1 (es) *	2001-12-18	2004-10-01	Laboratorios Del Dr. Esteve, S.A.	Forma de dosificacion farmaceutica oral comprimida, con recubrimiento enterico, que contiene un compuesto de bencimidazol labil en medio acido.
CA2472103A1 (fr) *	2002-01-25	2003-08-07	Santarus, Inc.	Administration par voie muqueuse d'inhibiteurs de la pompe a protons
WO2004089333A2 (fr) *	2003-02-28	2004-10-21	Cadila Healthcare Limited	Formulation de benzimidazole stable
CL2004000983A1 (es) *	2003-05-08	2005-03-04	Altana Pharma Ag	Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
WO2005092297A2 (fr) *	2004-03-03	2005-10-06	Teva Pharmaceutical Industries Ltd.	Composition pharmaceutique stable comprenant un medicament labile en milieu acide
EP1830822A1 (fr) *	2004-12-24	2007-09-12	LEK Pharmaceuticals D.D.	Composition pharmaceutique stable comprenant un substance active sous la forme d'une solution solide
US20080107727A1 (en) *	2005-01-31	2008-05-08	Katashi Nakashima	Multiple Unit Oral Sustained Release Preparation and Production Method Thereof
WO2007055329A1 (fr) *	2005-11-11	2007-05-18	Asahi Kasei Chemicals Corporation	Preparation solide a liberation controlee
WO2007122478A2 (fr) *	2006-04-20	2007-11-01	Themis Laboratories Private Limited	Compositions à unités multiples
US20090291136A1 (en)	2006-07-11	2009-11-26	Lek Pharmaceuticals D.D.	Multiple Unit Tablets
CA2667039A1 (fr)	2006-10-17	2008-04-24	Ranbaxy Laboratories Limited	Composition de comprimes a multiples unites de composes de benzimidazole

2011
- 2011-07-18 JP JP2013520230A patent/JP2013531059A/ja active Pending
- 2011-07-18 EP EP11767055.4A patent/EP2595611A2/fr not_active Withdrawn
- 2011-07-18 AU AU2011281290A patent/AU2011281290A1/en not_active Abandoned
- 2011-07-18 BR BR112013000978A patent/BR112013000978A2/pt not_active IP Right Cessation
- 2011-07-18 WO PCT/IB2011/001658 patent/WO2012010944A2/fr not_active Ceased
- 2011-07-18 MX MX2013000827A patent/MX2013000827A/es unknown
- 2011-07-18 PH PH1/2013/500039A patent/PH12013500039A1/en unknown
- 2011-07-18 US US13/811,327 patent/US20130122090A1/en not_active Abandoned
- 2011-07-18 NZ NZ607225A patent/NZ607225A/en not_active IP Right Cessation
2013
- 2013-01-11 ZA ZA2013/00304A patent/ZA201300304B/en unknown

Also Published As

Publication number	Publication date
BR112013000978A2 (pt)	2017-07-11
EP2595611A2 (fr)	2013-05-29
NZ607225A (en)	2015-02-27
AU2011281290A1 (en)	2013-02-14
ZA201300304B (en)	2013-09-25
JP2013531059A (ja)	2013-08-01
WO2012010944A3 (fr)	2012-05-18
US20130122090A1 (en)	2013-05-16
PH12013500039A1 (en)	2013-02-18
WO2012010944A2 (fr)	2012-01-26

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WO2008064202A2 (fr)	2008-05-29	Formulations à libération modifiée de composés actifs vis-à-vis du récepteur de calcium
US20080003281A1 (en)	2008-01-03	Modified Release Tablet Formulations for Proton Pump Inhibitors
EP2040684B1 (fr)	2013-01-23	Tablette aux unites multiples
US8753682B2 (en)	2014-06-17	Dual release oral tablet compositions of dexlansoprazole
WO2011140446A2 (fr)	2011-11-10	Formulations pharmaceutiques
JP2015500853A (ja)	2015-01-08	即時放出マルチユニットペレットシステム
KR102727681B1 (ko)	2024-11-07	덱스란소프라졸 또는 이의 약학적으로 허용 가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102286498B1 (ko)	2021-08-05	레날리도마이드의 경구용 코팅 정제 조성물
WO2015145462A1 (fr)	2015-10-01	Compositions pharmaceutiques de dabigatran
EP2601936A1 (fr)	2013-06-12	Composition comprimée
EP1833469A2 (fr)	2007-09-19	Composition pharmaceutique de substances labiles acides
MX2013000827A (es)	2013-06-28	Composicion de tableta de unidad multiple.
WO2021018414A1 (fr)	2021-02-04	Composition pharmaceutique comprenant du dabigatran étexilate
US20060024362A1 (en)	2006-02-02	Composition comprising a benzimidazole and process for its manufacture
EP3532028B1 (fr)	2025-08-20	Compositions pharmaceutiques comprenant un ester d'acide fumarique et leur procédé de préparation
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