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MX2012005509A - Proceso para convertir un copolímero de (met) acrilato sólido en una forma dispersada por medio de un agente dispersante. - Google Patents

Proceso para convertir un copolímero de (met) acrilato sólido en una forma dispersada por medio de un agente dispersante.

Info

Publication number
MX2012005509A
MX2012005509A MX2012005509A MX2012005509A MX2012005509A MX 2012005509 A MX2012005509 A MX 2012005509A MX 2012005509 A MX2012005509 A MX 2012005509A MX 2012005509 A MX2012005509 A MX 2012005509A MX 2012005509 A MX2012005509 A MX 2012005509A
Authority
MX
Mexico
Prior art keywords
meth
acrylate copolymer
solid
dispersed form
dispersing agent
Prior art date
Application number
MX2012005509A
Other languages
English (en)
Inventor
Kathrin Nollenberger
Erna Roth
Ruediger Alexowsky
Hans-Ulrich Petereit
Christian Meier
Original Assignee
Evonik Roehm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm Gmbh filed Critical Evonik Roehm Gmbh
Publication of MX2012005509A publication Critical patent/MX2012005509A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/05—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from solid polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2333/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters
    • C08J2333/14—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

La presente invención proporciona un proceso para convertir un copolímero sólido de 8met) acrilato en una forma dispersada preparando una dispersión acuosa que contiene los siguientes componentes (a) Un copolímero de (met) acrilato compuesto de metacrilato de metilo polimerizado por radicales libres, etilacrilato y una sal de metacrilato 2-trimetilamoniometilo presente en forma sólida como polvo o granulado, (b) hasta 50% en peso calculado con base en el copolímero de (met) acrilato de un agente dispersante seleccionado de los grupos (b) i) agentes plastificantes en combinación con agentes emulsificantes y/o (b) ii) hidratos de carbono farmacéuticamente aceptables con 6 a18 átomos de carbono con un grupo funcional y (c) Agua Mezclando los componentes (a), (b) y (c) para obtener una suspensión que se convierte en una dispersión acuosa durante la conversión del copolímero sólido de (met) acrilato en la forma dispersada, caracterizada porque el copolímero de (met) acrilato se convierte en la forma dispersada por medio de la presencia del agente dispersante a una temperatura menor que 50°c.
MX2012005509A 2009-11-16 2009-11-16 Proceso para convertir un copolímero de (met) acrilato sólido en una forma dispersada por medio de un agente dispersante. MX2012005509A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2009/065244 WO2011057676A1 (en) 2009-11-16 2009-11-16 A process for converting a solid (meth)acrylate copolymer into a dispersed form by means of a dispersing agent

Publications (1)

Publication Number Publication Date
MX2012005509A true MX2012005509A (es) 2012-08-15

Family

ID=42306647

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012005509A MX2012005509A (es) 2009-11-16 2009-11-16 Proceso para convertir un copolímero de (met) acrilato sólido en una forma dispersada por medio de un agente dispersante.

Country Status (11)

Country Link
US (1) US9284416B2 (es)
EP (1) EP2501368B1 (es)
JP (1) JP5907881B2 (es)
KR (1) KR20120110098A (es)
CN (1) CN102665695A (es)
BR (1) BR112012011554A2 (es)
CA (1) CA2780948C (es)
ES (1) ES2671036T3 (es)
IL (1) IL219270A0 (es)
MX (1) MX2012005509A (es)
WO (1) WO2011057676A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE033556T2 (hu) 2009-07-30 2017-12-28 Evonik Roehm Gmbh Kopolimert, dikarbonsavat és zsír-monokarbonsavat tartalmazó poralakú- vagy granulált készítmény
GB201202433D0 (en) * 2012-02-13 2012-03-28 Diurnal Ltd Controlled drug release
JP6553864B2 (ja) * 2014-11-19 2019-07-31 Ｊｘｔｇエネルギー株式会社 シールド掘進機用テールシール組成物
CN109627458B (zh) * 2018-12-14 2021-11-12 英德茂丰药业有限公司 一种含季铵基(甲基)丙烯酸酯共聚物水分散体的制备方法
JP2023516495A (ja) * 2020-03-11 2023-04-19 エボニック オペレーションズ ゲーエムベーハー グリコリピドおよびクエン酸トリエチルを含む混合組成物
CN112420393B (zh) * 2020-11-17 2022-10-14 益阳市万京源电子有限公司 一种耐高压的电解液及铝电解电容器
CN114306265A (zh) * 2021-12-29 2022-04-12 悦康药业集团安徽天然制药有限公司 季铵基甲基丙烯酸酯共聚物a型水分散体及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438291A1 (de) * 1984-10-19 1986-04-24 Röhm GmbH, 6100 Darmstadt Verfahren zur herstellung einer waessrigen ueberzugsmitteldispersion und ihre verwendung zum ueberziehen von arzneimitteln
JPH0273011A (ja) 1988-07-28 1990-03-13 Warner Lambert Co 医薬投与剤型製造用のセルロースおよびアクリル系重合体の水性重合体分散体およびその投与剤型
JP2527150B2 (ja) 1989-07-25 1996-08-21 豊信 吉田 マイクロ波熱プラズマ・ト―チ
DE4213283A1 (de) * 1992-04-23 1993-10-28 Basf Ag Verwendung von Copolymerisaten aus Carbonsäuren und langkettigen Verbindungen mit isolierten C-C-Mehrfachverbindungen als Verdickungs- oder Dispergiermittel
US5587149A (en) * 1995-02-06 1996-12-24 R.P. Scherer Corporation Topical application emulsions
JP4275768B2 (ja) 1998-06-18 2009-06-10 久光製薬株式会社 水性粘着膏体
AUPP494798A0 (en) * 1998-07-29 1998-08-20 Pacific Biolink Pty Limited Protective protein formulation
DE19929008A1 (de) 1999-06-24 2001-01-11 Wacker Polymer Systems Gmbh Verfahren zur Herstellung von in Wasser redispergierbaren Vinylaromat-Mischpolymerisat- Redispersionspulvern
DE10013029A1 (de) * 2000-03-17 2001-09-20 Roehm Gmbh Mehrschichtige Arzneiform für die Colonfreigabe
GB0018968D0 (en) 2000-08-02 2000-09-20 Pfizer Ltd Particulate composition
EP1423092A2 (en) 2001-09-05 2004-06-02 Vectura Limited Functional powders for oral delivery
DE10200578A1 (de) 2002-01-09 2003-07-10 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme
JP4691925B2 (ja) 2004-08-05 2011-06-01 田辺三菱製薬株式会社 圧縮成型製剤の製造方法
HUE033556T2 (hu) 2009-07-30 2017-12-28 Evonik Roehm Gmbh Kopolimert, dikarbonsavat és zsír-monokarbonsavat tartalmazó poralakú- vagy granulált készítmény

Also Published As

Publication number Publication date
CA2780948A1 (en) 2011-05-19
KR20120110098A (ko) 2012-10-09
WO2011057676A1 (en) 2011-05-19
US20120208832A1 (en) 2012-08-16
JP5907881B2 (ja) 2016-04-26
JP2013510937A (ja) 2013-03-28
US9284416B2 (en) 2016-03-15
ES2671036T3 (es) 2018-06-04
BR112012011554A2 (pt) 2016-06-28
CA2780948C (en) 2017-06-27
CN102665695A (zh) 2012-09-12
EP2501368A1 (en) 2012-09-26
IL219270A0 (en) 2012-06-28
EP2501368B1 (en) 2018-04-18

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