[go: up one dir, main page]

MX2012004619A - Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas. - Google Patents

Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas.

Info

Publication number
MX2012004619A
MX2012004619A MX2012004619A MX2012004619A MX2012004619A MX 2012004619 A MX2012004619 A MX 2012004619A MX 2012004619 A MX2012004619 A MX 2012004619A MX 2012004619 A MX2012004619 A MX 2012004619A MX 2012004619 A MX2012004619 A MX 2012004619A
Authority
MX
Mexico
Prior art keywords
oncogenic fusion
fusion proteins
present
proximity
detecting
Prior art date
Application number
MX2012004619A
Other languages
English (en)
Other versions
MX337666B (es
Inventor
Sharat Singh
Xinjun Liu
Original Assignee
Prometheus Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prometheus Lab Inc filed Critical Prometheus Lab Inc
Publication of MX2012004619A publication Critical patent/MX2012004619A/es
Publication of MX337666B publication Critical patent/MX337666B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente invención proporciona matrices basadas en anticuerpos para detectar el estado de activación cantidad total y/o cantidad total de una o una pluralidad de proteínas de fusión oncogénicas en una muestra biológica como sangre con todas sus fracciones o tejido tumoral y métodos de uso de lo mismo. En ciertos casos, el estado de activación y/o la cantidad total de proteínas de fusión oncogénicas presentes en una muestra puede cuantificarse combinada con una o una pluralidad de moléculas de la transducción de señal. Las composiciones y métodos de la presente invención tienen las ventajas de especificidad asociada a ensayos de inmunoabsorción enzimática, sensibilidad asociada con amplificación de la señal y multiplexión de alto rendimiento asociada con micromatrices.
MX2012004619A 2009-10-20 2010-10-20 Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas. MX337666B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25339309P 2009-10-20 2009-10-20
US30508410P 2010-02-16 2010-02-16
US32748710P 2010-04-23 2010-04-23
US38303710P 2010-09-15 2010-09-15
PCT/US2010/053386 WO2011050069A1 (en) 2009-10-20 2010-10-20 Proximity-mediated assays for detecting oncogenic fusion proteins

Publications (2)

Publication Number Publication Date
MX2012004619A true MX2012004619A (es) 2012-05-08
MX337666B MX337666B (es) 2016-03-14

Family

ID=43242385

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012004619A MX337666B (es) 2009-10-20 2010-10-20 Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas.

Country Status (16)

Country Link
US (1) US20120277109A1 (es)
EP (1) EP2491385B1 (es)
JP (3) JP5819307B2 (es)
KR (1) KR20120110168A (es)
CN (1) CN102667478B (es)
AU (1) AU2010310746B2 (es)
BR (1) BR112012009296A2 (es)
CA (1) CA2777934A1 (es)
DK (1) DK2491385T3 (es)
ES (1) ES2637853T3 (es)
IL (1) IL219313A (es)
MX (1) MX337666B (es)
NZ (1) NZ599460A (es)
RU (1) RU2558797C2 (es)
WO (1) WO2011050069A1 (es)
ZA (1) ZA201202957B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120065092A1 (en) * 2010-09-14 2012-03-15 Wai Hobert Fusion analyte cytometric bead assay, and systems and kits for performing the same
MX2013007429A (es) 2010-12-23 2014-01-31 Nestec Sa Seleccion de farmacos para terapia de cancer maligno usando disposiciones a base de anticuerpos.
ES2530175T3 (es) 2011-02-17 2015-02-26 Nestec S.A. Ensayos para la detección de autoanticuerpos contra fármacos anti-TNF
WO2012119113A2 (en) 2011-03-02 2012-09-07 Nestec Sa Prediction of drug sensitivity of lung tumors based on molecular and genetic signatures
CN102676648A (zh) * 2011-03-07 2012-09-19 重庆医科大学附属儿童医院 白血病诊疗的基因芯片
SG10201601301RA (en) 2011-04-04 2016-03-30 Nestec Sa Methods for predicting and improving the survival of gastric cancer patients
CN110544517A (zh) 2011-05-10 2019-12-06 雀巢产品有限公司 用于个体化治疗管理的疾病活动性表征方法
MX2013013054A (es) * 2011-05-12 2014-02-20 Genentech Inc Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura.
US9804160B2 (en) * 2011-09-28 2017-10-31 H. Lee Moffitt Cancer Center And Research Institute, Inc. Protein-protein interaction as biomarkers
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
EP2788752B1 (en) 2011-12-05 2018-10-03 Pierian Holdings, Inc. Method of therapy selection for patients with lung cancer
PL2812024T3 (pl) * 2012-02-09 2018-09-28 Var2 Pharmaceuticals Aps Celowanie glikanów siarczanu chondroityny
WO2013148498A1 (en) 2012-03-27 2013-10-03 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
JP2014030572A (ja) * 2012-08-03 2014-02-20 Akira Sakai 抗がん剤投与装置
US9422602B2 (en) 2012-08-15 2016-08-23 Bio-Rad Laboratories, Inc. Methods and compositions for determining nucleic acid degradation
EP2904405B1 (en) 2012-10-05 2017-05-31 Nestec S.A. Methods for predicting and monitoring mucosal healing
CN103792364B (zh) * 2012-10-31 2016-06-08 张宝弘 用于检测外周血中循环肿瘤细胞ror1蛋白的试剂及其应用
EP2954328A1 (en) 2013-02-05 2015-12-16 Nestec S.A. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
WO2014122600A1 (en) 2013-02-05 2014-08-14 Nestec S.A. Methods of selecting combination therapy for colorectal cancer patients
HK1218939A1 (zh) 2013-02-05 2017-03-17 Nestec S.A. 用於非小细胞肺癌疗法的药物选择
CN104007257B (zh) * 2013-02-24 2017-02-08 北京莱尔生物医药科技有限公司 一种检测非体液性稀有有核细胞的方法和试剂盒
WO2014141306A2 (en) * 2013-03-15 2014-09-18 Rajiv Gandhi Centre For Biotechnology Methods and materials for identifying therapeutic response in chronic myeloid leukemia
MX2015016065A (es) 2013-05-21 2016-03-21 Nestec Sa Metodos para predecir y mejorar la supervivencia de pacientes de cancer colorrectal.
WO2015110989A1 (en) 2014-01-23 2015-07-30 Nestec S.A. Biomarker panel for assessment of mucosal healing
GB2524519B (en) 2014-03-25 2019-11-06 Pelago Bioscience AB Methods for identifying a biomarker indicative of a reduced drug response using a thermal shift assay
WO2016000966A1 (en) * 2014-06-30 2016-01-07 Nestec S.A. Collaborative enzyme enhanced reactive (ceer) immunoassay using flow cytometry
CA2964857A1 (en) 2014-10-20 2016-04-28 Nestec S.A. Methods for prediction of anti-tnf alpha drug levels and autoantibody formation
US11149299B2 (en) * 2015-06-25 2021-10-19 Ramesh Vallabhaneni Method and system for multiplex profiling of chromosomes in biological samples using target-specific DNA probes
TWI734775B (zh) * 2016-04-26 2021-08-01 美商美國泰福生技股份有限公司 細胞培養基
CN106645728A (zh) * 2016-11-09 2017-05-10 百奥森（江苏）食品安全科技有限公司 一种食品中氟喹诺酮类药物的检测试剂盒
US10799503B2 (en) 2016-12-01 2020-10-13 Ignyta, Inc. Methods for the treatment of cancer
US10852274B2 (en) 2017-03-09 2020-12-01 Auburn University Differential circuit for background correction in electrochemical measurements
KR20180117529A (ko) * 2017-04-19 2018-10-29 주식회사 프로티나 단백질-단백질 상호작용 분석에 의한 약물 반응성 예측 방법
AU2018277256A1 (en) 2017-05-31 2020-01-30 Prometheus Biosciences, Inc. Methods for assessing mucosal healing in Crohn's disease patients
US11505799B2 (en) 2017-07-07 2022-11-22 Innamed, Inc. Aptamers for measuring lipoprotein levels
US11560565B2 (en) 2018-06-13 2023-01-24 Auburn University Electrochemical detection nanostructure, systems, and uses thereof
CN109439759A (zh) * 2018-12-18 2019-03-08 武汉迪安医学检验实验室有限公司 一种用于检测CBFβ-MYH11融合基因的试剂盒
WO2020140927A1 (en) * 2019-01-02 2020-07-09 Crownmab Biotech Inc. Cancer treatment using multi-targeted kinase inhibitor in combination of protein kinase biomarkers
WO2023286723A1 (ja) 2021-07-13 2023-01-19 キヤノン株式会社 検体の分析方法および検体分析装置
WO2023058624A1 (ja) * 2021-10-08 2023-04-13 コニカミノルタ株式会社 染色方法、評価方法および標本
CN119020510A (zh) * 2024-10-31 2024-11-26 江苏谱新生物医药有限公司 检测k562工程细胞残留的引物探针组合物、试剂盒和方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197199A (en) 1977-10-25 1980-04-08 Manor Engineering Company Limited Filter presses
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5532138A (en) 1990-04-26 1996-07-02 Behringwerke Ag Method and kits for determining peroxidatively active catalysts
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
WO1992021032A1 (en) 1991-05-24 1992-11-26 The Regents Of The University Of California Methods for the detection of bcr-abl and abnormal abl proteins in leukemia patients
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
EP1997894B1 (en) 1992-02-06 2011-03-30 Novartis Vaccines and Diagnostics, Inc. Biosynthetic binding protein for cancer marker
JP3571337B2 (ja) 1992-02-11 2004-09-29 セル ジェネシス，インコーポレーテッド 遺伝子標的現象による同型遺伝子接合
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5332662A (en) 1992-07-31 1994-07-26 Syntex (U.S.A.) Inc. Methods for determining peroxidatively active substances
CA2140280A1 (en) 1992-08-17 1994-03-03 Avi J. Ashkenazi Bispecific immunoadhesins
US5618829A (en) 1993-01-28 1997-04-08 Mitsubishi Chemical Corporation Tyrosine kinase inhibitors and benzoylacrylamide derivatives
WO1995002420A2 (en) 1993-07-15 1995-01-26 Cancer Research Campaign Technology Ltd. Prodrugs of protein tyrosine kinase inhibitors
AU7408094A (en) * 1993-07-29 1995-02-28 Cor Therapeutics, Inc. Receptor function assays
WO1995006877A1 (en) 1993-09-03 1995-03-09 Behringwerke Ag Fluorescent oxygen channeling immunoassays
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US6107457A (en) 1995-02-16 2000-08-22 Board Of Regents, The University Of Texas System Bcr-Abl directed compositions and uses for inhibiting Philadelphia chromosome stimulated cell growth
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5639757A (en) 1995-05-23 1997-06-17 Pfizer Inc. 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors
EA001595B1 (ru) 1996-04-12 2001-06-25 Варнер-Ламберт Компани Необратимые ингибиторы тирозинкиназ
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
EP0983510B1 (en) 1997-05-20 2004-03-03 Erasmus Universiteit Rotterdam Recognition of tumour-specific gene products in cancer
US6686165B2 (en) 1997-05-20 2004-02-03 Erasmus Universiteit Rotterdam Recognition of tumor-specific gene products in cancer
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
US6780582B1 (en) 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6197599B1 (en) 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
US6740665B1 (en) 1999-02-10 2004-05-25 Ramachandran Murali Tyrosine kinase inhibitors and methods of using the same
US6245759B1 (en) 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
JP2003503354A (ja) 1999-06-30 2003-01-28 メルク エンド カムパニー インコーポレーテッド Ｓｒｃキナーゼ阻害剤化合物
US6498165B1 (en) 1999-06-30 2002-12-24 Merck & Co., Inc. Src kinase inhibitor compounds
WO2001000207A1 (en) 1999-06-30 2001-01-04 Merck & Co., Inc. Src kinase inhibitor compounds
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
CN1390215A (zh) 1999-09-10 2003-01-08 麦克公司 酪氨酸激酶抑制剂
ATE290865T1 (de) 1999-10-19 2005-04-15 Merck & Co Inc Tyrosin kinase inhibitoren
EP1226136B1 (en) 1999-10-19 2004-12-29 Merck & Co., Inc. Tyrosine kinase inhibitors
US6794393B1 (en) 1999-10-19 2004-09-21 Merck & Co., Inc. Tyrosine kinase inhibitors
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2002012893A2 (en) 2000-08-03 2002-02-14 Massachusetts Institute Of Technology Microarrays of functional biomolecules, and uses therefor
US20020132274A1 (en) * 2001-01-17 2002-09-19 Nevalainen Marja T. Diagnostic and monitorings methods for cancer
WO2002084252A2 (en) 2001-04-17 2002-10-24 Xenoport, Inc. Epitope-captured antibody display
AU2002346053B2 (en) 2001-06-22 2008-03-13 Merck & Co., Inc. Tyrosine kinase inhibitors
US6958340B2 (en) 2001-08-01 2005-10-25 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003020276A1 (en) 2001-08-30 2003-03-13 Merck & Co., Inc. Tyrosine kinase inhibitors
US20030190689A1 (en) * 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies
US20030153013A1 (en) 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
US7354773B2 (en) * 2003-05-14 2008-04-08 Beckman Coulter, Inc. Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry
EP1507147A1 (en) * 2003-08-12 2005-02-16 Erasmus University Medical Center Rotterdam Method for detecting low levels of a fusion protein
US20050214301A1 (en) 2004-03-24 2005-09-29 Cell Signaling Technology, Inc. Antibodies specific for BCR-ABL fusion protein and uses thereof
US20060263837A1 (en) 2004-06-17 2006-11-23 Liu George D Immunoassay system and method for detection of antigens
US7771955B2 (en) 2005-06-09 2010-08-10 University Of Maryland Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule
DE212006000071U1 (de) * 2005-11-18 2008-07-24 Board of Regents, The University of Texas System, Austin Quantifizierung von Fusionsproteinen und ihrer Aktivität in Folge chromosomaler Translokation
US9250243B2 (en) 2006-09-21 2016-02-02 Nestec S.A. Drug selection for lung cancer therapy using antibody-based arrays
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
CA2664108C (en) * 2006-09-21 2016-01-26 Prometheus Laboratories Inc. Antibody-based arrays for detecting multiple signal transducers in rare circulating cells
JP2008261764A (ja) * 2007-04-13 2008-10-30 Kyowa Hakko Kogyo Co Ltd キナーゼ阻害物質の測定方法
GB0714573D0 (en) * 2007-07-26 2007-09-05 Imp Innovations Ltd Marker gene
AU2008289442A1 (en) * 2007-08-21 2009-02-26 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
JP5228416B2 (ja) * 2007-09-12 2013-07-03 株式会社リコー 定電流出力制御型スイッチングレギュレータ
NZ617520A (en) * 2008-02-25 2015-05-29 Nestec Sa Drug selection for breast cancer therapy using antibody-based arrays
EP2108956A1 (en) * 2008-04-07 2009-10-14 Erasmus University Medical Center Rotterdam Improved methods and kits for detecting tumor-specific fusion proteins
US8301258B2 (en) 2008-08-14 2012-10-30 The Chinese University Of Hong Kong Methods and devices for preventing ankle sprain injuries

Also Published As

Publication number Publication date
EP2491385A1 (en) 2012-08-29
US20120277109A1 (en) 2012-11-01
CN102667478B (zh) 2018-06-01
JP2018119975A (ja) 2018-08-02
NZ599460A (en) 2014-07-25
DK2491385T3 (en) 2017-08-28
ES2637853T3 (es) 2017-10-17
MX337666B (es) 2016-03-14
IL219313A (en) 2017-03-30
RU2012120722A (ru) 2013-11-27
JP5819307B2 (ja) 2015-11-24
JP2016028251A (ja) 2016-02-25
AU2010310746B2 (en) 2015-07-23
BR112012009296A2 (pt) 2021-02-02
KR20120110168A (ko) 2012-10-09
EP2491385B1 (en) 2017-05-10
WO2011050069A1 (en) 2011-04-28
IL219313A0 (en) 2012-06-28
ZA201202957B (en) 2017-01-25
JP2013508728A (ja) 2013-03-07
CA2777934A1 (en) 2011-04-28
JP6301892B2 (ja) 2018-03-28
CN102667478A (zh) 2012-09-12
RU2558797C2 (ru) 2015-08-10
AU2010310746A1 (en) 2012-05-03

Similar Documents

Publication Publication Date Title
MX2012004619A (es) Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas.
WO2008021290A9 (en) Organ-specific proteins and methods of their use
MX2010009766A (es) Ensayo de proteasa.
WO2008070865A3 (en) Materials and methods for efficient and accurate detection of analytes
ES2570731T3 (es) Método de detección de cáncer
WO2007114986A3 (en) Cooperative probes and methods of using them
SG10201408392PA (en) Methods of determining patient response by measurement of her-3
EP2013561A4 (en) BINARY PROBES FOR FLUORESCENCE ANALYSIS OF NUCLEIC ACIDS
BRPI1013688A8 (pt) Proteínas de ligação de il-17.
ATE471512T1 (de) Verwendung des proteins s100a 12 als marker für kolorektalkarzinom
ATE554389T1 (de) Apex als marker für lungenkrebs
CY1112553T1 (el) Ανοσοπροσδιορισμοι υψηλης ευαισθησιας και κιτια για τον προσδιορισμο πεπτιδιων και πρωτεϊνων βιολογικου ενδιαφεροντος
WO2010046443A3 (en) Methods for detection and diagnosis of a bone or cartilage disorder
TR201907065T4 (tr) Aptamer kullanarak hedef maddeyi tespit yöntemi.
WO2009019370A3 (fr) Procede de dosage de l'apolipoproteine aii pour le diagnostic in vitro du cancer colorectal
MX2009010751A (es) Composiciones y metodos de deteccion.
WO2006113245A3 (en) Methods for measuring glycan levels of proteins
PE20120592A1 (es) Metodo con biomarcadores para el seguimiento de un tratamiento
ATE468535T1 (de) Verwendung von nnmt als marker für lungenkrebs
ATE462803T1 (de) Kit und verfahren zum nachweis von urothelkarzinom
ATE333521T1 (de) Detektion von vancomycin-resistenten enterococcus-subspezies
WO2006076687A3 (en) Elisa assays using prion-specific peptide reagents
MX2012000041A (es) Metodo para someter a prueba a un sujeto que se cree esta predispuesto a tener cancer metastasico usando delta133p53beta.
WO2010000467A8 (en) Asc as a marker for lung cancer
WO2008090177A3 (en) Diagnosis of prostate cancer

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: NESTEC S.A.

FG Grant or registration