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MX2012004020A - Analogos de heterociclilo pirazolopirimidina como inhibidores de jak. - Google Patents

Analogos de heterociclilo pirazolopirimidina como inhibidores de jak.

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Publication number
MX2012004020A
MX2012004020A MX2012004020A MX2012004020A MX2012004020A MX 2012004020 A MX2012004020 A MX 2012004020A MX 2012004020 A MX2012004020 A MX 2012004020A MX 2012004020 A MX2012004020 A MX 2012004020A MX 2012004020 A MX2012004020 A MX 2012004020A
Authority
MX
Mexico
Prior art keywords
sup
compounds
jak inhibitors
heterocyclyl
analogues
Prior art date
Application number
MX2012004020A
Other languages
English (en)
Inventor
Richard John Harrison
Cyrille Boussard
Kathryn Bell
Sally Oxenford
Nigel Ramsden
Nelly Piton
Claudio Dagostin
Andrew Ratcliffe
Original Assignee
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ltd filed Critical Cellzome Ltd
Publication of MX2012004020A publication Critical patent/MX2012004020A/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Gastroenterology & Hepatology (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I) (ver fórmula (I)) donde X1 a X5, Y, Z1 a Z3, y R tienen el significado indicado en la descripción y las reivindicaciones. Dichos compuestos son útiles como inhibidores de JAK para el tratamiento o la profilaxis de trastornos inmunológicos, inflamatorios, autoinmunes, alérgicos, y enfermedades mediadas por el sistema inmunológico. La invención también se refiere a composiciones farmacéuticas que incluyen dichos compuestos, la preparación de dichos compuestos al igual que su uso como medicamentos.
MX2012004020A 2009-10-20 2010-10-19 Analogos de heterociclilo pirazolopirimidina como inhibidores de jak. MX2012004020A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09173535 2009-10-20
US37535810P 2010-08-20 2010-08-20
PCT/EP2010/065700 WO2011048082A1 (en) 2009-10-20 2010-10-19 Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors

Publications (1)

Publication Number Publication Date
MX2012004020A true MX2012004020A (es) 2012-05-08

Family

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Family Applications (1)

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MX2012004020A MX2012004020A (es) 2009-10-20 2010-10-19 Analogos de heterociclilo pirazolopirimidina como inhibidores de jak.

Country Status (15)

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US (1) US9242987B2 (es)
EP (1) EP2491039A1 (es)
JP (1) JP5744887B2 (es)
KR (1) KR20120102601A (es)
CN (1) CN102666545B (es)
AR (1) AR078675A1 (es)
AU (1) AU2010309882B2 (es)
BR (1) BR112012009327A2 (es)
CA (1) CA2775009A1 (es)
EA (1) EA022120B1 (es)
IL (1) IL218751A0 (es)
MX (1) MX2012004020A (es)
NZ (1) NZ598907A (es)
TW (1) TW201125867A (es)
WO (1) WO2011048082A1 (es)

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