[go: up one dir, main page]

MX2012001449A - Inhibidores de cinasas c-jun-n-terminales (jnk). - Google Patents

Inhibidores de cinasas c-jun-n-terminales (jnk).

Info

Publication number
MX2012001449A
MX2012001449A MX2012001449A MX2012001449A MX2012001449A MX 2012001449 A MX2012001449 A MX 2012001449A MX 2012001449 A MX2012001449 A MX 2012001449A MX 2012001449 A MX2012001449 A MX 2012001449A MX 2012001449 A MX2012001449 A MX 2012001449A
Authority
MX
Mexico
Prior art keywords
sup
jnk
inhibitors
compounds
disclosed
Prior art date
Application number
MX2012001449A
Other languages
English (en)
Inventor
Wylie Solang Palmer
Lubica Raptova
Leyi Gong
Xiaochun Han
Ferenc Makra
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2012001449A publication Critical patent/MX2012001449A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a inhibidores de las JNK y a los correspondientes métodos, formulaciones y composiciones para inhibir las JNK y tratar los trastornos mediados por las JNK. La solicitud describe inhibidores de las JNK, que se ajustan a la siguiente fórmula I: (ver fórmula (I)) en donde p, q, Y', r, R1, R2, X, X1, X2, X3, y tienen los significados aquí definidos. Los compuestos y composiciones aquí descritos, son útiles para modular la actividad de las JNK y tratar enfermedades asociadas con la actividad de las JNK. Se describen métodos y formulaciones para inhibir las JNK y tratar los trastornos mediados por las JNK y similares, con los compuestos y procesos para obtener los compuestos, y las correspondientes composiciones, aquí descritas.
MX2012001449A 2009-08-10 2010-08-06 Inhibidores de cinasas c-jun-n-terminales (jnk). MX2012001449A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23252209P 2009-08-10 2009-08-10
PCT/EP2010/061476 WO2011018417A1 (en) 2009-08-10 2010-08-06 Inhibitors of jnk

Publications (1)

Publication Number Publication Date
MX2012001449A true MX2012001449A (es) 2012-03-26

Family

ID=42710723

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001449A MX2012001449A (es) 2009-08-10 2010-08-06 Inhibidores de cinasas c-jun-n-terminales (jnk).

Country Status (15)

Country Link
US (1) US8536172B2 (es)
EP (1) EP2464640A1 (es)
JP (1) JP5784604B2 (es)
KR (1) KR101506318B1 (es)
CN (1) CN102471319B (es)
AR (1) AR077820A1 (es)
AU (1) AU2010283769B2 (es)
BR (1) BR112012003059A2 (es)
CA (1) CA2768749A1 (es)
IL (1) IL217756A0 (es)
IN (1) IN2012DN01231A (es)
MX (1) MX2012001449A (es)
SG (1) SG178321A1 (es)
TW (1) TW201109336A (es)
WO (1) WO2011018417A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012013438A (es) * 2010-06-04 2013-01-22 Hoffmann La Roche Inhibidores de cinasa del extremo n-terminal de c-jun (jnk).
JP6109937B2 (ja) * 2012-07-20 2017-04-05 クリーブ バイオサイエンシズ インコーポレイテッド ｐ９７複合体の阻害剤としての融合ピリミジン
CA2903275A1 (en) * 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
SG11201608242XA (en) * 2014-04-04 2016-10-28 Syros Pharmaceuticals Inc Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2016100909A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF
CN107567453A (zh) * 2015-03-13 2018-01-09 艾伯维公司 (吲唑‑4‑基)六氢吡咯并吡咯酮类及使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2662998C (en) * 2006-09-08 2015-10-06 F. Hoffmann-La Roche Ag Benzotriazole kinase modulators
MX2009005508A (es) * 2006-12-08 2009-06-03 Hoffmann La Roche Pirimidinas substituidas y su uso como moduladores de cinasas c-jun n-terminales.

Also Published As

Publication number Publication date
TW201109336A (en) 2011-03-16
BR112012003059A2 (pt) 2016-08-02
US8536172B2 (en) 2013-09-17
US20110034470A1 (en) 2011-02-10
AU2010283769B2 (en) 2015-09-17
AR077820A1 (es) 2011-09-28
EP2464640A1 (en) 2012-06-20
KR101506318B1 (ko) 2015-03-26
AU2010283769A1 (en) 2012-02-09
IN2012DN01231A (es) 2015-05-15
IL217756A0 (en) 2012-03-29
CN102471319A (zh) 2012-05-23
WO2011018417A1 (en) 2011-02-17
CN102471319B (zh) 2014-06-18
CA2768749A1 (en) 2011-02-17
JP2013501746A (ja) 2013-01-17
JP5784604B2 (ja) 2015-09-24
SG178321A1 (en) 2012-03-29
KR20120055645A (ko) 2012-05-31

Similar Documents

Publication Publication Date Title
MX348024B (es) Compuestos de adamantilo.
PH12012502212A1 (en) Nitrogen heterocyclic compounds usefulas pde10 inhibitors
MX2009006195A (es) Compuestos basados en 4-fenil-6-(2,2,2-trifluoro-1-feniletoxi)piri midina y metodos de su uso.
MX2011007750A (es) Composiciones y metodos para inhibicion de la ruta jak.
MX2009013353A (es) Compuestos activadores de telomerasa y metodos para su uso.
TW200744586A (en) Therapeutic compounds
MX2009009590A (es) Aminopirimidinas utiles como inhibidores de proteinas cinasas.
TN2010000028A1 (en) Compounds and methods for modulating fxr
TN2011000339A1 (en) Poly (adp-ribose) polymerase (parp) inhibitors
WO2012016186A8 (en) Macrocyclic kinase inhibitors and uses thereof
MX347917B (es) Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso.
IN2012DN03883A (es)
MX367623B (es) 6-amino-nicotinamidas sustituidas como moduladores de kcnq2/3.
MY153057A (en) Tryclic compounds,compositions and methods
MX2020009397A (es) Composiciones y metodos para inhibicion de la via jak.
MX337190B (es) Nuevas bencensulfonamidas como bloqueadores del canal de calcio.
MX337849B (es) Composiciones y metodos para inhibicion de la via jak.
MY167898A (en) Co-crystals and salts of ccr3-inhibitors
IN2012DN03846A (es)
MX2012001449A (es) Inhibidores de cinasas c-jun-n-terminales (jnk).
MX2014000374A (es) Compuesto de aminometil quinolona.
WO2006093547A3 (en) Novel lipoxygenase inhibitors
MX342119B (es) 2-oxi-quinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
MX2013002121A (es) Quinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3.
MX2010008490A (es) Triazolopiridazinas como inhibidores de par1, su produccion y su uso como medicamentos.

Legal Events

Date Code Title Description
FG Grant or registration