[go: up one dir, main page]

MX2011012068A - Nucleosidos 2'-fluoro arabino y su utilizaicon. - Google Patents

Nucleosidos 2'-fluoro arabino y su utilizaicon.

Info

Publication number
MX2011012068A
MX2011012068A MX2011012068A MX2011012068A MX2011012068A MX 2011012068 A MX2011012068 A MX 2011012068A MX 2011012068 A MX2011012068 A MX 2011012068A MX 2011012068 A MX2011012068 A MX 2011012068A MX 2011012068 A MX2011012068 A MX 2011012068A
Authority
MX
Mexico
Prior art keywords
fluoro arabino
arabino nucleosides
nucleosides
fluoro
compounds
Prior art date
Application number
MX2011012068A
Other languages
English (en)
Inventor
Kamal N Tiwari
John A Secrist Iii
Anita T Fowler
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Publication of MX2011012068A publication Critical patent/MX2011012068A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/19—Purine radicals with arabinosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se proporciona un método para el tratamiento del cáncer usando ciertos nucleósidos 2'-fluoro. También se proporciona compuestos representados por la fórmula: (fórmula) en que A es (fórmula); y en que R es alquilo; y sales farmacéuticamente aceptables del mismo; y composiciones farmacéuticas que contienen dichos compuestos.
MX2011012068A 2009-05-12 2010-05-12 Nucleosidos 2'-fluoro arabino y su utilizaicon. MX2011012068A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17743609P 2009-05-12 2009-05-12
PCT/US2010/034463 WO2010132513A1 (en) 2009-05-12 2010-05-12 2'-fluoro arabino nucleosides and use thereof

Publications (1)

Publication Number Publication Date
MX2011012068A true MX2011012068A (es) 2012-06-08

Family

ID=43085308

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011012068A MX2011012068A (es) 2009-05-12 2010-05-12 Nucleosidos 2'-fluoro arabino y su utilizaicon.

Country Status (11)

Country Link
US (1) US20120149657A1 (es)
EP (1) EP2430034A4 (es)
JP (1) JP2012526831A (es)
KR (1) KR20120007077A (es)
CN (1) CN102459297A (es)
AU (1) AU2010249119A1 (es)
BR (1) BRPI1010809A2 (es)
CA (1) CA2761880A1 (es)
EA (1) EA201190269A1 (es)
MX (1) MX2011012068A (es)
WO (1) WO2010132513A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX356509B (es) 2011-12-22 2018-05-30 Alios Biopharma Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos.
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
MA41213A (fr) * 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
JP2020164521A (ja) * 2019-03-29 2020-10-08 国立大学法人 長崎大学 抗ウィルス薬
PE20250684A1 (es) * 2022-03-15 2025-03-04 Rome Therapeutics Inc Compuestos y metodos para el tratamiento de enfermedades

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
EA200700564A1 (ru) * 1998-02-25 2007-08-31 Эмори Юниверсити 2`-фторнуклеозиды
CN101089010B (zh) * 1998-02-25 2011-12-14 埃莫里大学 2＇-氟代核苷
CN100532388C (zh) * 2007-07-16 2009-08-26 郑州大学 2’-氟-4’-取代-核苷类似物、其制备方法及应用

Also Published As

Publication number Publication date
EA201190269A1 (ru) 2012-07-30
WO2010132513A1 (en) 2010-11-18
CA2761880A1 (en) 2010-11-18
AU2010249119A1 (en) 2011-12-01
KR20120007077A (ko) 2012-01-19
BRPI1010809A2 (pt) 2015-10-13
EP2430034A1 (en) 2012-03-21
CN102459297A (zh) 2012-05-16
JP2012526831A (ja) 2012-11-01
US20120149657A1 (en) 2012-06-14
EP2430034A4 (en) 2013-05-15

Similar Documents

Publication Publication Date Title
MX2009006742A (es) Inhibidores acilaminopirazoles como fgfr.
MX2014001595A (es) Compuestos de imidazol, composiciones y metodos de uso.
IN2014MN02106A (es)
TN2011000400A1 (en) Inhibitors of beta-secretase
PH12016502037B1 (en) Certain amino-pyrimidines, compositions thereof, and methods for their use
MX2011011136A (es) Eteres diarilicos.
SG10201806714PA (en) C7-fluoro substituted tetracycline compounds
MX2010006421A (es) Compuestos organicos.
MX2009009238A (es) Nuevos inhibidores de fosfodiesterasa.
TN2015000121A1 (en) Gdf-8 inhibitors
GEP20146146B (en) Pyrrolopyrimidine compounds as inhibitors of cdk4/6
MX2009011816A (es) Derivados de piridina.
TN2012000152A1 (en) Spiropiperidine compounds and pharmaceutical use thereof for treating diabetes
MX2011009796A (es) Inhibidores de la cinasa pi3.
GEP20125487B (en) Organic compounds and their use
UA97351C2 (ru) Производная кумарина, имеющая противоопухолевую активность
GEP20125599B (en) Proteasome inhibitors
MX2009012125A (es) Compuestos terapeuticos.
MX2013003019A (es) Compuestos de azabenzotiazol, composiciones y metodos de uso.
MX2009012613A (es) Tiazoles substituidos por heteroarilo y su uso como agentes antivirales.
MX2012013274A (es) Novedosos derivados de la pirimidina.
IN2012DN02502A (es)
MX2011012068A (es) Nucleosidos 2'-fluoro arabino y su utilizaicon.
MX2013008340A (es) Novedosas 4-amino-n-hidroxi-benzamidas para el tratamiento de cancer.
MX2013002620A (es) Novedosas n-hidroxi-benzamidas para el tratamiento del cancer.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal