MX2011009638A - Derivados de benzotiadiazepinas usados como moduladores de los receptores ampa y nmda. - Google Patents
Derivados de benzotiadiazepinas usados como moduladores de los receptores ampa y nmda.Info
- Publication number
- MX2011009638A MX2011009638A MX2011009638A MX2011009638A MX2011009638A MX 2011009638 A MX2011009638 A MX 2011009638A MX 2011009638 A MX2011009638 A MX 2011009638A MX 2011009638 A MX2011009638 A MX 2011009638A MX 2011009638 A MX2011009638 A MX 2011009638A
- Authority
- MX
- Mexico
- Prior art keywords
- ampa
- grouping
- nmda receptor
- receptor modulators
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos de fórmula (1): (ver fórmula (I)) donde R1 y R2, son idénticos o diferentes, representan cada uno un átomo de hidrógeno o de halógeno, o un grupo alquilo, alcoxi, alquiltio, acilo, alcoxicarbonilo, carboxi, hidroxi, hidroxialquilo, ciano, nitro, amino, aminocarbonilo sustituido o no sustituido, aminosulfonilo, alquilsulfonilaminoalquilo, N-hidroxicarboximidami da o benciloxi, R3 representa un átomo de hidrógeno o un grupo alquilo, cicloalquilo o cicloalquilalquilo, R4 representa un átomo de hidrógeno o un grupo alquilo sustituido o no sustituido; la invención también se refiere al uso de los mismos como moduladores alostéricos positivos de receptores AMPA y agonistas de receptores NMDA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0901300A FR2943342B1 (fr) | 2009-03-20 | 2009-03-20 | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| PCT/FR2010/000227 WO2010106249A1 (fr) | 2009-03-20 | 2010-03-18 | Derives de benzothiadiazepines en tant que modulateures des recepteurs ampa et nmda |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011009638A true MX2011009638A (es) | 2011-09-28 |
Family
ID=40863576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011009638A MX2011009638A (es) | 2009-03-20 | 2010-03-18 | Derivados de benzotiadiazepinas usados como moduladores de los receptores ampa y nmda. |
Country Status (44)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201700456T1 (it) | 2009-07-27 | 2017-11-15 | Gilead Sciences Inc | Composti eterociclici fusi come modulatori dei canali ionici |
| JP5858586B2 (ja) | 2010-07-02 | 2016-02-10 | ギリアード サイエンシーズ， インコーポレイテッド | イオンチャネルモジュレーターとしての縮合複素環式化合物 |
| LT2603513T (lt) | 2010-08-10 | 2020-05-25 | Takeda Pharmaceutical Company Limited | Heterociklinis junginys ir jo panaudojimas kaip ampa receptoriaus teigiamo alosterinio moduliatoriaus |
| LT3400944T (lt) | 2010-11-04 | 2020-09-25 | Albireo Ab | Ibat inhibitoriai, skirt kepenų ligų gydymui |
| TWI577670B (zh) | 2011-05-10 | 2017-04-11 | 基利科學股份有限公司 | 充當離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (es) | 2011-07-01 | 2018-04-28 | ||
| TWI478908B (zh) | 2011-07-01 | 2015-04-01 | Gilead Sciences Inc | 作為離子通道調節劑之稠合雜環化合物 |
| AU2015224425B2 (en) * | 2011-07-01 | 2017-02-09 | Gilead Sciences, Inc. | Fused benzoxazepinones as ion channel modulators |
| JP6134654B2 (ja) | 2012-02-08 | 2017-05-24 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| SMT202300020T1 (it) | 2019-02-06 | 2023-03-17 | Albireo Ab | Composti di benzotiadiazepine e loro uso come modulatori degli acidi biliari |
| PH12022550597A1 (en) | 2019-09-16 | 2024-03-04 | Takeda Pharmaceuticals Co | Azole-fused pyridazin-3(2h)-one derivatives |
| ES2973549T3 (es) | 2019-12-04 | 2024-06-20 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores de los ácidos biliares |
| CN111548325A (zh) * | 2020-05-16 | 2020-08-18 | 西安都创医药科技有限公司 | 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用 |
| CN111620838A (zh) * | 2020-05-16 | 2020-09-04 | 西安都创医药科技有限公司 | 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用 |
| CN111518055A (zh) * | 2020-05-16 | 2020-08-11 | 西安都创医药科技有限公司 | 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用 |
| CN111574475B (zh) * | 2020-06-03 | 2022-09-20 | 西安都创医药科技有限公司 | 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用 |
| KR20230106651A (ko) | 2020-11-12 | 2023-07-13 | 알비레오 에이비 | 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트 |
| CA3198216A1 (en) | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN115368363B (zh) * | 2021-05-17 | 2024-02-20 | 中山大学 | 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用 |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| WO2024240249A1 (zh) * | 2023-05-25 | 2024-11-28 | 正大天晴药业集团股份有限公司 | 一种苯并噻二氮卓化合物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2130096A1 (fr) * | 1992-04-15 | 1993-10-28 | Jean-Claude Aloup | Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant |
| EP1054877A1 (en) * | 1998-02-11 | 2000-11-29 | Du Pont Pharmaceuticals Company | Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors |
| ZA991301B (en) * | 1998-02-18 | 1999-09-13 | Neurosearch As | Glutamate receptor modulators. |
| US6156746A (en) * | 1998-08-25 | 2000-12-05 | Bristol-Myers Squibb Company | 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents |
| GB0209467D0 (en) * | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| DE10300973A1 (de) * | 2003-01-14 | 2004-07-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| FR2877338B1 (fr) * | 2004-11-03 | 2007-01-26 | Servier Lab | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2879201B1 (fr) * | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2009
- 2009-03-20 FR FR0901300A patent/FR2943342B1/fr not_active Expired - Fee Related
-
2010
- 2010-03-02 JO JO201077A patent/JO2780B1/en active
- 2010-03-03 AU AU2010200815A patent/AU2010200815B2/en not_active Ceased
- 2010-03-04 UY UY0001032475A patent/UY32475A/es unknown
- 2010-03-11 TW TW099107121A patent/TWI388326B/zh not_active IP Right Cessation
- 2010-03-17 ZA ZA2010/01905A patent/ZA201001905B/en unknown
- 2010-03-17 SA SA110310217A patent/SA110310217B1/ar unknown
- 2010-03-17 CA CA2696705A patent/CA2696705C/fr not_active Expired - Fee Related
- 2010-03-18 JP JP2012500288A patent/JP5437473B2/ja not_active Expired - Fee Related
- 2010-03-18 AT AT10290141T patent/ATE513822T1/de active
- 2010-03-18 RS RS20110385A patent/RS51919B/sr unknown
- 2010-03-18 DK DK10290141.0T patent/DK2246339T3/da active
- 2010-03-18 KR KR1020117024772A patent/KR101431504B1/ko not_active Expired - Fee Related
- 2010-03-18 WO PCT/FR2010/000227 patent/WO2010106249A1/fr not_active Ceased
- 2010-03-18 PT PT10290141T patent/PT2246339E/pt unknown
- 2010-03-18 PE PE2011001589A patent/PE20120113A1/es not_active Application Discontinuation
- 2010-03-18 ES ES10290141T patent/ES2368691T3/es active Active
- 2010-03-18 BR BRPI1009200A patent/BRPI1009200A2/pt not_active IP Right Cessation
- 2010-03-18 EA EA201101334A patent/EA020259B1/ru not_active IP Right Cessation
- 2010-03-18 MX MX2011009638A patent/MX2011009638A/es active IP Right Grant
- 2010-03-18 EP EP10290141A patent/EP2246339B1/fr active Active
- 2010-03-18 MY MYPI2011004188A patent/MY154001A/en unknown
- 2010-03-18 AP AP2011005935A patent/AP3050A/xx active
- 2010-03-18 PL PL10290141T patent/PL2246339T3/pl unknown
- 2010-03-18 NZ NZ595082A patent/NZ595082A/en not_active IP Right Cessation
- 2010-03-18 MA MA34178A patent/MA33131B1/fr unknown
- 2010-03-18 SG SG2011064367A patent/SG174274A1/en unknown
- 2010-03-18 GE GEAP201012414A patent/GEP20135862B/en unknown
- 2010-03-18 UA UAA201112094A patent/UA100477C2/uk unknown
- 2010-03-18 CN CN201080012931.3A patent/CN102361860B/zh not_active Expired - Fee Related
- 2010-03-18 SI SI201030006T patent/SI2246339T1/sl unknown
- 2010-03-19 AR ARP100100881A patent/AR075892A1/es unknown
- 2010-03-19 US US12/661,598 patent/US8236790B2/en not_active Expired - Fee Related
-
2011
- 2011-08-31 HR HR20110626T patent/HRP20110626T1/hr unknown
- 2011-09-07 CU CU2011000169A patent/CU24030B1/es active IP Right Grant
- 2011-09-07 IL IL215016A patent/IL215016A/en not_active IP Right Cessation
- 2011-09-08 CY CY20111100869T patent/CY1111807T1/el unknown
- 2011-09-12 CR CR20110484A patent/CR20110484A/es unknown
- 2011-09-13 NI NI201100169A patent/NI201100169A/es unknown
- 2011-09-15 CL CL2011002287A patent/CL2011002287A1/es unknown
- 2011-09-19 EC EC2011011340A patent/ECSP11011340A/es unknown
- 2011-09-19 CO CO11121546A patent/CO6361956A2/es active IP Right Grant
- 2011-09-19 TN TN2011000469A patent/TN2011000469A1/fr unknown
- 2011-09-20 HN HN2011002458A patent/HN2011002458A/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2011009638A (es) | Derivados de benzotiadiazepinas usados como moduladores de los receptores ampa y nmda. | |
| GEP20135992B (en) | Sulfonamide derivatives | |
| MX2010008375A (es) | Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3). | |
| MX2013000362A (es) | Derivados de espiro-amina ciclica como moduladores de esfingosina 1 fosfato. | |
| GEP20146124B (en) | Novel ccr2 receptor antagonists and usage thereof | |
| MX2009000884A (es) | Derivados de piridizinona. | |
| MY150062A (en) | Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands | |
| MX2009008921A (es) | Derivados de tiazole en la forma de moduladores de receptores acoplados por proteina g. | |
| MX2010002760A (es) | Derivados de isoquinolinilo e isoindolinilo como antagonistas de la histamina-3. | |
| MX2008013520A (es) | Agonistas del receptor de adenosina a3. | |
| MX2010002899A (es) | Derivados de azaciclilisoquinolinona e isoindolinona como antagonistas de la histamina-3. | |
| UA101172C2 (ru) | Бициклозамещенные пиразолоназопроизводные, способ их получения и фармацевтическое применение | |
| EA201270428A1 (ru) | Замещенные n-фенил-1-(4-пиридинил)-1н-пиразол-3-амины | |
| GEP20125382B (en) | New benzamide derivatives as bradykinin antagonists | |
| EA201200891A1 (ru) | Производные 3,4,4a,10d-тетрагидро-1h-тиопирано[4,3-c]изохинолина | |
| CL2010001639A1 (es) | Proceso para preparacion del hemitartrato de [5-(4,6-dimetil-1h-benzoimidazol-2-il-metil-pirimidin-2-il]-[3-(metil-piperidin-4-il)propil]amina; proceso de recristalizacion del hemitartrato; y hemitaatrato cristalino de [5-(4,6-dimetil-1h-benzoimidazol-2-il)-4-metil- pirimidin-2-il]-[3-(1-metil-piperidin-4-il)-propil]-amina. | |
| EA200700365A1 (ru) | Производные индол-2-карбоксамидина как антагонисты nmda рецептора | |
| CO6531479A2 (es) | Derivados de espirolactama y uso de los mismos | |
| ATE512142T1 (de) | Pyrimidin- und chinazolinderivate als modulatoren der somatostatin-rezeptor aktivität | |
| IL206611A0 (en) | Novel imidazolinylmethyl aryl sulfonamides | |
| WO2010054003A3 (en) | Methylindazole modulators of 5-ht3 receptors | |
| MX2013002892A (es) | Derivados de dihidrobenzoxatiazepinas, preparacion de los mismos, composiciones farmaceuticas y uso como moduladores del receptor ampa. | |
| CY1114196T1 (el) | Αρυλο σουλφοναμιδο αμινοενωσεις και χρηση αυτων ως συνδετων 5-ητ6 | |
| MX2010007928A (es) | Imidazolinilmetil aril sulfonamidas novedosas. | |
| MX2008012824A (es) | Derivados de sulfonil-3-heterociclilindazol como ligandos de 5-hidroxitriptamina-6. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |