MX2010011329A - Analogos de insulina especificos de isoforma. - Google Patents
Analogos de insulina especificos de isoforma.Info
- Publication number
- MX2010011329A MX2010011329A MX2010011329A MX2010011329A MX2010011329A MX 2010011329 A MX2010011329 A MX 2010011329A MX 2010011329 A MX2010011329 A MX 2010011329A MX 2010011329 A MX2010011329 A MX 2010011329A MX 2010011329 A MX2010011329 A MX 2010011329A
- Authority
- MX
- Mexico
- Prior art keywords
- insulin
- analogue
- isoform
- binding
- chain
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 10
- 102000001708 Protein Isoforms Human genes 0.000 title abstract 2
- 108010029485 Protein Isoforms Proteins 0.000 title abstract 2
- 239000004026 insulin derivative Substances 0.000 abstract 5
- 102000004877 Insulin Human genes 0.000 abstract 4
- 108090001061 Insulin Proteins 0.000 abstract 4
- 102000003746 Insulin Receptor Human genes 0.000 abstract 3
- 108010001127 Insulin Receptor Proteins 0.000 abstract 3
- VYXXMAGSIYIYGD-NWAYQTQBSA-N propan-2-yl 2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(pyrimidine-4-carbonylamino)phosphoryl]amino]-2-methylpropanoate Chemical compound CC(C)OC(=O)C(C)(C)NP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)NC(=O)c1ccncn1 VYXXMAGSIYIYGD-NWAYQTQBSA-N 0.000 abstract 3
- 229940125396 insulin Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 abstract 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un método para tratar un mamífero al administrar una cantidad fisiológicamente efectiva de un análogo de insulina o una sal fisiológicamente aceptable del mismo, donde el análogo de insulina exhibe más de dos veces mayor afinidad de enlace a la isoforma de receptor A (IR-A) de insulina que a la isoforma de receptor B (IR-B) de insulina. El análogo de insulina puede ser un análogo de insulina de cadena sencilla o una sal fisiológicamente aceptable del mismo, que contiene una secuencia de cadena A de insulina o un análogo de la misma y una secuencia de cadena B de insulina o un análogo de la misma conectada por un polipéptido de 4-13 aminoácidos. Un análogo de insulina de cadena sencilla puede exhibir mayor enlace de receptor de insulina in vitro a IR-A pero menor enlace a IR-B que la insulina normal mientras que exhibe menor que o igual enlace a IGFR que la insulina normal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4698508P | 2008-04-22 | 2008-04-22 | |
| PCT/US2009/041439 WO2009132129A2 (en) | 2008-04-22 | 2009-04-22 | Isoform-specific insulin analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010011329A true MX2010011329A (es) | 2011-03-15 |
Family
ID=41217411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010011329A MX2010011329A (es) | 2008-04-22 | 2009-04-22 | Analogos de insulina especificos de isoforma. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110195896A1 (es) |
| EP (1) | EP2296692A4 (es) |
| JP (1) | JP2011521621A (es) |
| KR (1) | KR20110021758A (es) |
| CN (1) | CN102065885A (es) |
| AU (1) | AU2009240636A1 (es) |
| BR (1) | BRPI0911571A2 (es) |
| CA (1) | CA2722168A1 (es) |
| MX (1) | MX2010011329A (es) |
| NZ (1) | NZ588857A (es) |
| RU (1) | RU2010147076A (es) |
| WO (1) | WO2009132129A2 (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8343914B2 (en) | 2006-01-06 | 2013-01-01 | Case Western Reserve University | Fibrillation resistant proteins |
| ES2554773T3 (es) | 2006-10-04 | 2015-12-23 | Case Western Reserve University | Insulina y análogos de la insulina resistentes a la fibrilación |
| US8993516B2 (en) | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| US9200053B2 (en) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulin analogues containing penta-fluoro-Phenylalanine at position B24 |
| KR20120129875A (ko) | 2008-07-31 | 2012-11-28 | 케이스 웨스턴 리저브 유니버시티 | 염소화 아미노산을 갖는 인슐린 유사체 |
| WO2010070255A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070252A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| WO2010070253A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| EA020537B1 (ru) | 2008-12-15 | 2014-11-28 | Зилэнд Фарма А/С | Аналоги глюкагона |
| HUE026255T2 (en) | 2009-07-13 | 2016-06-28 | Zealand Pharma As | Acylated glucagon analogues |
| WO2011028813A2 (en) * | 2009-09-01 | 2011-03-10 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
| US8399407B2 (en) | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| CA2783763A1 (en) | 2009-12-11 | 2011-06-16 | Case Western Reserve University | Insulin analogues with chlorinated amino acids |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| AP2013006671A0 (en) | 2010-06-24 | 2013-01-31 | Zealand Pharma As | Glucagon analogues |
| SG192038A1 (en) | 2011-01-20 | 2013-08-30 | Zealand Pharma As | Combination of acylated glucagon analogues with insulin analogues |
| US10995129B2 (en) * | 2011-07-13 | 2021-05-04 | Case Western Reserve University | Non-standard insulin analogues |
| EP2844669B1 (en) | 2012-05-03 | 2018-08-01 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
| SG11201500375PA (en) | 2012-07-23 | 2015-02-27 | Zealand Pharma As | Glucagon analogues |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| CN105008395B (zh) * | 2012-11-05 | 2020-12-29 | 卡斯西部储备大学 | 长效单链胰岛素类似物 |
| JP6735561B2 (ja) | 2012-12-03 | 2020-08-05 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｏ−グリコシル化カルボキシ末端部分（ｃｔｐ）ペプチド系のインスリンおよびインスリン類似体 |
| CN105228643A (zh) * | 2013-03-15 | 2016-01-06 | 卡斯西部储备大学 | 位点2胰岛素类似物 |
| US9884125B2 (en) | 2013-10-04 | 2018-02-06 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| CN119119235A (zh) | 2013-10-17 | 2024-12-13 | 西兰制药公司 | 酰化胰高血糖素类似物 |
| EA035688B1 (ru) | 2013-11-06 | 2020-07-27 | Зилэнд Фарма А/С | Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip |
| EP3065767B1 (en) | 2013-11-06 | 2020-12-30 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
| CN106102763A (zh) | 2014-01-13 | 2016-11-09 | 塞尔玛琳糖尿病有限责任公司 | 速效胰岛素制剂和药物递送系统 |
| KR102569743B1 (ko) * | 2014-10-06 | 2023-08-23 | 케이스 웨스턴 리저브 유니버시티 | 이상 단일 사슬 인슐린 유사체 |
| AU2015340586B2 (en) | 2014-10-29 | 2020-04-30 | Zealand Pharma A/S | GIP agonist compounds and methods |
| SG10201809427SA (en) | 2014-11-21 | 2018-11-29 | Merck Sharp & Dohme | Insulin receptor partial agonists |
| KR20170137198A (ko) | 2015-04-16 | 2017-12-12 | 질랜드 파마 에이/에스 | 아실화된 글루카곤 유사체 |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| UY36870A (es) * | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
| EP3344651B1 (en) | 2015-09-02 | 2022-03-02 | Merck Sharp & Dohme Corp. | A process for obtaining insulin with correctly formed disulfide bonds |
| EP3344278A4 (en) | 2015-09-04 | 2019-01-23 | The California Institute for Biomedical Research | INSULIN-IMMUNOGLOBULIN FUSION PROTEINS |
| HK1255634A1 (zh) * | 2015-12-23 | 2019-08-23 | Case Western Reserve University | 超稳胰岛素类似物在聚合物熔体中的包囊 |
| EP3448417B1 (en) | 2016-04-26 | 2025-11-12 | Merck Sharp & Dohme LLC | Insulin dimer-incretin conjugates |
| US10953076B2 (en) | 2016-05-24 | 2021-03-23 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists and GLP-1 analogues |
| US10689430B2 (en) | 2016-05-25 | 2020-06-23 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
| WO2017210077A1 (en) * | 2016-06-02 | 2017-12-07 | Indiana University Research And Technology Corporation | Single chain insulin prodrugs |
| EP3272877A1 (en) | 2016-07-18 | 2018-01-24 | ETH Zurich | B-cell-mimetic cells |
| SG11201811763SA (en) | 2016-07-18 | 2019-02-27 | Eth Zuerich | B-cell-mimetic cells |
| AU2017361524B2 (en) * | 2016-11-21 | 2022-06-02 | Case Western Reserve University | Rapid-acting insulin analogues of enhanced stability |
| US11041009B2 (en) | 2017-03-23 | 2021-06-22 | Merck Sharp & Dohme Corp. | Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes |
| US12427187B2 (en) | 2019-06-06 | 2025-09-30 | Merck Sharp & Dohme Llc | Glucose-responsive insulin conjugates |
| CN114591417B (zh) * | 2022-04-22 | 2023-04-25 | 四川大学 | 人源单链胰岛素类似物及其应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| EP0425482B1 (en) * | 1988-07-20 | 1993-08-18 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
| US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| DE3936876A1 (de) * | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| CZ342492A3 (en) * | 1991-11-26 | 1993-06-16 | Lilly Co Eli | Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised |
| US6011007A (en) * | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| US20030104981A1 (en) * | 1995-11-03 | 2003-06-05 | Jelena Mandic | Human insulin analogues |
| DE19652713C2 (de) * | 1996-12-18 | 2001-11-22 | Aventis Pharma Gmbh | Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher |
| DE19726167B4 (de) * | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| CA2306905A1 (en) * | 1997-10-24 | 1999-05-06 | Eli Lilly And Company | Fatty acid-acylated insulin analogs |
| CO4970787A1 (es) * | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| US7449443B2 (en) * | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| US7316999B2 (en) * | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
| KR100449454B1 (ko) * | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| WO2003053460A1 (en) * | 2001-12-19 | 2003-07-03 | Eli Lilly And Company | Crystalline compositions for controlling blood glucose |
| BR0215029A (pt) * | 2001-12-20 | 2005-12-20 | Lilly Co Eli | Molécula de insulina, uso da mesma, composição, uso desta, microcristal, processo para prepará-lo, uso deste, e, métodos para preparar uma molécula de insulina, para tratar hiperglicemia, e para tratar diabetes mellitus |
| US7129211B2 (en) * | 2002-03-26 | 2006-10-31 | Council Of Scientific And Industrial Research | Adipocyte Insulin adpinsl with Insulin A and B chains and an effective method of treating type 2 diabetes in a subject using adipocyte insulin |
| EP1523326A4 (en) * | 2002-05-06 | 2009-09-09 | Univ Jefferson | INSULIN-ASSOCIATED PEPTIDES FOR IMPROVING BRAIN EFFECT |
| BRPI0409600A (pt) * | 2003-04-29 | 2006-04-18 | Lilly Co Eli | análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina |
| AR044803A1 (es) * | 2003-06-17 | 2005-10-05 | Sembiosys Genetics Inc | Metodos para la produccion de insulina |
| AU2004295023A1 (en) * | 2003-12-03 | 2005-06-16 | Novo Nordisk A/S | Single-chain insulin |
| US8343914B2 (en) * | 2006-01-06 | 2013-01-01 | Case Western Reserve University | Fibrillation resistant proteins |
| ES2554773T3 (es) * | 2006-10-04 | 2015-12-23 | Case Western Reserve University | Insulina y análogos de la insulina resistentes a la fibrilación |
| US7790677B2 (en) * | 2006-12-13 | 2010-09-07 | Elona Biotechnologies | Insulin production methods and pro-insulin constructs |
| MY152979A (en) * | 2008-01-09 | 2014-12-15 | Sanofi Aventis Deutschland | Novel insulin derivatives having an extremely delayed time-action profile |
| US8993516B2 (en) * | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| KR20120129875A (ko) * | 2008-07-31 | 2012-11-28 | 케이스 웨스턴 리저브 유니버시티 | 염소화 아미노산을 갖는 인슐린 유사체 |
| US8399407B2 (en) * | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| US20110103575A1 (en) * | 2009-10-30 | 2011-05-05 | Telect Inc. | High-density splitter/patch telecommunications system |
-
2009
- 2009-04-22 CA CA2722168A patent/CA2722168A1/en not_active Abandoned
- 2009-04-22 US US12/989,399 patent/US20110195896A1/en not_active Abandoned
- 2009-04-22 BR BRPI0911571A patent/BRPI0911571A2/pt not_active IP Right Cessation
- 2009-04-22 JP JP2011506432A patent/JP2011521621A/ja active Pending
- 2009-04-22 EP EP09734135A patent/EP2296692A4/en not_active Withdrawn
- 2009-04-22 RU RU2010147076/10A patent/RU2010147076A/ru not_active Application Discontinuation
- 2009-04-22 AU AU2009240636A patent/AU2009240636A1/en not_active Abandoned
- 2009-04-22 MX MX2010011329A patent/MX2010011329A/es not_active Application Discontinuation
- 2009-04-22 CN CN2009801244782A patent/CN102065885A/zh active Pending
- 2009-04-22 WO PCT/US2009/041439 patent/WO2009132129A2/en not_active Ceased
- 2009-04-22 KR KR1020107025017A patent/KR20110021758A/ko not_active Withdrawn
- 2009-04-22 NZ NZ588857A patent/NZ588857A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2296692A2 (en) | 2011-03-23 |
| BRPI0911571A2 (pt) | 2018-04-03 |
| KR20110021758A (ko) | 2011-03-04 |
| CN102065885A (zh) | 2011-05-18 |
| US20110195896A1 (en) | 2011-08-11 |
| NZ588857A (en) | 2012-07-27 |
| WO2009132129A3 (en) | 2010-01-21 |
| WO2009132129A2 (en) | 2009-10-29 |
| RU2010147076A (ru) | 2012-05-27 |
| CA2722168A1 (en) | 2009-10-29 |
| AU2009240636A1 (en) | 2009-10-29 |
| JP2011521621A (ja) | 2011-07-28 |
| EP2296692A4 (en) | 2012-06-06 |
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