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MX2010008400A - Derivado de piperidina. - Google Patents

Derivado de piperidina.

Info

Publication number
MX2010008400A
MX2010008400A MX2010008400A MX2010008400A MX2010008400A MX 2010008400 A MX2010008400 A MX 2010008400A MX 2010008400 A MX2010008400 A MX 2010008400A MX 2010008400 A MX2010008400 A MX 2010008400A MX 2010008400 A MX2010008400 A MX 2010008400A
Authority
MX
Mexico
Prior art keywords
piperidine derivative
compound
system including
side effects
adverse side
Prior art date
Application number
MX2010008400A
Other languages
English (en)
Inventor
Kunihiko Higashiura
Takashi Ogino
Taizo Ito
Hiroyuki Iwatsuki
Original Assignee
Nippon Zoki Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zoki Pharmaceutical Co filed Critical Nippon Zoki Pharmaceutical Co
Publication of MX2010008400A publication Critical patent/MX2010008400A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención proporciona un compuesto de derivado de piperidina que tiene excelente acción antagónica del receptor de histamina, el cual es útil como ingrediente activo de una composición farmacéutica, especialmente una antihistamina. El derivado de piperidina de la presente invención tiene una potente acción antagonista del receptor de histamina. Además, el compuesto de la presente invención muestra baja transferencia en el cerebro aun en una prueba de enlace del receptor cerebral donde a un ratón se le administra por la ruta oral el compuesto, de modo que el compuesto tiene propiedades preferidas para aliviar los efectos colaterales en el sistema nervioso central, tal como el adormecimiento. El derivado de piperidina de la presente invención es muy útil como una antihistamina novedosa que tiene efectos colaterales menores en el sistema nervioso central, tal como el adormecimiento.
MX2010008400A 2008-01-30 2008-11-20 Derivado de piperidina. MX2010008400A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008019121 2008-01-30
PCT/JP2008/071097 WO2009096080A1 (ja) 2008-01-30 2008-11-20 ピペリジン誘導体

Publications (1)

Publication Number Publication Date
MX2010008400A true MX2010008400A (es) 2010-08-23

Family

ID=40912442

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008400A MX2010008400A (es) 2008-01-30 2008-11-20 Derivado de piperidina.

Country Status (16)

Country Link
US (1) US8377967B2 (es)
EP (1) EP2243778B1 (es)
JP (1) JP5096500B2 (es)
KR (1) KR101379783B1 (es)
CN (1) CN101932575B (es)
AU (1) AU2008349239B2 (es)
BR (1) BRPI0821909A2 (es)
CA (1) CA2713293A1 (es)
DK (1) DK2243778T3 (es)
ES (1) ES2527588T3 (es)
IL (1) IL207315A (es)
MX (1) MX2010008400A (es)
NZ (1) NZ587050A (es)
RU (1) RU2475485C2 (es)
TW (1) TWI429641B (es)
WO (1) WO2009096080A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2732282C (en) * 2008-08-01 2016-03-29 Nippon Zoki Pharmaceutical Co., Ltd. Aminopropylidene derivative
JP5083989B2 (ja) * 2008-11-20 2012-11-28 日本臓器製薬株式会社 ピペリジン誘導体を含有する医薬
JP5606440B2 (ja) * 2009-07-28 2014-10-15 日本臓器製薬株式会社 チアベンゾアズレンプロピオン酸誘導体の製造法
JP5460620B2 (ja) * 2010-01-29 2014-04-02 日本臓器製薬株式会社 アミノプロピリデン誘導体を含有する医薬
CN113880808B (zh) * 2020-07-03 2024-12-31 合肥医工医药股份有限公司 一类三唑类化合物、制备方法及其医药用途
CN119241534B (zh) * 2024-09-18 2025-12-05 武汉九州钰民医药科技有限公司 一种恩塞芬汀的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1437412A (fr) 1963-12-19 1966-05-06 Sandoz Sa Nouveaux benzo-cyclohepta-thiophènes et leur préparation
US3491103A (en) 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
US3464983A (en) 1964-02-04 1969-09-02 Sandoz Ag 4h-benzo(4,5)cyclohepta(1,2-b)thiophenes
FR1502857A (fr) 1965-10-01 1967-11-24 Sandoz Sa Nouveaux dérivés du benzo-cyclohepta-thiophène et leur préparation
DK127072A (es) * 1967-02-17
CH531000A (de) 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene
SU512711A3 (ru) 1970-03-11 1976-04-30 Сандос Аг (Фирма) Способ получени производных бензо-(4,5)-циклогепта (1,2-в) -тиофена
IL37621A (en) 1970-09-24 1975-05-22 Sandoz Ag Benzocycloheptathiophene derivatives,their preparation and pharmaceutical compositions containing them
US3960894A (en) * 1972-01-24 1976-06-01 Sandoz Ltd. 9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones
BE794377A (fr) 1972-01-24 1973-07-23 Sandoz Sa Nouveaux derives du benzo-cyclohepta-thiophene
CH568312A5 (es) 1972-01-24 1975-10-31 Sandoz Ag
SE388858B (sv) * 1972-09-20 1976-10-18 Sandoz Ag Analogiforfarande for framstellning av nya 2-alkyl-4(1-alkyl-4-piperidyliden)bensocykloheptatiofenderivat
DE2605980A1 (de) 1975-02-26 1976-09-09 Sandoz Ag Neue benzocycloheptathiophenderivate, ihre herstellung und verwendung
DE2626583A1 (de) 1975-06-24 1977-01-13 Sandoz Ag Neue benzocycloheptathiophenderivate ihre herstellung und ihre verwendung als heilmittel
ATE13297T1 (de) 1980-09-02 1985-06-15 Sandoz Ag Piperidyliden-derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
JPS5760351A (en) 1980-09-29 1982-04-12 Mitsubishi Electric Corp Multicolor picture forming apparatus by electrostatic recording system
FR2620121B1 (fr) 1987-09-09 1990-01-05 Synthelabo ((pyrimidinyl-2)-aminoalkyl)-1 piperidines, leur preparation et leur application en therapeutique
EP0412988A1 (en) 1988-04-28 1991-02-20 Schering Corporation Fused polycyclic compounds, compositions, methods of manufacture and their use as paf antagonists, antihistamines and/or antiinflammatory agents
CA2038417A1 (en) 1990-04-11 1991-10-12 Yasuo Ito Piperidine compounds, method for preparation thereof, and a pharmaceutical composition comprising the same
JPH03294277A (ja) 1990-04-11 1991-12-25 Hokuriku Seiyaku Co Ltd ピペリジン誘導体
GB9102997D0 (en) 1991-02-13 1991-03-27 Pfizer Ltd Therapeutic agents
KR20010005791A (ko) 1997-04-03 2001-01-15 아베르그, 에이. 케이 벤조시클로헵타티오펜 화합물
RU2279428C2 (ru) * 2000-09-18 2006-07-10 Эйсай Ко., Лтд. Производные пиридазинона и триазинона и их применение в качестве фармацевтических препаратов
AU2004253898A1 (en) 2003-06-27 2005-01-13 Janssen Pharmaceutica N.V. Tricyclic delta opioid modulators

Also Published As

Publication number Publication date
EP2243778A4 (en) 2011-06-08
US20100331365A1 (en) 2010-12-30
BRPI0821909A2 (pt) 2018-07-17
EP2243778A1 (en) 2010-10-27
WO2009096080A1 (ja) 2009-08-06
AU2008349239A1 (en) 2009-08-06
RU2475485C2 (ru) 2013-02-20
KR20100114525A (ko) 2010-10-25
ES2527588T3 (es) 2015-01-27
RU2010136055A (ru) 2012-03-10
JPWO2009096080A1 (ja) 2011-05-26
CN101932575B (zh) 2013-06-12
JP5096500B2 (ja) 2012-12-12
NZ587050A (en) 2012-08-31
TW200932741A (en) 2009-08-01
DK2243778T3 (en) 2014-11-17
EP2243778B1 (en) 2014-10-29
IL207315A (en) 2014-05-28
KR101379783B1 (ko) 2014-03-31
AU2008349239B2 (en) 2012-12-06
US8377967B2 (en) 2013-02-19
CA2713293A1 (en) 2009-08-06
IL207315A0 (en) 2010-12-30
HK1152525A1 (en) 2012-03-02
TWI429641B (zh) 2014-03-11
CN101932575A (zh) 2010-12-29

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