MX2010002679A - Derivados de 4-oxoquinolina deuterados para el tratamiento de la infeccion por el virus de inmunodeficiencia humana. - Google Patents
Derivados de 4-oxoquinolina deuterados para el tratamiento de la infeccion por el virus de inmunodeficiencia humana.Info
- Publication number
- MX2010002679A MX2010002679A MX2010002679A MX2010002679A MX2010002679A MX 2010002679 A MX2010002679 A MX 2010002679A MX 2010002679 A MX2010002679 A MX 2010002679A MX 2010002679 A MX2010002679 A MX 2010002679A MX 2010002679 A MX2010002679 A MX 2010002679A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- deuterated
- treatment
- hiv infection
- oxoquinoline
- Prior art date
Links
- HETSDWRDICBRSQ-UHFFFAOYSA-N 3h-quinolin-4-one Chemical class C1=CC=C2C(=O)CC=NC2=C1 HETSDWRDICBRSQ-UHFFFAOYSA-N 0.000 title abstract 3
- 208000031886 HIV Infections Diseases 0.000 title 1
- 208000037357 HIV infectious disease Diseases 0.000 title 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- JUZYLCPPVHEVSV-LJQANCHMSA-N elvitegravir Chemical class COC1=CC=2N([C@H](CO)C(C)C)C=C(C(O)=O)C(=O)C=2C=C1CC1=CC=CC(Cl)=C1F JUZYLCPPVHEVSV-LJQANCHMSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229940099797 HIV integrase inhibitor Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960003586 elvitegravir Drugs 0.000 abstract 1
- 239000003084 hiv integrase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos novedosos que son derivados de 4-axoquinolina y a las sales de los mismos farmacéuticamente aceptables. Más específicamente, esta invención se refiere a nuevos derivados de 4-axoquinolina que son derivados de elvitegravir. Esta invención también proporciona composiciones libres de pirógenos que comprenden uno o más compuestos de la invención y un portador, y al uso de los compuestos y composiciones descritos en los métodos de tratamiento de las enfermedades y afecciones que son tratadas benéficamente por la administración de un inhibidor de la integrasa de VIH, tal como elvitegravir.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99342807P | 2007-09-12 | 2007-09-12 | |
| PCT/US2008/010662 WO2009035662A1 (en) | 2007-09-12 | 2008-09-12 | Deuterated 4 -oxoquinoline derivatives for the treatment of hiv infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002679A true MX2010002679A (es) | 2010-03-29 |
Family
ID=40070844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002679A MX2010002679A (es) | 2007-09-12 | 2008-09-12 | Derivados de 4-oxoquinolina deuterados para el tratamiento de la infeccion por el virus de inmunodeficiencia humana. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7994194B2 (es) |
| EP (1) | EP2197847B1 (es) |
| AU (1) | AU2008299931B2 (es) |
| CA (1) | CA2698825C (es) |
| ES (1) | ES2406479T3 (es) |
| MX (1) | MX2010002679A (es) |
| WO (1) | WO2009035662A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1564210T1 (sl) * | 2002-11-20 | 2010-01-29 | Japan Tobacco Inc | 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze |
| WO2009035662A1 (en) | 2007-09-12 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated 4 -oxoquinoline derivatives for the treatment of hiv infection |
| US8809583B2 (en) | 2010-01-08 | 2014-08-19 | Amyris, Inc. | Methods for producing isomers of muconic acid and muconate salts |
| CN103819402B (zh) * | 2012-11-17 | 2016-03-30 | 上海迪赛诺化学制药有限公司 | 埃替拉韦中间体及其制备方法和应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704035A (en) * | 1986-10-06 | 1987-11-03 | Baker Perkins, Inc. | Remotely transmitting batch mixer |
| US4962495A (en) * | 1988-10-03 | 1990-10-09 | Lucas Aerospace Power Transmission Corp. | Apparatus and method for transmitting condition data from a rotating member to a stationary device |
| CA2186371A1 (en) | 1994-03-25 | 1995-10-05 | Robert T. Foster | Enhancement of the efficacy of dihydropyridines by deuteration |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| FR2753648B1 (fr) * | 1996-09-26 | 1998-11-27 | Alphacan Sa | Procede et installation de fabrication de tubes en matiere plastique avec etirage bi-axial, et tube en matiere plastique ainsi obtenu |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| PT1104760E (pt) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| SI1564210T1 (sl) | 2002-11-20 | 2010-01-29 | Japan Tobacco Inc | 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze |
| WO2005113509A1 (en) | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| US8633219B2 (en) | 2004-05-21 | 2014-01-21 | Japan Tobacco Inc. | Combination therapy |
| US20060058286A1 (en) * | 2004-09-16 | 2006-03-16 | Mark Krystal | Methods of treating HIV infection |
| CN101309917B (zh) | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 |
| JP2009525261A (ja) | 2006-02-01 | 2009-07-09 | 日本たばこ産業株式会社 | レトロウイルス感染症の治療のための、６−（３−クロロ−２−フルオロベンジル）−１−［（２ｓ）−１−ヒドロキシ−３−メチルブタン−２−イル］−７−メトキシ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸またはその塩の使用 |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| CA2661404A1 (en) | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| WO2009035662A1 (en) | 2007-09-12 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated 4 -oxoquinoline derivatives for the treatment of hiv infection |
-
2008
- 2008-09-12 WO PCT/US2008/010662 patent/WO2009035662A1/en not_active Ceased
- 2008-09-12 US US12/283,620 patent/US7994194B2/en active Active
- 2008-09-12 MX MX2010002679A patent/MX2010002679A/es active IP Right Grant
- 2008-09-12 AU AU2008299931A patent/AU2008299931B2/en not_active Ceased
- 2008-09-12 CA CA2698825A patent/CA2698825C/en not_active Expired - Fee Related
- 2008-09-12 EP EP08830735A patent/EP2197847B1/en not_active Not-in-force
- 2008-09-12 ES ES08830735T patent/ES2406479T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20090143427A1 (en) | 2009-06-04 |
| AU2008299931B2 (en) | 2013-01-10 |
| EP2197847B1 (en) | 2012-11-07 |
| US7994194B2 (en) | 2011-08-09 |
| CA2698825A1 (en) | 2009-03-19 |
| EP2197847A1 (en) | 2010-06-23 |
| WO2009035662A1 (en) | 2009-03-19 |
| ES2406479T3 (es) | 2013-06-07 |
| AU2008299931A1 (en) | 2009-03-19 |
| CA2698825C (en) | 2013-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |