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MX2010002642A - Proceso para la elaboracion de intermediarios monobactamicos puenteados. - Google Patents

Proceso para la elaboracion de intermediarios monobactamicos puenteados.

Info

Publication number
MX2010002642A
MX2010002642A MX2010002642A MX2010002642A MX2010002642A MX 2010002642 A MX2010002642 A MX 2010002642A MX 2010002642 A MX2010002642 A MX 2010002642A MX 2010002642 A MX2010002642 A MX 2010002642A MX 2010002642 A MX2010002642 A MX 2010002642A
Authority
MX
Mexico
Prior art keywords
sub
unsubstituted
formula
substituted
group
Prior art date
Application number
MX2010002642A
Other languages
English (en)
Inventor
Lin Xu
Marc Muller
Xiaoping Wu
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of MX2010002642A publication Critical patent/MX2010002642A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un proceso para elaborar un compuesto de Fórmula (I) el cual tiene conformación cis y en donde R1 representa un grupo 1-fenil-alquiloC1-C4 o 1-naftil-alquiloC1-C4, en donde la porción fenilo o naftilo de R1 es no sustituida o sustituida con uno o más grupos alcoxi C1-C4 y los átomos de carbono en la posición 2-, 3- y/o 4- de la parte alquilo de R1 son, independientemente de la porción fenilo o naftilo de R1 e independientemente uno del otro, no sustituidos o sustituidos con alcoxi C1-C4 y/o sililoxi o, preferiblemente, son no sustituidos o sustituidos con un grupo alcoxi C1-C4 y/o grupo sililoxi por átomo de carbono, y R2 representa un grupo alquilo C1-C6 o un grupo bencilo no sustituido o sustituido, en el proceso un compuesto de Fórmula (II) en donde R3 representa un grupo alquilo C1-C6 o un grupo bencilo no sustituido o sustituido, y R1 y R2 tienen el mismo significado que en la fórmula (I); es tratado con una base a una temperatura de 0° C o menor en un solvente líquido aprótico durante un período de tiempo suficiente para obtener el compuesto de la fórmula (I).
MX2010002642A 2007-09-17 2008-09-15 Proceso para la elaboracion de intermediarios monobactamicos puenteados. MX2010002642A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07116603 2007-09-17
PCT/EP2008/062258 WO2009037229A1 (en) 2007-09-17 2008-09-15 Process for the manufacture of bridged monobactam intermediates

Publications (1)

Publication Number Publication Date
MX2010002642A true MX2010002642A (es) 2010-03-26

Family

ID=39027525

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002642A MX2010002642A (es) 2007-09-17 2008-09-15 Proceso para la elaboracion de intermediarios monobactamicos puenteados.

Country Status (16)

Country Link
US (2) US8450477B2 (es)
EP (1) EP2197881B1 (es)
JP (1) JP5551072B2 (es)
KR (1) KR101421774B1 (es)
CN (1) CN101801974B (es)
AU (1) AU2008300616B2 (es)
BR (1) BRPI0816909A2 (es)
CA (1) CA2698441C (es)
CY (1) CY1114147T1 (es)
DK (1) DK2197881T3 (es)
ES (1) ES2419255T3 (es)
MX (1) MX2010002642A (es)
PL (1) PL2197881T3 (es)
PT (1) PT2197881E (es)
WO (1) WO2009037229A1 (es)
ZA (1) ZA201001694B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014184503A1 (fr) 2013-05-16 2014-11-20 Universite De Strasbourg Composés dendritiques comprenant un agent chélatant, fluorochrome ou agent de reconnaissance, compositions les comprenant et leurs utilisations
CN103554112B (zh) * 2013-11-07 2016-04-13 中国科学院昆明植物研究所 顺式稠环的β-内酰胺化合物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA826089B (en) * 1981-08-27 1983-07-27 Hoffmann La Roche Beta-lactams
CA1262128A (en) * 1981-08-27 1989-10-03 Christian N. Hubschwerlen .beta.-lactams
DK0508234T3 (da) * 1991-04-11 1996-10-28 Hoffmann La Roche Beta-lactamer
CA2143519A1 (en) * 1994-03-11 1995-09-12 Markus Bohringer Beta-lactams
TW358097B (en) * 1996-05-24 1999-05-11 Hoffmann La Roche Beta-lactams and their process and pharmaceutical compositions
CN103724330B (zh) 2005-12-07 2015-08-19 巴斯利尔药物股份公司 单环-内酰胺类抗生素与β-内酰胺酶抑制剂的有效的联合应用

Also Published As

Publication number Publication date
US20130274503A1 (en) 2013-10-17
JP2010539211A (ja) 2010-12-16
WO2009037229A1 (en) 2009-03-26
KR20100074157A (ko) 2010-07-01
CA2698441C (en) 2012-04-03
CN101801974A (zh) 2010-08-11
DK2197881T3 (da) 2013-06-24
JP5551072B2 (ja) 2014-07-16
EP2197881A1 (en) 2010-06-23
CA2698441A1 (en) 2009-03-26
HK1142900A1 (en) 2010-12-17
US20110178291A1 (en) 2011-07-21
PT2197881E (pt) 2013-06-28
US8877961B2 (en) 2014-11-04
AU2008300616B2 (en) 2013-02-14
AU2008300616A1 (en) 2009-03-26
CY1114147T1 (el) 2016-07-27
KR101421774B1 (ko) 2014-07-30
EP2197881B1 (en) 2013-04-17
US8450477B2 (en) 2013-05-28
PL2197881T3 (pl) 2013-09-30
CN101801974B (zh) 2013-08-28
BRPI0816909A2 (pt) 2015-03-17
ZA201001694B (en) 2010-10-27
ES2419255T3 (es) 2013-08-20

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