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MX2010001602A - "compuestos de 2-(2-oxoindolin-3-iliden)metil-5-(2-hidroxi-3-morfo lin-4-il-propil)-6,7-dihidro-1h-pirrol[3,2-c]pirridin-4(5h)-ona y su uso como inhibidores de proteína quinasa". - Google Patents

"compuestos de 2-(2-oxoindolin-3-iliden)metil-5-(2-hidroxi-3-morfo lin-4-il-propil)-6,7-dihidro-1h-pirrol[3,2-c]pirridin-4(5h)-ona y su uso como inhibidores de proteína quinasa".

Info

Publication number
MX2010001602A
MX2010001602A MX2010001602A MX2010001602A MX2010001602A MX 2010001602 A MX2010001602 A MX 2010001602A MX 2010001602 A MX2010001602 A MX 2010001602A MX 2010001602 A MX2010001602 A MX 2010001602A MX 2010001602 A MX2010001602 A MX 2010001602A
Authority
MX
Mexico
Prior art keywords
pyridine
compounds
oxoindoline
ylidene
pyrrol
Prior art date
Application number
MX2010001602A
Other languages
English (en)
Inventor
Yidong Su
Peng Cho Tang
Jialiang Yang
Fuqiang Zhao
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2010001602A publication Critical patent/MX2010001602A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos pirrolo[3, 2-c]piridin-4-ona-2-indolinona, en especial compuestos 2-(2-oxoindolin-3-iliden)metil-5-(2-hidroxi-3-morfolin- 4-il-propil)-6,7-dihidro-1H-pirrol[3,2-c]piridina-4(5H)-ona. Su preparación y composición farmacéutica y uso farmacéutico como inhibidores de proteína quinasa. (Ver Fórmula I).
MX2010001602A 2007-08-15 2008-07-29 "compuestos de 2-(2-oxoindolin-3-iliden)metil-5-(2-hidroxi-3-morfo lin-4-il-propil)-6,7-dihidro-1h-pirrol[3,2-c]pirridin-4(5h)-ona y su uso como inhibidores de proteína quinasa". MX2010001602A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2007101418749A CN101367801B (zh) 2007-08-15 2007-08-15 吡咯并六元n杂环羟基吗啡啉类衍生物的制备方法及其在医药上的应用
PCT/CN2008/001388 WO2009024016A1 (en) 2007-08-15 2008-07-29 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl -propyl)-6,7-dihydro -1h- pyrrol[3,2-c]pyridine-4(5h)-one compounds and use as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2010001602A true MX2010001602A (es) 2010-03-15

Family

ID=40377816

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001602A MX2010001602A (es) 2007-08-15 2008-07-29 "compuestos de 2-(2-oxoindolin-3-iliden)metil-5-(2-hidroxi-3-morfo lin-4-il-propil)-6,7-dihidro-1h-pirrol[3,2-c]pirridin-4(5h)-ona y su uso como inhibidores de proteína quinasa".

Country Status (14)

Country Link
US (1) US8299069B2 (es)
EP (1) EP2179998B1 (es)
JP (1) JP2010535819A (es)
KR (1) KR20100059869A (es)
CN (1) CN101367801B (es)
AU (1) AU2008288615B2 (es)
BR (1) BRPI0815358A2 (es)
CA (1) CA2694380A1 (es)
MX (1) MX2010001602A (es)
RU (1) RU2472792C2 (es)
TW (1) TW201000100A (es)
UA (1) UA98797C2 (es)
WO (1) WO2009024016A1 (es)
ZA (1) ZA201000627B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0707312B1 (pt) 2006-01-27 2022-06-07 Shanghai Hengrui Pharmacetical Co., Ltd Inibidores de pirrolo [3,2-c] piridina-4-ona 2-indolinona proteína cinase, seu uso e seu processo de fabricação, intermediário e seus processos de fabricação, composição farmacêutica e seu uso
US8697697B2 (en) 2011-01-04 2014-04-15 Kinentia Biosciences Llc Pyrazole derivatives as ERK inhibitors
CN104109160B (zh) * 2013-04-17 2017-12-15 上海翰森生物医药科技有限公司 吡咯并n杂环类化合物及其制备方法和医药用途
CN106565585A (zh) * 2016-10-13 2017-04-19 云南大学 一种n‑取代亚苄基吡咯烷二酮及其制备方法和用途
CN114057735B (zh) * 2020-08-03 2024-02-20 江苏恒瑞医药股份有限公司 一种多靶点酪氨酸激酶抑制剂的新晶型及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423997D0 (en) * 1994-11-28 1995-01-11 Erba Carlo Spa Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
DE60111358T2 (de) * 2000-02-28 2006-05-11 Sugen, Inc., San Diego 3-(pyrolyllacton)-2-indolinon verbindungen zur verwendung als kinase-hemmstoffe
EP1294688A2 (en) 2000-06-02 2003-03-26 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
CA2414468A1 (en) * 2000-06-30 2002-01-10 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
US20050090498A1 (en) * 2001-05-24 2005-04-28 Kiyohiro Samizu 3-Quinolin-2(1h)-ylideneindolin-2-one derivative
US20040209937A1 (en) 2003-02-24 2004-10-21 Sugen, Inc. Treatment of excessive osteolysis with indolinone compounds
CN101007815B (zh) * 2006-01-27 2010-06-23 江苏恒瑞医药股份有限公司 吡咯并六元杂环化合物及其在医药上的用途
BRPI0707312B1 (pt) * 2006-01-27 2022-06-07 Shanghai Hengrui Pharmacetical Co., Ltd Inibidores de pirrolo [3,2-c] piridina-4-ona 2-indolinona proteína cinase, seu uso e seu processo de fabricação, intermediário e seus processos de fabricação, composição farmacêutica e seu uso
CN101007814A (zh) * 2006-01-27 2007-08-01 上海恒瑞医药有限公司 吡咯并六元杂环化合物及其在医药上的用途
RU2302417C1 (ru) * 2006-03-14 2007-07-10 Иващенко Андрей Александрович 1-оксо-3-(1н-индол-3-ил)-1,2,3,4-тетрагидроизохинолины, способы их получения, комбинаторная библиотека и фокусированная библиотека

Also Published As

Publication number Publication date
UA98797C2 (en) 2012-06-25
CA2694380A1 (en) 2009-02-26
RU2010104752A (ru) 2011-09-20
EP2179998A4 (en) 2010-07-28
AU2008288615A1 (en) 2009-02-26
ZA201000627B (en) 2011-04-28
RU2472792C2 (ru) 2013-01-20
US8299069B2 (en) 2012-10-30
KR20100059869A (ko) 2010-06-04
BRPI0815358A2 (pt) 2015-02-10
AU2008288615B2 (en) 2013-01-10
CN101367801A (zh) 2009-02-18
US20100160317A1 (en) 2010-06-24
JP2010535819A (ja) 2010-11-25
EP2179998B1 (en) 2012-08-29
WO2009024016A1 (en) 2009-02-26
EP2179998A1 (en) 2010-04-28
TW201000100A (en) 2010-01-01
CN101367801B (zh) 2011-01-12

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