MX2010000385A - Clon celular para producir la fsh. - Google Patents
Clon celular para producir la fsh.Info
- Publication number
- MX2010000385A MX2010000385A MX2010000385A MX2010000385A MX2010000385A MX 2010000385 A MX2010000385 A MX 2010000385A MX 2010000385 A MX2010000385 A MX 2010000385A MX 2010000385 A MX2010000385 A MX 2010000385A MX 2010000385 A MX2010000385 A MX 2010000385A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- present
- fsh
- recombinant
- relates
- Prior art date
Links
- 210000004368 gonadotroph Anatomy 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 6
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 102000003864 Human Follicle Stimulating Hormone Human genes 0.000 abstract 3
- 108010082302 Human Follicle Stimulating Hormone Proteins 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 108700010070 Codon Usage Proteins 0.000 abstract 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 abstract 1
- 229940028334 follicle stimulating hormone Drugs 0.000 abstract 1
- 238000004114 suspension culture Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se relaciona con moléculas de ácido nucleico que comprenden una secuencia de ácido nucleico que codifica para la cadena a y ß de la hormona humana estimuladora de folículos (FSH), respectivamente, que se ha modificado con respecto al tratamiento de codones en células CHO. La presente invención se relaciona además con una molécula de ácido nucleico recombinante que comprende estas secuencias de ácido nucleico y las células hospederas que contienen estas moléculas de ácido nucleico recombinante, así como también su uso en la producción de la FSH humana recombinante. Por último la presente invención también se relaciona con un método para producir células hospederas que expresan la hormona humana estimuladora de folículos al transfectar células en cultivo en suspensión bajo condiciones sin suero con la molécula de ácido nucleico recombinante de la presente invención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07111257 | 2007-06-28 | ||
| PCT/EP2008/058274 WO2009000913A1 (en) | 2007-06-28 | 2008-06-27 | Fsh producing cell clone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010000385A true MX2010000385A (es) | 2010-03-29 |
Family
ID=39745099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010000385A MX2010000385A (es) | 2007-06-28 | 2008-06-27 | Clon celular para producir la fsh. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8318457B2 (es) |
| EP (2) | EP2492280A1 (es) |
| JP (1) | JP5570980B2 (es) |
| KR (1) | KR101522217B1 (es) |
| CN (1) | CN101720332B (es) |
| AU (1) | AU2008267138B9 (es) |
| BR (1) | BRPI0813913B1 (es) |
| CA (1) | CA2690844C (es) |
| CY (1) | CY1114463T1 (es) |
| DK (1) | DK2170942T3 (es) |
| EA (1) | EA022993B1 (es) |
| ES (1) | ES2432183T3 (es) |
| HR (1) | HRP20130921T1 (es) |
| IL (1) | IL202280A (es) |
| MX (1) | MX2010000385A (es) |
| NZ (1) | NZ581702A (es) |
| PL (1) | PL2170942T3 (es) |
| PT (1) | PT2170942E (es) |
| RS (1) | RS52976B (es) |
| SI (1) | SI2170942T1 (es) |
| UA (1) | UA103598C2 (es) |
| WO (1) | WO2009000913A1 (es) |
| ZA (1) | ZA200908168B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202009009905U1 (de) | 2008-02-08 | 2009-10-29 | Biogenerix Ag | Flüssig-Formulierung von FSH |
| MX2011010480A (es) | 2009-04-01 | 2012-09-07 | Biogenerix Ag | Metodo para purificar una fsh recombinante. |
| EP2325194A1 (en) | 2009-11-24 | 2011-05-25 | Glycotope GmbH | Process for the purification of glycoproteins |
| JP6279466B2 (ja) * | 2012-04-27 | 2018-02-14 | Ｊｃｒファーマ株式会社 | 新規な発現ベクター |
| CN103539861B (zh) * | 2013-11-01 | 2015-02-18 | 广州联康生物科技有限公司 | 长效重组人促卵泡激素融合蛋白 |
| CN103554269B (zh) * | 2013-11-01 | 2015-02-11 | 广州联康生物科技有限公司 | 重组猪促卵泡激素融合蛋白 |
| CN103539860B (zh) * | 2013-11-01 | 2014-12-03 | 广州优联康医药科技有限公司 | 一种长效重组人促卵泡激素融合蛋白 |
| CN105462909B (zh) * | 2015-12-31 | 2019-09-27 | 哈药集团技术中心 | 一种高效表达人促卵泡激素的cho细胞的培养方法 |
| CN107460206B (zh) * | 2017-09-11 | 2020-05-01 | 深圳市深研生物科技有限公司 | 人fsh的重组表达载体、重组细胞株及重组人fsh的制备方法 |
| CN111349154A (zh) * | 2018-12-21 | 2020-06-30 | 江苏众红生物工程创药研究院有限公司 | 一种重组人促卵泡激素及其制备方法和药物应用 |
| CN110812366B (zh) * | 2019-11-18 | 2023-11-17 | 珠海丽凡达生物技术有限公司 | 一种可用于激素补充的mRNA药物及其制备方法 |
| CN120519466A (zh) * | 2025-07-23 | 2025-08-22 | 苏州晟济药业有限公司 | 卵泡刺激素表达系统 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| CA2018676C (en) * | 1989-06-20 | 2003-05-06 | Christie A. Kelton | Novel heteropolymeric protein production methods |
| EP0842275A1 (en) | 1995-02-17 | 1998-05-20 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | PRODUCTION OF BIOLOGICALLY ACTIVE RECOMBINANT BOVINE FOLLICLE STIMULATING HORMONE (REC bFSH) IN THE BACULOVIRUS EXPRESSION SYSTEM |
| TW518235B (en) | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
| JP4719357B2 (ja) | 1998-07-23 | 2011-07-06 | アレス トレイディング ソシエテ アノニム | Ｆｓｈ及びｆｓｈ変異体の製剤、製品及び方法 |
| PT1169349E (pt) | 1999-04-16 | 2007-06-18 | Inst Massone S A | Composições de gonadotropina de altamente purificada e processo para a sua preparação |
| US20020127652A1 (en) | 2000-02-11 | 2002-09-12 | Schambye Hans Thalsgard | Follicle stimulating hormones |
| WO2001058493A1 (en) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | Conjugates of follicle stimulating hormones |
| KR20050083691A (ko) * | 2002-09-13 | 2005-08-26 | 더 유니버시티 오브 퀸스랜드 | 코돈 번역 효율에 기초한 유전자 발현 시스템 |
| KR100533794B1 (ko) * | 2003-10-02 | 2005-12-07 | 주식회사 프로젠 | 인간 난포자극 호르몬을 대량으로 생산하는 방법 |
| AU2004309040B2 (en) | 2003-12-22 | 2010-12-16 | Ares Trading S.A. | Method for purifying FSH |
| ATE408624T1 (de) | 2004-11-09 | 2008-10-15 | Ares Trading Sa | Verfahren zur reinigung von fsh |
| TWI369401B (en) * | 2005-07-05 | 2012-08-01 | Ares Trading Sa | Serum-free culture medium for the production of recombinant gonadotropins |
| US20070281883A1 (en) | 2006-06-05 | 2007-12-06 | Hanna Rosenfeld | Development of follicle stimulating hormone agonists and antagonists in fish |
-
2008
- 2008-06-27 US US12/666,257 patent/US8318457B2/en not_active Expired - Fee Related
- 2008-06-27 WO PCT/EP2008/058274 patent/WO2009000913A1/en not_active Ceased
- 2008-06-27 EP EP12169533A patent/EP2492280A1/en not_active Withdrawn
- 2008-06-27 SI SI200831065T patent/SI2170942T1/sl unknown
- 2008-06-27 EP EP08774439.7A patent/EP2170942B1/en active Active
- 2008-06-27 ES ES08774439T patent/ES2432183T3/es active Active
- 2008-06-27 MX MX2010000385A patent/MX2010000385A/es active IP Right Grant
- 2008-06-27 PL PL08774439T patent/PL2170942T3/pl unknown
- 2008-06-27 AU AU2008267138A patent/AU2008267138B9/en active Active
- 2008-06-27 DK DK08774439.7T patent/DK2170942T3/da active
- 2008-06-27 EA EA201070071A patent/EA022993B1/ru not_active IP Right Cessation
- 2008-06-27 RS RS20130443A patent/RS52976B/sr unknown
- 2008-06-27 CA CA2690844A patent/CA2690844C/en not_active Expired - Fee Related
- 2008-06-27 NZ NZ581702A patent/NZ581702A/en not_active IP Right Cessation
- 2008-06-27 CN CN200880022358.7A patent/CN101720332B/zh not_active Expired - Fee Related
- 2008-06-27 BR BRPI0813913-0A patent/BRPI0813913B1/pt not_active IP Right Cessation
- 2008-06-27 JP JP2010513938A patent/JP5570980B2/ja not_active Expired - Fee Related
- 2008-06-27 HR HRP20130921AT patent/HRP20130921T1/hr unknown
- 2008-06-27 PT PT87744397T patent/PT2170942E/pt unknown
- 2008-06-27 KR KR1020107001959A patent/KR101522217B1/ko not_active Expired - Fee Related
- 2008-06-27 UA UAA201000813A patent/UA103598C2/uk unknown
-
2009
- 2009-11-20 ZA ZA200908168A patent/ZA200908168B/xx unknown
- 2009-11-23 IL IL202280A patent/IL202280A/en active IP Right Grant
-
2013
- 2013-10-09 CY CY20131100874T patent/CY1114463T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |