[go: up one dir, main page]

MX2009013677A - Derivados de 4,5-dihidro-(1h)-pirazol como moduladores de receptores cb1 cannabinoides. - Google Patents

Derivados de 4,5-dihidro-(1h)-pirazol como moduladores de receptores cb1 cannabinoides.

Info

Publication number
MX2009013677A
MX2009013677A MX2009013677A MX2009013677A MX2009013677A MX 2009013677 A MX2009013677 A MX 2009013677A MX 2009013677 A MX2009013677 A MX 2009013677A MX 2009013677 A MX2009013677 A MX 2009013677A MX 2009013677 A MX2009013677 A MX 2009013677A
Authority
MX
Mexico
Prior art keywords
cannabinoid
dihydro
receptor modulators
compounds
methods
Prior art date
Application number
MX2009013677A
Other languages
English (en)
Inventor
Josephus H M Lange
Bernard J Van Vliet
Mahmut Yildirim
Hendrik C Wals
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Priority claimed from PCT/EP2008/057367 external-priority patent/WO2008152086A2/en
Publication of MX2009013677A publication Critical patent/MX2009013677A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invenci?n se refiere a derivados de 4,5-dihidro-(1H)-pirazol (pirazolina) como moduladores de los receptores CB1 cannabinoides, a composiciones farmac?uticas que contienen estos compuestos, a m?todos para su s?ntesis, a m?todos para preparar novedosos intermediarios ?tiles para sus s?ntesis, y a m?todos para preparar composiciones: la invenci?n tambi?n se refiere a los usos de tales compuestos y composiciones, particularmente su uso en la administraci?n de los mismos a pacientes para lograr un efecto terap?utico en trastornos en los cuales est?n involucrados los receptores CB1 o que pueden ser tratados mediante manipulaci?n de esos receptores; los compuestos tienen la f?rmula (I) (ver f?rmula (I)) en donde los s?mbolos tienen los significados dados en la especificaci?n.
MX2009013677A 2007-06-15 2008-06-12 Derivados de 4,5-dihidro-(1h)-pirazol como moduladores de receptores cb1 cannabinoides. MX2009013677A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07110327 2007-06-15
PCT/EP2008/057367 WO2008152086A2 (en) 2007-06-15 2008-06-12 4,5-dihydro-(1h)-pyrazole derivatives as cannabinoid cb1 receptor modulators

Publications (1)

Publication Number Publication Date
MX2009013677A true MX2009013677A (es) 2010-04-07

Family

ID=38674907

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013677A MX2009013677A (es) 2007-06-15 2008-06-12 Derivados de 4,5-dihidro-(1h)-pirazol como moduladores de receptores cb1 cannabinoides.

Country Status (5)

Country Link
CN (1) CN101939300A (es)
AR (1) AR066961A1 (es)
BR (1) BRPI0813367A2 (es)
MX (1) MX2009013677A (es)
TW (1) TW200916442A (es)

Also Published As

Publication number Publication date
BRPI0813367A2 (pt) 2016-10-25
TW200916442A (en) 2009-04-16
CN101939300A (zh) 2011-01-05
AR066961A1 (es) 2009-09-23

Similar Documents

Publication Publication Date Title
GEP20135907B (en) L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators
NO20083193L (no) 4,5-dihydro-(1H)-pyrazolderivater som cannabinoid CB1-reseptormodulatorer
TN2011000209A1 (en) Aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators
MX2008012400A (es) Azolopirimidinas como inhibidores de actividad de cannabinoide 1.
WO2009010455A3 (en) Pyrazole derivatives as modulators of metabotropic glutamate receptors
EA018629B8 (ru) Производные фенил- и бензодиоксинилзамещенных индазолов
MX2009006540A (es) Derivados de ester y amida de indazolilo para el tratamiento de enfermedades mediadas por un receptor de glucocorticoides.
WO2009106980A3 (en) Indazole derivatives
MY147677A (en) Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases
MX2012002583A (es) Moduladores de piranil aril metil benzoquinazolinona alostericos positivos del receptor m1.
MX2011006132A (es) Imidazol carboxamidas fusionadas como moduladores de trpv3.
MX2010009462A (es) Derivados de indazol.
PH12012501863A1 (en) 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
MX2009003981A (es) Agentes moduladores del receptor de calcio.
WO2006067428A3 (en) 1, 2-diphenyl-imidazole derivatives and their use as cb1 receptor ligands
NO20090539L (no) Azaindolderivater med en kombinasjon av partiell nikotinacetylcholinreseptoragonisme og dopamin gjenopptakelsesinhibisjon
WO2009037244A3 (en) 5-aryl-4,5-dihydro-(1h)-pyrazoles as cannabinoid cb1 receptor agonists
GB0611907D0 (en) Compounds
ATE407119T1 (de) Pyridinderivate und deren verwendung als modulatoren des cb2-rezeptors
MX2010003059A (es) 5-aril-4,5-dihidro-(1h)-pirazoles como agonistas de receptores cb1 cannabinoides.
IN2014KN00849A (es)
TW200730500A (en) 4, 5-dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators
WO2008152086A3 (en) 4,5-dihydro-(1h)-pyrazole derivatives as cannabinoid cb1 receptor modulators
MX2014003455A (es) Derivados de metanosulfonamida sustituidos con arilo o n-heteroarilo como ligandos de receptor vanilloide.
GB0519760D0 (en) Novel compounds