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MX2009012787A - Nuevas fenilpirrolidinas disustituidas como moduladores de neurotransmision catecolaminergica cortical. - Google Patents

Nuevas fenilpirrolidinas disustituidas como moduladores de neurotransmision catecolaminergica cortical.

Info

Publication number
MX2009012787A
MX2009012787A MX2009012787A MX2009012787A MX2009012787A MX 2009012787 A MX2009012787 A MX 2009012787A MX 2009012787 A MX2009012787 A MX 2009012787A MX 2009012787 A MX2009012787 A MX 2009012787A MX 2009012787 A MX2009012787 A MX 2009012787A
Authority
MX
Mexico
Prior art keywords
modulators
disubstituted
phenylpyrrolidines
cortical
catecholaminergic neurotransmission
Prior art date
Application number
MX2009012787A
Other languages
English (en)
Inventor
Lars Swanson
Nicholas Waters
Clas Sonesson
Fredrik Pettersson
Susanna Waters
Original Assignee
Nsab Af Neurosearch Sweden Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nsab Af Neurosearch Sweden Ab filed Critical Nsab Af Neurosearch Sweden Ab
Publication of MX2009012787A publication Critical patent/MX2009012787A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere al uso de compuestos que incrementan los niveles extracelulares de las catecolaminas, dopamina y norepinefrina, en áreas cortical y cerebral del cerebro mamífero, y de manera más especifica al uso de fenil-1-pirrolidinoles 3-disubstituidos para el tratamiento de trastornos del sistema nervioso central.
MX2009012787A 2007-06-05 2008-06-04 Nuevas fenilpirrolidinas disustituidas como moduladores de neurotransmision catecolaminergica cortical. MX2009012787A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94199407P 2007-06-05 2007-06-05
SE0701387 2007-06-05
PCT/EP2008/056915 WO2008148801A2 (en) 2007-06-05 2008-06-04 Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Publications (1)

Publication Number Publication Date
MX2009012787A true MX2009012787A (es) 2009-12-15

Family

ID=39743744

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012787A MX2009012787A (es) 2007-06-05 2008-06-04 Nuevas fenilpirrolidinas disustituidas como moduladores de neurotransmision catecolaminergica cortical.

Country Status (16)

Country Link
US (1) US8188301B2 (es)
EP (1) EP2155671B8 (es)
JP (1) JP5444535B2 (es)
KR (1) KR20100038295A (es)
CN (1) CN101808987A (es)
AU (1) AU2008258599B2 (es)
BR (1) BRPI0812740A2 (es)
CA (1) CA2690091A1 (es)
CO (1) CO6251288A2 (es)
IL (1) IL202045A0 (es)
MX (1) MX2009012787A (es)
NZ (1) NZ581364A (es)
RU (1) RU2471781C2 (es)
UA (1) UA98783C2 (es)
WO (1) WO2008148801A2 (es)
ZA (1) ZA200908592B (es)

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EP2155671B8 (en) 2007-06-05 2018-02-21 Integrative Research Laboratories Sweden AB Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
NZ592566A (en) 2008-11-24 2013-03-28 Nsab Af Neurosearch Sweden Ab 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
EP2367785B1 (en) 2008-11-24 2014-10-15 Integrative Research Laboratories Sweden AB Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
US20110257148A1 (en) * 2008-11-24 2011-10-20 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Novel 1-alkyl-3-hydroxy-3-phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
KR101881596B1 (ko) 2008-12-02 2018-07-24 웨이브 라이프 사이언시스 재팬 인코포레이티드 인 원자 변형된 핵산의 합성 방법
WO2010071575A1 (en) * 2008-12-16 2010-06-24 Astrazeneca Ab Quaternary piperidine derivatives and uses thereof
RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
JP5868324B2 (ja) * 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
BR112014001244A2 (pt) 2011-07-19 2017-02-21 Wave Life Sciences Pte Ltd métodos para a síntese de ácidos nucléicos funcionalizados
ES2862073T3 (es) 2012-07-13 2021-10-06 Wave Life Sciences Ltd Grupo auxiliar asimétrico
BR112015000723A2 (pt) 2012-07-13 2017-06-27 Shin Nippon Biomedical Laboratories Ltd adjuvante de ácido nucléico quiral
CN112007045A (zh) 2012-07-13 2020-12-01 波涛生命科学有限公司 手性控制
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
EP3095460A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
NZ737451A (en) 2015-05-20 2022-01-28 Integrative Res Laboratories Sweden Ab Novel azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
ES2805031T3 (es) 2016-02-10 2021-02-10 Sumitomo Chemical Co Método de producción de 1-metilpirrolidin-3-ol
ES2943252T3 (es) 2017-05-19 2023-06-12 Integrative Res Laboratories Sweden Ab Fumarato de (+)-3-(2,3-difluorofenil)-3-metoxipirrolidina, un proceso para su preparación y sus usos

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Also Published As

Publication number Publication date
RU2471781C2 (ru) 2013-01-10
CN101808987A (zh) 2010-08-18
RU2009143104A (ru) 2011-07-20
US20100179211A1 (en) 2010-07-15
UA98783C2 (en) 2012-06-25
ZA200908592B (en) 2011-02-23
WO2008148801A8 (en) 2009-12-10
EP2155671B1 (en) 2017-12-20
BRPI0812740A2 (pt) 2016-07-19
JP5444535B2 (ja) 2014-03-19
NZ581364A (en) 2011-10-28
AU2008258599A1 (en) 2008-12-11
CA2690091A1 (en) 2008-12-11
IL202045A0 (en) 2010-06-16
EP2155671B8 (en) 2018-02-21
WO2008148801A2 (en) 2008-12-11
AU2008258599B2 (en) 2013-06-13
CO6251288A2 (es) 2011-02-21
JP2010529081A (ja) 2010-08-26
WO2008148801A3 (en) 2009-01-29
KR20100038295A (ko) 2010-04-14
US8188301B2 (en) 2012-05-29
EP2155671A2 (en) 2010-02-24

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