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MX2009011926A - Metodo para la sintesis del acido (z)-3-[2-butoxi-3´-(3-heptil-1-m etil-ureido)-bifenil-4-il]-2-metoxi-acrilico. - Google Patents

Metodo para la sintesis del acido (z)-3-[2-butoxi-3´-(3-heptil-1-m etil-ureido)-bifenil-4-il]-2-metoxi-acrilico.

Info

Publication number
MX2009011926A
MX2009011926A MX2009011926A MX2009011926A MX2009011926A MX 2009011926 A MX2009011926 A MX 2009011926A MX 2009011926 A MX2009011926 A MX 2009011926A MX 2009011926 A MX2009011926 A MX 2009011926A MX 2009011926 A MX2009011926 A MX 2009011926A
Authority
MX
Mexico
Prior art keywords
synthesis
methyl
ureido
heptyl
butoxy
Prior art date
Application number
MX2009011926A
Other languages
English (en)
Inventor
Jean-Guy Boiteau
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of MX2009011926A publication Critical patent/MX2009011926A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/57—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
    • C07C309/58—Carboxylic acid groups or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención se refiere a un método para la síntesis del ácido (Z)-3-[2-butoxi-3´-(3-heptil-1-metil-ureido)-bifenil-4-il]-2-meto xi-acrílico de la fórmula (I), e igualmente al método para la síntesis de los compuestos intermedios de la reacción de la fórmula general (XII) así como a los compuestos cuando R2 es elegido entre los radicales metilo, trifluorometilo, fenilo y 4-tolilo, fórmula (XII).
MX2009011926A 2007-05-11 2008-04-18 Metodo para la sintesis del acido (z)-3-[2-butoxi-3´-(3-heptil-1-m etil-ureido)-bifenil-4-il]-2-metoxi-acrilico. MX2009011926A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0755021A FR2915994B1 (fr) 2007-05-11 2007-05-11 Procede de synthese de l'acide (z)-3-[2-butoxy-3'-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl] -2-methoxy-acrylique.
PCT/FR2008/050706 WO2008139121A2 (fr) 2007-05-11 2008-04-18 Procede de synthese de l'acide (z)-3-[2-butoxy-3'-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylique

Publications (1)

Publication Number Publication Date
MX2009011926A true MX2009011926A (es) 2009-11-18

Family

ID=38776289

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011926A MX2009011926A (es) 2007-05-11 2008-04-18 Metodo para la sintesis del acido (z)-3-[2-butoxi-3´-(3-heptil-1-m etil-ureido)-bifenil-4-il]-2-metoxi-acrilico.

Country Status (13)

Country Link
US (1) US8357819B2 (es)
EP (1) EP2146954B1 (es)
JP (1) JP5373771B2 (es)
KR (1) KR20100016412A (es)
CN (1) CN101679225B (es)
AU (1) AU2008249831A1 (es)
BR (1) BRPI0810281A2 (es)
CA (1) CA2686388A1 (es)
ES (1) ES2397489T3 (es)
FR (1) FR2915994B1 (es)
MX (1) MX2009011926A (es)
RU (1) RU2478614C2 (es)
WO (1) WO2008139121A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590615A (zh) * 2019-10-03 2019-12-20 南京施倍泰生物科技有限公司 一类新型阿魏酸磺酸酯衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794742B1 (fr) * 1999-06-11 2005-06-03 Sanofi Synthelabo Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant
EP1687250A1 (en) * 2003-11-27 2006-08-09 Takasago International Corporation Process for producing optically active 3-(4-hydroxyphenyl)propionic acids
FR2892412B1 (fr) * 2005-10-26 2008-05-16 Galderma Res & Dev Composes biaromatiques modulateurs des ppars

Also Published As

Publication number Publication date
CA2686388A1 (fr) 2008-11-20
RU2009145947A (ru) 2011-06-20
WO2008139121A2 (fr) 2008-11-20
AU2008249831A1 (en) 2008-11-20
JP2010526798A (ja) 2010-08-05
FR2915994A1 (fr) 2008-11-14
CN101679225A (zh) 2010-03-24
KR20100016412A (ko) 2010-02-12
WO2008139121A3 (fr) 2009-02-19
BRPI0810281A2 (pt) 2014-12-30
RU2478614C2 (ru) 2013-04-10
JP5373771B2 (ja) 2013-12-18
US8357819B2 (en) 2013-01-22
CN101679225B (zh) 2014-04-02
EP2146954A2 (fr) 2010-01-27
EP2146954B1 (fr) 2012-10-31
US20100286430A1 (en) 2010-11-11
FR2915994B1 (fr) 2009-07-03
ES2397489T3 (es) 2013-03-07

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