MX2009009575A - Metodos e intemediarios para la sintesis de inhibidores selectivos de dpp-iv. - Google Patents
Metodos e intemediarios para la sintesis de inhibidores selectivos de dpp-iv.Info
- Publication number
- MX2009009575A MX2009009575A MX2009009575A MX2009009575A MX2009009575A MX 2009009575 A MX2009009575 A MX 2009009575A MX 2009009575 A MX2009009575 A MX 2009009575A MX 2009009575 A MX2009009575 A MX 2009009575A MX 2009009575 A MX2009009575 A MX 2009009575A
- Authority
- MX
- Mexico
- Prior art keywords
- intermediates
- synthesis
- methods
- inhibitors
- dpp
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 3
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 3
- -1 carboxylate salt Chemical class 0.000 abstract 2
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical class C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan métodos e intermediarios para la síntesis de inhibidores selectivos de dipeptidil peptidasa IV (DPP-IV). El acoplamiento de una sal de carboxilato con un derivado de boroprolina proporciona una forma protegida de un inhibidor de DPP-IV, que puede ser desbloqueada para producir el compuesto medicinal. La sal de carboxilato puede ser una forma cristalina de una sal de sodio o una sal de diciclohexilamonio. El inhibidor puede ser utilizado en el tratamiento de diabetes.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89384207P | 2007-03-08 | 2007-03-08 | |
| US95922607P | 2007-07-12 | 2007-07-12 | |
| US2348708P | 2008-01-25 | 2008-01-25 | |
| US2950608P | 2008-02-18 | 2008-02-18 | |
| PCT/US2008/055927 WO2008109681A2 (en) | 2007-03-08 | 2008-03-05 | Methods and intermediates for synthesis of selective dpp-iv inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009009575A true MX2009009575A (es) | 2009-11-12 |
Family
ID=39711954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009009575A MX2009009575A (es) | 2007-03-08 | 2008-03-05 | Metodos e intemediarios para la sintesis de inhibidores selectivos de dpp-iv. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP2173709A2 (es) |
| CN (1) | CN101679238A (es) |
| AR (1) | AR065666A1 (es) |
| CA (1) | CA2680133A1 (es) |
| MX (1) | MX2009009575A (es) |
| TW (1) | TW200843784A (es) |
| WO (1) | WO2008109681A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080036125A (ko) | 2005-08-01 | 2008-04-24 | 페노믹스 코포레이션 | 헤테로시클릭 보론산 및 그의 유도체의 제조 방법 |
| CL2007002499A1 (es) | 2006-08-30 | 2008-03-14 | Phenomix Corp | Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes. |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| NZ604091A (en) | 2008-08-15 | 2014-08-29 | Boehringer Ingelheim Int | Purin derivatives for use in the treatment of fab-related diseases |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| AR075204A1 (es) | 2009-01-29 | 2011-03-16 | Boehringer Ingelheim Int | Inhibidores de dpp-4 y composiciones farmaceuticas que los comprenden, utiles para tratar enfermedades metabolicas en pacientes pediatricos, particularmente diabetes mellitus tipo 2 |
| MX2011008416A (es) | 2009-02-13 | 2011-09-08 | Boehringer Ingelheim Int | Medicaciones antidiabeticas que comprenden un inhibidor de dpp-4 (linagliptina) opcionalmente en combinacion con otros antidiabeticos. |
| PH12012501037A1 (en) | 2009-11-27 | 2013-01-14 | Boehringer Ingelheim Int | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
| JP2013522279A (ja) | 2010-03-18 | 2013-06-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病及び関連状態の治療で用いるｇｐｒ１１９作動薬とｄｄｐ−ｉｖ阻害薬リナグリプチンの組合せ |
| CA2797310C (en) | 2010-05-05 | 2020-03-31 | Boehringer Ingelheim International Gmbh | Glp-1 receptor agonist and dpp-4 inhibitor combination therapy |
| KR20230051307A (ko) | 2010-06-24 | 2023-04-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| CN111533675B (zh) * | 2019-11-29 | 2021-09-28 | 杭州华东医药集团新药研究院有限公司 | 杂环硼酸化合物的杂质及其控制方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7317109B2 (en) * | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| KR20080036125A (ko) * | 2005-08-01 | 2008-04-24 | 페노믹스 코포레이션 | 헤테로시클릭 보론산 및 그의 유도체의 제조 방법 |
-
2008
- 2008-03-05 WO PCT/US2008/055927 patent/WO2008109681A2/en not_active Ceased
- 2008-03-05 MX MX2009009575A patent/MX2009009575A/es not_active Application Discontinuation
- 2008-03-05 CA CA002680133A patent/CA2680133A1/en not_active Abandoned
- 2008-03-05 EP EP08743692A patent/EP2173709A2/en not_active Withdrawn
- 2008-03-05 CN CN200880015066A patent/CN101679238A/zh active Pending
- 2008-03-07 AR ARP080100973A patent/AR065666A1/es not_active Application Discontinuation
- 2008-03-07 TW TW097108175A patent/TW200843784A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008109681A2 (en) | 2008-09-12 |
| WO2008109681A3 (en) | 2008-11-13 |
| CN101679238A (zh) | 2010-03-24 |
| TW200843784A (en) | 2008-11-16 |
| EP2173709A2 (en) | 2010-04-14 |
| CA2680133A1 (en) | 2008-09-12 |
| AR065666A1 (es) | 2009-06-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2009009575A (es) | Metodos e intemediarios para la sintesis de inhibidores selectivos de dpp-iv. | |
| GEP20094679B (en) | Dipeptidyl peptidase inhibitors | |
| PL2247602T3 (pl) | Pochodne O-glukuronido-adamantylowe jako inhibitory dipeptydylopeptydazy IV do leczenia cukrzycy | |
| IL174608A0 (en) | Pyridine compounds as inhibitors of dipeptidyl peptidase iv | |
| HUS1400009I1 (hu) | Dipeptidil peptidáz inhibitorok adagolása | |
| WO2008040995A8 (en) | Indazoles for use as dpp-iv inhibitors | |
| GB2465132B (en) | Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors | |
| AP2006003770A0 (en) | Proline derivatives and their use as dipeptidyl peptidase IV inhibitors | |
| GEP20125537B (en) | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | |
| MX2009009786A (es) | Inhibidores de la via de hedgehog. | |
| EP1997533B8 (en) | Heterocyclic boronic acid compounds, dipeptidyl peptidase IV inhibitors | |
| TW200614988A (en) | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation | |
| EP2133077A4 (en) | DERIVATIVES OF AZABICYCLOOCTAN; PROCESS FOR THEIR PREPARATION AND THEIR USES AS AN INHIBITORS OF DIPEPTIDYLPEPTIDASE IV | |
| PT1928499E (pt) | Utilização de um inibidor da dpp-iv para reduzir eventos hipoglicémicos | |
| PT2358717E (pt) | Aminotetra-hidropiranos como inibidores da enzima dipeptidil peptidase-iv no tratamento ou prevenção da diabetes | |
| MY155630A (en) | Pyrrolidine derivatives | |
| TW200740776A (en) | N-phenylbenzotriazolyl c-kit inhibitors | |
| TN2012000152A1 (en) | Spiropiperidine compounds and pharmaceutical use thereof for treating diabetes | |
| IL189544A0 (en) | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv) | |
| IL173802A0 (en) | Adamantane and azabicyclo-octane and nonane derivatives, process of their preparation and their use as dpp-iv inhibitors | |
| EP2130825A4 (en) | N-SUBSTITUTED THIOMORPHOLIN DERIVATIVES AS INHIBITORS OF DIPEPTIDYLPEPTIDASE IV AND THEIR PHARMACEUTICAL USE | |
| CO6700826A2 (es) | Método para la producción de un compuesto que contiene nitrógeno en un heterociclo y que es intermediarioen la producción de un compuesto inhibidor de dpp-iv | |
| MX2010006218A (es) | Compuestos organicos. | |
| WO2006134613A3 (en) | Novel 5-substituted indole derivatives as dipeptidyl peptidase iv (dpp-iv) inhibitors | |
| WO2007120669A8 (en) | Tetrahalogenated compounds useful as inhibitors of angiogenesis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |