MX2009008998A - Moduladores del receptor activado por proliferador de peroxisoma. - Google Patents
Moduladores del receptor activado por proliferador de peroxisoma.Info
- Publication number
- MX2009008998A MX2009008998A MX2009008998A MX2009008998A MX2009008998A MX 2009008998 A MX2009008998 A MX 2009008998A MX 2009008998 A MX2009008998 A MX 2009008998A MX 2009008998 A MX2009008998 A MX 2009008998A MX 2009008998 A MX2009008998 A MX 2009008998A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- receptor modulators
- activated receptor
- peroxisome proliferator
- proliferator activated
- Prior art date
Links
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 235000019000 fluorine Nutrition 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a compuestos de la Fórmula estructural: en donde: R1 es -H o -alquilo C1-C3; R2 se selecciona a partir del grupo que consiste de -H, -alquilo C1-C4, -alquilo C1-C3-CF3, fenilo, y piridinilo; y R3 se selecciona a partir del grupo que consiste de -H, -alquilo C1-C4, -alquilo C1-C3-O-CH3, -CH2-ciclopropilo, -CH2-C=CH2, - CH2CH2-(2-F-fenilo), y fenilo sustituido con desde 1 a 2 fluoros; siempre que cuando R1 y R2 sean cada uno H, entonces R3 se selecciona a partir del grupo que consiste de -alquilo C1-C4, -alquilo C1-C3-O-CH3, -CH2-ciclopropilo, -CH2-C=CH2, -CH2CH2-(2-F-fenilo), y fenilo sustituido con desde 1 a 2 fluoros; o estereoisómeros y sales de los mismos farmacéuticamente aceptables. (ver fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89126107P | 2007-02-23 | 2007-02-23 | |
| PCT/US2008/053653 WO2008103574A2 (en) | 2007-02-23 | 2008-02-12 | Peroxisome proliferator activated receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009008998A true MX2009008998A (es) | 2009-09-02 |
Family
ID=39691178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009008998A MX2009008998A (es) | 2007-02-23 | 2008-02-12 | Moduladores del receptor activado por proliferador de peroxisoma. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100099725A1 (es) |
| EP (1) | EP2129667A2 (es) |
| JP (1) | JP2010519308A (es) |
| KR (1) | KR20090129406A (es) |
| CN (1) | CN101616900A (es) |
| AU (1) | AU2008218841A1 (es) |
| BR (1) | BRPI0807949A2 (es) |
| CA (1) | CA2678846A1 (es) |
| EA (1) | EA200970793A1 (es) |
| MX (1) | MX2009008998A (es) |
| WO (1) | WO2008103574A2 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101643451B (zh) * | 2008-08-07 | 2013-03-06 | 浙江海正药业股份有限公司 | 过氧化物酶增殖物激活受体亚型δ类激动剂化合物及其制备方法 |
| CA2740366A1 (en) * | 2008-10-21 | 2010-04-29 | Metabolex, Inc. | Aryl gpr120 receptor agonists and uses thereof |
| WO2010071813A1 (en) * | 2008-12-19 | 2010-06-24 | Aryx Therapeutics, Inc. | AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α |
| WO2012029340A1 (ja) * | 2010-08-31 | 2012-03-08 | コニカミノルタエムジー株式会社 | Ｘ線撮影システム |
| EP2822931B1 (en) | 2012-03-09 | 2017-05-03 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| JP6404230B2 (ja) | 2012-12-20 | 2018-10-10 | インセプション ２、 インコーポレイテッド | トリアゾロン化合物およびその使用 |
| WO2014202510A1 (de) | 2013-06-20 | 2014-12-24 | Bayer Cropscience Ag | Arylsulfid- und arylsulfoxid-derivate als akarizide und insektizide |
| ES2712211T3 (es) | 2013-06-20 | 2019-05-09 | Bayer Cropscience Ag | Derivados de arilsulfuro y arilsulfóxido acaricidas e insecticidas |
| AR096816A1 (es) | 2013-07-08 | 2016-02-03 | Bayer Cropscience Ag | Derivados de arilsulfuro y arilsulfóxido de seis miembros enlazados con c-n como agentes para combatir parásitos |
| CA2921420A1 (en) | 2013-09-06 | 2015-03-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| CN114853686B (zh) * | 2021-08-23 | 2023-06-20 | 中国药科大学 | 三氮唑酮类化合物及其医药用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA82048C2 (uk) * | 2000-11-10 | 2008-03-11 | Эли Лилли Энд Компани | Агоністи альфа-рецепторів, активованих проліфератором пероксисом |
| GB0111523D0 (en) * | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
| US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| AU2003296401A1 (en) * | 2003-01-06 | 2004-08-10 | Eli Lilly And Company | A pyrazole derivative as ppar modulator |
-
2008
- 2008-02-12 US US12/522,723 patent/US20100099725A1/en not_active Abandoned
- 2008-02-12 BR BRPI0807949-8A patent/BRPI0807949A2/pt not_active IP Right Cessation
- 2008-02-12 CN CN200880005443A patent/CN101616900A/zh active Pending
- 2008-02-12 JP JP2009550963A patent/JP2010519308A/ja not_active Withdrawn
- 2008-02-12 MX MX2009008998A patent/MX2009008998A/es not_active Application Discontinuation
- 2008-02-12 EP EP08743458A patent/EP2129667A2/en not_active Withdrawn
- 2008-02-12 AU AU2008218841A patent/AU2008218841A1/en not_active Abandoned
- 2008-02-12 CA CA002678846A patent/CA2678846A1/en not_active Abandoned
- 2008-02-12 WO PCT/US2008/053653 patent/WO2008103574A2/en not_active Ceased
- 2008-02-12 KR KR1020097017356A patent/KR20090129406A/ko not_active Withdrawn
- 2008-02-12 EA EA200970793A patent/EA200970793A1/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010519308A (ja) | 2010-06-03 |
| KR20090129406A (ko) | 2009-12-16 |
| US20100099725A1 (en) | 2010-04-22 |
| AU2008218841A1 (en) | 2008-08-28 |
| WO2008103574A3 (en) | 2008-12-18 |
| CN101616900A (zh) | 2009-12-30 |
| CA2678846A1 (en) | 2008-08-28 |
| BRPI0807949A2 (pt) | 2014-06-03 |
| EP2129667A2 (en) | 2009-12-09 |
| EA200970793A1 (ru) | 2010-02-26 |
| WO2008103574A2 (en) | 2008-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2009008998A (es) | Moduladores del receptor activado por proliferador de peroxisoma. | |
| MX2008016423A (es) | Arilamidas sustituidas con tetrazol. | |
| NO20063866L (no) | 1,3,5-trisubstituerte 4,5-di hydro-1 H-pyrazolderivater med CB1-antagonistisk aktivitet. | |
| NZ612000A (en) | Bicyclo[3.2.1]octyl amide derivatives and uses of same | |
| NZ596826A (en) | Polycyclic antagonists of lysophosphatidic acid receptors | |
| MY160424A (en) | Substituted pyrrolidine-2-carboxyamides. | |
| MX2009005217A (es) | Compuestos heterociclicos que contienen nitrogeno y metodos de uso de los mismos. | |
| MXPA04006322A (es) | Derivados de 6-fluorobiciclo[3.1.0]hexano. | |
| UA102310C2 (ru) | Гетероциклические сульфонамиды, их применение и фармацевтические композиции | |
| MX2009004822A (es) | Compuestos de fenilpropionamida y usos de los mismos. | |
| PT2139334E (pt) | Compostos heterocíclicos fusionados de 2-cianofenilo, e composições e utilizações dos mesmos | |
| PE20140868A1 (es) | Antagonistas trpm8 y su uso en tratamientos | |
| HRP20130614T1 (en) | Novel pyrazole-substituted arylamides | |
| MX2007014405A (es) | Novedosos derivados de oxadiazol y su uso como moduladores aloestericos positivos de los receptores de glutamato metabotropicos. | |
| PH12013501572A1 (en) | 5-(phenyl/pyridinyl-ethinyl)-2-pyridine/ 2-pyrimidine-carborxamides as mglur5 modulators | |
| PH12014500775A1 (en) | Ethynyl derivatives as mglur5 allosteric modulators | |
| MX2010004272A (es) | Derivados de tetrazol como moduladores de receptores de glutamato metabotropicos (mglurs). | |
| MY149400A (en) | Bridged six-membered ring compounds | |
| MX2010001566A (es) | Derivado de aminopirazolamida. | |
| MX2007014444A (es) | Derivados de oxadiazol sustituido como moduladores aloestericos positivos de los receptores de glutamato metabotropicos. | |
| CL2009001146A1 (es) | Compuestos derivados de 5-(5-(2-(3,5-bis(trifluorometil)fenil)-n,2-dimetilpropanoamida)-4-(4-fluoro-2-metilfenil)piridin-2-il)pirrolidin-2-carboxamida, antagonistas de los receptores nk-1; composicion farmaceutica; y uso del compuesto para el tratamiento de la depresion; ansiedad, trastornos del sueño o emesis. | |
| EP2238105A4 (en) | NOVEL COMPOUNDS, ISOMERS, OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF, CONTAINING VANILLOID RECEPTOR ANTAGONISTS, AND PHARMACEUTICAL COMPOSITIONS THEREWITH | |
| ATE512142T1 (de) | Pyrimidin- und chinazolinderivate als modulatoren der somatostatin-rezeptor aktivität | |
| NZ600266A (en) | Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use | |
| WO2009145591A3 (en) | Phenyl piperazine compounds, pharmaceutical composition including the same, and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HH | Correction or change in general | ||
| FA | Abandonment or withdrawal |