[go: up one dir, main page]

MX2009008158A - Sintesis enantioselectiva de 6-amino-7-hidroxi-4,5,6,7-tetrahidro- imidazo[4,5,1-jk][1]-benzazepin-2[1h]-ona y zilpaterol. - Google Patents

Sintesis enantioselectiva de 6-amino-7-hidroxi-4,5,6,7-tetrahidro- imidazo[4,5,1-jk][1]-benzazepin-2[1h]-ona y zilpaterol.

Info

Publication number
MX2009008158A
MX2009008158A MX2009008158A MX2009008158A MX2009008158A MX 2009008158 A MX2009008158 A MX 2009008158A MX 2009008158 A MX2009008158 A MX 2009008158A MX 2009008158 A MX2009008158 A MX 2009008158A MX 2009008158 A MX2009008158 A MX 2009008158A
Authority
MX
Mexico
Prior art keywords
benzazepin
imidazo
tetrahydro
hydroxy
amino
Prior art date
Application number
MX2009008158A
Other languages
English (en)
Inventor
Thorsten Meyer
Juan Jose Almena-Perea
Monica Brink
Gerhard Geiss
Renat Kadyrov
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of MX2009008158A publication Critical patent/MX2009008158A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fodder In General (AREA)

Abstract

La invención se refiere a un proceso para la hidrogenación de una cetooxima para selectivamente formar un estereoisómero de aminoalcohol, y, en particular, a un proceso para la hidrogenación de 4,5-dihidro-imidazo[4,5,1-jkl[1]benzazepin-2,6,7[ 1H]-triona-6-oxima o una sal del mismo para selectivamente formar un estereoisómero de 6-amino-7-hidroxi-4,5,6,7-tetrahidro-imidazo[ 4,5,1-jk][1]-benzazepin-2[1H]-ona o una sal del mismo. Esta invención también se refiere al uso de un producto de hidrogenación de 6-amino-7-hidroxi-4,5,6,7-tetrahidro-imidazo[4,5, 1-jk][1]-benzazepin-2[1H]-ona o una sal del mismo para selectivamente hacer un estereoisómero de zilpaterol o una sal del mismo, así como el uso de un estereoisómero de zilpaterol o sal en métodos de tratamiento y medicamentos para animales.
MX2009008158A 2007-02-01 2008-01-31 Sintesis enantioselectiva de 6-amino-7-hidroxi-4,5,6,7-tetrahidro- imidazo[4,5,1-jk][1]-benzazepin-2[1h]-ona y zilpaterol. MX2009008158A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89933607P 2007-02-01 2007-02-01
PCT/EP2008/051206 WO2008092924A1 (en) 2007-02-01 2008-01-31 Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk] [1] -benzazepin-2 [1h] -one and zilpaterol

Publications (1)

Publication Number Publication Date
MX2009008158A true MX2009008158A (es) 2009-09-23

Family

ID=39430962

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008158A MX2009008158A (es) 2007-02-01 2008-01-31 Sintesis enantioselectiva de 6-amino-7-hidroxi-4,5,6,7-tetrahidro- imidazo[4,5,1-jk][1]-benzazepin-2[1h]-ona y zilpaterol.

Country Status (14)

Country Link
US (1) US8629134B2 (es)
EP (1) EP2109614B1 (es)
JP (1) JP5126626B2 (es)
KR (1) KR101150634B1 (es)
CN (1) CN101600719B (es)
AU (1) AU2008209743B2 (es)
BR (1) BRPI0807865A2 (es)
CA (1) CA2675651C (es)
IL (1) IL199772A (es)
MX (1) MX2009008158A (es)
RU (1) RU2433131C2 (es)
SI (1) SI2109614T1 (es)
WO (1) WO2008092924A1 (es)
ZA (1) ZA200905103B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008012343A2 (en) * 2006-07-28 2008-01-31 Intervet International B.V. Macrolide synthesis process
CA2675651C (en) 2007-02-01 2012-10-02 Intervet International B.V. Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk] [1] -benzazepin-2 [1h] -one and zilpaterol
MX2009010499A (es) * 2007-03-31 2009-10-19 Intervet Int Bv Procesos para elaborar zilpaterol y sales del mismo.
TW201033217A (en) 2008-12-17 2010-09-16 Intervet Int Bv Process for making a crystalline zilpaterol salt
WO2012059807A1 (en) * 2010-11-02 2012-05-10 United Phosphorus Limited Chiral intermediates useful for the preparation of hydroxyphosphine ligands
WO2013171330A1 (en) 2012-05-18 2013-11-21 Intervet International B.V. A method of enhancing performance in broiler chickens
KR102214967B1 (ko) * 2012-12-18 2021-02-10 인터벳 인터내셔널 비.브이. 개선된 질파테롤 제조 공정
CN103554113B (zh) * 2013-09-25 2016-04-27 湖北美天生物科技有限公司 一种盐酸齐帕特罗的合成方法
WO2015174812A1 (es) * 2014-05-15 2015-11-19 Interquim, S.A. De C.V. Proceso mejorado para la preparación de zilpaterol
CN112662599B (zh) * 2021-01-27 2022-06-14 吉林省农业科学院 一株禽源贝莱斯芽孢杆菌cl-4及其应用
CN116675707A (zh) * 2023-04-25 2023-09-01 宜宾学院 一种合成齐帕特罗顺式光学异构体的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US514869A (en) * 1894-02-13 Smokeless boiler
FR2534257A1 (fr) * 1982-10-12 1984-04-13 Roussel Uclaf Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire
IT1185550B (it) 1985-04-12 1987-11-12 Dox Al Italia Spa Miscele non polverose di sfarinati o farine con principi attivi per mangimistica
HU203667B (en) * 1986-12-11 1991-09-30 Roussel Uclaf Process for producing synergetic zootechnical compositions containing three components
JP2915161B2 (ja) 1991-04-18 1999-07-05 三井化学株式会社 光学活性アミノアルコールおよびその中間体の製造方法
FR2735474B1 (fr) 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
EP0965574B1 (de) 1998-06-19 2004-10-13 Degussa AG Verfahren zur enantioselektiven Hydrierung
JP4618607B2 (ja) * 1999-07-30 2011-01-26 日本曹達株式会社 光学活性イミノアルコール類及びアミノアルコール類の製造法
MXPA05011392A (es) 2003-05-09 2005-12-12 Umicore Ag & Co Kg Ferrocenildifosfinas sustituidas, como ligaduras para catalizadores de hidrogenacion homogeneos.
WO2008006828A1 (en) 2006-07-10 2008-01-17 Intervet International B.V. Zilpaterol enantiomer compositions and methods of making and using such compositions
EP2079747B1 (en) 2006-10-13 2011-03-09 Pfizer Limited Heterocyclic compounds useful as anabolic agents for livestock animals
WO2008050207A1 (en) 2006-10-25 2008-05-02 Pfizer Limited Heterocyclic compounds useful as anabolic agents for livestock animals
CA2675651C (en) 2007-02-01 2012-10-02 Intervet International B.V. Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk] [1] -benzazepin-2 [1h] -one and zilpaterol

Also Published As

Publication number Publication date
IL199772A (en) 2013-08-29
KR20090108720A (ko) 2009-10-16
IL199772A0 (en) 2010-04-15
KR101150634B1 (ko) 2012-07-04
ZA200905103B (en) 2010-05-26
SI2109614T1 (sl) 2014-12-31
US20100173892A1 (en) 2010-07-08
CN101600719B (zh) 2013-06-12
RU2009132658A (ru) 2011-03-10
CA2675651C (en) 2012-10-02
AU2008209743A1 (en) 2008-08-07
JP5126626B2 (ja) 2013-01-23
EP2109614B1 (en) 2014-08-06
AU2008209743B2 (en) 2011-03-24
WO2008092924A1 (en) 2008-08-07
BRPI0807865A2 (pt) 2014-06-17
CA2675651A1 (en) 2008-08-07
US8629134B2 (en) 2014-01-14
CN101600719A (zh) 2009-12-09
RU2433131C2 (ru) 2011-11-10
EP2109614A1 (en) 2009-10-21
JP2010517968A (ja) 2010-05-27

Similar Documents

Publication Publication Date Title
MX2009008158A (es) Sintesis enantioselectiva de 6-amino-7-hidroxi-4,5,6,7-tetrahidro- imidazo[4,5,1-jk][1]-benzazepin-2[1h]-ona y zilpaterol.
IN2012DN04917A (es)
MX2010001126A (es) Proceso para la sintesis de inhibidores de enzima de activacion de e1.
NZ624063A (en) Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors
MY152386A (en) Substituted 6a,7,8,9-tetrahydropyrido[3,2-e] pyrrolo[1,2-a]pyrazin-6(5h)-ones
EP1887880A4 (en) PROCESS FOR PRODUCING ANIMAL FEED AND ETHANOL AND NEW FOOD
WO2010147898A3 (en) Small molecule inhibitors of spleen tyrosine kinase (syk)
CL2009000699A1 (es) Compuestos derivados de 6-heteroaril-imidazo[1,2-a]piridinas polisustituidas; composicion farmaceutica; procedimiento de sintesis; compuestos intermediarios; y su uso para tratar o prevenir enfermedades neurodegenerativas, psiquiatricas, inflamatorias, traumatismos cerebrales y de la epilepsia, osteoporosis, cancer, parkinson, entre otras.
IL185107A0 (en) Process for preparing cinacalcet hydrochloride
UA101493C2 (ru) Производные азетидина и циклобутана как ингибиторы jak
SG179120A1 (en) Novel compounds
MY161407A (en) 6,7-DIHYDRO-PYRAZOLO[1,5-a]PYRAZIN-4-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
MX2009010223A (es) Antagonistas del receptor de adenosina a2a.
MX2013003246A (es) Derivados de 4, 7-dihidro-pirazolo [1, 5-a] pirazin-6-ilamina utiles como inhibidores de beta-secretasa (bace).
MX340031B (es) Derivados de 3,4-dihidropirrolo[1,2-a]pirazin-1-ilamina utiles como inhibidores de beta-secretasa (bace).
EP2017250A4 (en) METHOD FOR PRODUCING THE PRODUCT OF HYDROGENOLYSIS OF ALCOHOLS CONTAINING MULTIPLE HYDROXYL GROUPS
IL185703A0 (en) Use of neuronal precursor cells for treatment of central nervous system lesions
EP2100868A4 (en) METHOD FOR PRODUCING THE PRODUCT OF HYDROGENOLYSIS OF ALCOHOLS CONTAINING MULTIPLE HYDROXYL GROUPS
CL2014000641A1 (es) Compuestos derivados de triazolo[1,5-a]piridina, inhibidores de la ped10a; proceso de obtencion; composicion farmaceutica; y uso en el tratamiento o profilaxis de enfermedades tales como esquizofrenia, parkinson, alzheimer, entre otras.
HUP0700395A2 (en) Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
IN2014KN02722A (es)
TW200611701A (en) Novel compounds
GB2459808B (en) Benzothiazole and benzoxazole linked pyrrolo [2,1-C] [1,4] benzodiazepine hybrids as novel antitumour agents and process for the preparation thereof
PL2342206T3 (pl) Sposoby uwodorniania pochodnych alkaloidów opiatowych
ZA200801186B (en) Process for the production of anilines

Legal Events

Date Code Title Description
FG Grant or registration