MX2009007008A - Peptido wt1 restringido a hla-a*1101 y composicion farmaceutica que comprende el mismo. - Google Patents
Peptido wt1 restringido a hla-a*1101 y composicion farmaceutica que comprende el mismo.Info
- Publication number
- MX2009007008A MX2009007008A MX2009007008A MX2009007008A MX2009007008A MX 2009007008 A MX2009007008 A MX 2009007008A MX 2009007008 A MX2009007008 A MX 2009007008A MX 2009007008 A MX2009007008 A MX 2009007008A MX 2009007008 A MX2009007008 A MX 2009007008A
- Authority
- MX
- Mexico
- Prior art keywords
- peptide
- hla
- ability
- pharmaceutical composition
- restricted
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000040856 WT1 Human genes 0.000 abstract 3
- 108700020467 WT1 Proteins 0.000 abstract 3
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 abstract 2
- 108010075704 HLA-A Antigens Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001152—Transcription factors, e.g. SOX or c-MYC
- A61K39/001153—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4242—Transcription factors, e.g. SOX or c-MYC
- A61K40/4243—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
Abstract
La presente invención se refiere a un péptido WT1 restringido a HLA-A*1101, específicamente un péptido que comprende una secuencia de aminoácidos que consiste en 9 aminoácidos contiguos provenientes de una proteína WT1, donde el péptido tiene la capacidad de unirse a una molécula HLA-A*1101 y tiene la capacidad de inducir un CTL; la presente invención también se refiere a un dímero de péptidos que tiene la capacidad de unirse a una molécula HLA-A*1101 y que tiene la capacidad de inducir un CTL, donde dos péptidos monómeros que comprenden cada uno una secuencia de aminoácidos que consiste en 9 aminoácidos contiguos de una proteína WT1 y que comprenden por lo menos un residuo de cisteína, se unen entre sí mediante un enlace bisulfuro; además, la presente invención se refiere a un polinucleótido que codifica el péptido, a una composición farmacéutica para el tratamiento y/o prevención de un cáncer que comprende el mismo y similares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006355356 | 2006-12-28 | ||
| PCT/JP2007/074146 WO2008081701A1 (ja) | 2006-12-28 | 2007-12-14 | Ｈｌａ－ａ＊１１０１拘束性ｗｔ１ペプチド、およびそれを含む医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009007008A true MX2009007008A (es) | 2009-07-10 |
Family
ID=39588385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009007008A MX2009007008A (es) | 2006-12-28 | 2007-12-14 | Peptido wt1 restringido a hla-a*1101 y composicion farmaceutica que comprende el mismo. |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US8653038B2 (es) |
| EP (6) | EP2098595A4 (es) |
| JP (1) | JP5484734B2 (es) |
| KR (1) | KR101525261B1 (es) |
| CN (5) | CN101573448B (es) |
| AR (1) | AR064555A1 (es) |
| AU (1) | AU2007340679B2 (es) |
| BR (1) | BRPI0720988A2 (es) |
| CA (5) | CA2886621A1 (es) |
| CY (1) | CY1116011T1 (es) |
| DK (3) | DK2479275T3 (es) |
| ES (4) | ES2526425T3 (es) |
| IL (4) | IL199052A0 (es) |
| MX (1) | MX2009007008A (es) |
| MY (1) | MY161664A (es) |
| NO (1) | NO20092774L (es) |
| NZ (4) | NZ592509A (es) |
| PH (1) | PH12014500902B1 (es) |
| PL (1) | PL2341142T3 (es) |
| PT (1) | PT2341142E (es) |
| RU (1) | RU2481398C2 (es) |
| SG (1) | SG177222A1 (es) |
| SI (1) | SI2341142T1 (es) |
| TW (3) | TWI417103B (es) |
| UA (1) | UA103154C2 (es) |
| WO (1) | WO2008081701A1 (es) |
| ZA (1) | ZA200903633B (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2071028T3 (pl) | 2003-11-05 | 2012-06-29 | Int Inst Cancer Immunology Inc | Pochodzący z WT1 peptyd antygenowy wiążący się z HLA-DR |
| EP2565201B1 (en) | 2005-10-17 | 2014-11-26 | Sloan-Kettering Institute For Cancer Research | WT1 HLA class II-binding peptides and compositions and methods comprising same |
| EP3117836A1 (en) | 2006-04-10 | 2017-01-18 | Sloan Kettering Institute For Cancer Research | Immunogenic wt-1 peptides and uses thereof |
| ES2559062T3 (es) | 2007-02-27 | 2016-02-10 | International Institute Of Cancer Immunology, Inc. | Método para la activación de linfocitos T colaboradores y composición para su uso en el método |
| AR083295A1 (es) | 2010-10-05 | 2013-02-13 | Univ Osaka | Metodo para activar celulas t auxiliares |
| JP6082997B2 (ja) * | 2011-04-01 | 2017-02-22 | メモリアル スローン−ケタリング キャンサー センター | Ｈｌａ−ａ２により提示されるｗｔ１ペプチドへのｔ細胞受容体様抗体 |
| EP2757373A4 (en) | 2011-09-14 | 2015-07-01 | Int Inst Cancer Immunology Inc | METHOD FOR MEASURING ANTI-WT1 ANTIBODIES |
| AU2013207669C1 (en) | 2012-01-13 | 2018-05-31 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| KR20150046346A (ko) | 2012-09-12 | 2015-04-29 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 항원 특이적 헬퍼 t 세포 리셉터 유전자 |
| CN105121715B (zh) | 2012-12-11 | 2018-10-26 | 艾伯特叶史瓦大学爱因斯坦医学院 | 高通量受体:配体鉴定方法 |
| KR102158225B1 (ko) | 2012-12-17 | 2020-09-21 | 오츠카 세이야쿠 가부시키가이샤 | 헬퍼 t세포의 활성화 방법 |
| PT2945647T (pt) | 2013-01-15 | 2020-11-26 | Memorial Sloan Kettering Cancer Center | Péptidos imunogénicos wt-1 e métodos de uso dos mesmos |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| RU2685933C2 (ru) | 2013-02-05 | 2019-04-23 | Нитто Денко Корпорейшн | Композиция противораковой вакцины, содержащая пептид wt1, для трансдермального введения |
| JP6497691B2 (ja) | 2013-02-05 | 2019-04-10 | 日東電工株式会社 | 粘膜投与用ｗｔ１ペプチド癌ワクチン組成物 |
| CN103961698A (zh) | 2013-02-05 | 2014-08-06 | 日东电工株式会社 | 经皮或粘膜给予用疫苗组合物 |
| KR20140100417A (ko) | 2013-02-05 | 2014-08-14 | 닛토덴코 가부시키가이샤 | 경피 투여용 백신 조성물 |
| KR20140099828A (ko) | 2013-02-05 | 2014-08-13 | 닛토덴코 가부시키가이샤 | 점막 투여용 백신 조성물 |
| EP2762155B1 (en) | 2013-02-05 | 2020-03-11 | Nitto Denko Corporation | Vaccine Composition |
| IN2014CH00393A (es) | 2013-02-05 | 2015-04-03 | Nitto Denko Corp | |
| US10449144B2 (en) | 2013-02-05 | 2019-10-22 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for transdermal administration |
| US10588952B2 (en) | 2013-03-29 | 2020-03-17 | Sumitomo Dainippon Pharma Co., Ltd. | Conjugate vaccine using trimming function of ERAP1 |
| WO2014157692A1 (ja) * | 2013-03-29 | 2014-10-02 | 大日本住友製薬株式会社 | Ｗｔ１抗原ペプチドコンジュゲートワクチン |
| KR102797324B1 (ko) * | 2014-12-11 | 2025-04-22 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 혈관 신생병의 면역 요법 |
| CA3022331A1 (en) | 2016-05-18 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Variant pd-l1 polypeptides, t-cell modulatory multimeric polypeptides, and methods of use thereof |
| CN109475628A (zh) | 2016-05-18 | 2019-03-15 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| EP3549957A4 (en) | 2016-11-30 | 2020-08-05 | Sumitomo Dainippon Pharma Co., Ltd. | AUXILIARY PEPTIDE WT1, AND COMBINATION OF DUDIT PEPTIDE AND CONJUGATE PEPTIDE ANTIGENIC FOR CANCER |
| AU2017379900B2 (en) | 2016-12-22 | 2024-12-05 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| WO2018129474A1 (en) | 2017-01-09 | 2018-07-12 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| EP3596118B1 (en) | 2017-03-15 | 2024-08-21 | Cue Biopharma, Inc. | Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer |
| CN111741972A (zh) * | 2017-12-27 | 2020-10-02 | 大日本住友制药株式会社 | Wt1衍生肽的缀合物和包含其的组合物 |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| DE112019001654B4 (de) | 2018-03-29 | 2024-10-17 | Rohm Co., Ltd. | Halbleiterbauteil |
| EP4149534A4 (en) | 2020-05-12 | 2024-09-04 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING T CELLS AND METHODS OF USE THEREOF |
| TW202200188A (zh) * | 2020-05-12 | 2022-01-01 | 日商大日本住友製藥股份有限公司 | 用以處置癌症之醫藥組合物 |
| WO2022056014A1 (en) | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4575374A (en) * | 1983-02-16 | 1986-03-11 | Anis Aziz Y | Flexible anterior chamber lens |
| US5763209A (en) * | 1988-09-26 | 1998-06-09 | Arch Development Corporation | Methods and materials relating to the functional domains of DNA binding proteins |
| US5584304A (en) * | 1993-11-18 | 1996-12-17 | Allergan, Inc. | Method of inserting an IOL using a forceps inside a folding tube |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5984962A (en) * | 1996-01-22 | 1999-11-16 | Quantum Vision, Inc. | Adjustable intraocular lens |
| US6207375B1 (en) * | 1996-12-11 | 2001-03-27 | Mayo Foundation For Medical Educational & Research | TGF-β inducible early factor-1 (TIEF-1) and a method to detect breast cancer |
| US20030235557A1 (en) * | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20030072767A1 (en) * | 1998-09-30 | 2003-04-17 | Alexander Gaiger | Compositions and methods for WT1 specific immunotherapy |
| BR9914116A (pt) * | 1998-09-30 | 2002-01-15 | Corixa Corp | Composições e métodos para imunoterapia especìfica de wt1 |
| US7063854B1 (en) * | 1998-09-30 | 2006-06-20 | Corixa Corporation | Composition and methods for WTI specific immunotherapy |
| US7144581B2 (en) * | 2000-10-09 | 2006-12-05 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20030039635A1 (en) | 1998-09-30 | 2003-02-27 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7115272B1 (en) | 1998-09-30 | 2006-10-03 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7655249B2 (en) * | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7901693B2 (en) | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| BR0009505A (pt) * | 1999-04-02 | 2002-06-11 | Corixa Corp | Compostos e processos para terapia e diagnóstico de câncer de pulmão |
| AU7859900A (en) * | 1999-10-04 | 2001-05-10 | Corixa Corporation | Compositions and methods for wt1 specific immunotherapy |
| US20030082194A1 (en) | 2000-02-22 | 2003-05-01 | Alexander Gaiger | Compositions and methods for diagnosis and therapy of malignant mesothelioma |
| CA2401070A1 (en) * | 2000-02-22 | 2001-08-30 | Corixa Corporation | Compositions and methods for diagnosis and therapy of malignant mesothelioma |
| US20040097703A1 (en) * | 2001-03-22 | 2004-05-20 | Haruo Sugiyama | Wt1 modified peptide |
| IL145015A0 (en) * | 2001-08-21 | 2002-06-30 | Nun Yehoshua Ben | Accommodating lens |
| US7553494B2 (en) * | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
| JP4365784B2 (ja) | 2002-06-12 | 2009-11-18 | 株式会社癌免疫研究所 | Ｈｌａ−ａ２４拘束性癌抗原ペプチド |
| JP4377323B2 (ja) | 2002-06-14 | 2009-12-02 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
| SE0201863D0 (en) * | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| ES2332590T3 (es) * | 2003-01-15 | 2010-02-09 | International Institute Of Cancer Immunology, Inc. | Dimero peptidico. |
| US7976520B2 (en) * | 2004-01-12 | 2011-07-12 | Nulens Ltd. | Eye wall anchored fixtures |
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| JP2006045287A (ja) | 2004-08-02 | 2006-02-16 | Inax Corp | 弾性接着剤及びタイル張り壁面 |
| JP4719876B2 (ja) * | 2005-04-04 | 2011-07-06 | 国立大学法人愛媛大学 | Ｈｌａクラスｉｉ拘束性ｗｔ１抗原ペプチド |
| US20110318380A1 (en) * | 2008-10-01 | 2011-12-29 | Dako Denmark A/S | MHC Multimers in Cancer Vaccines and Immune Monitoring |
-
2007
- 2007-12-14 CN CN2007800487491A patent/CN101573448B/zh not_active Expired - Fee Related
- 2007-12-14 PT PT101912343T patent/PT2341142E/pt unknown
- 2007-12-14 BR BRPI0720988-6A patent/BRPI0720988A2/pt active Search and Examination
- 2007-12-14 CN CN2011102355279A patent/CN102295682A/zh active Pending
- 2007-12-14 CN CN201110235503.3A patent/CN102302788B/zh active Active
- 2007-12-14 SG SG2011094588A patent/SG177222A1/en unknown
- 2007-12-14 DK DK12164855.4T patent/DK2479275T3/en active
- 2007-12-14 PL PL10191234T patent/PL2341142T3/pl unknown
- 2007-12-14 CA CA 2886621 patent/CA2886621A1/en not_active Abandoned
- 2007-12-14 NZ NZ592509A patent/NZ592509A/xx not_active IP Right Cessation
- 2007-12-14 ES ES10191234.3T patent/ES2526425T3/es active Active
- 2007-12-14 NZ NZ577443A patent/NZ577443A/en not_active IP Right Cessation
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