MX2009006003A - Composicion que contiene derivados de aurona con fines de diagnostico. - Google Patents
Composicion que contiene derivados de aurona con fines de diagnostico.Info
- Publication number
- MX2009006003A MX2009006003A MX2009006003A MX2009006003A MX2009006003A MX 2009006003 A MX2009006003 A MX 2009006003A MX 2009006003 A MX2009006003 A MX 2009006003A MX 2009006003 A MX2009006003 A MX 2009006003A MX 2009006003 A MX2009006003 A MX 2009006003A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- diagnosis
- amyloid
- containing composition
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K51/0419—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Furan Compounds (AREA)
Abstract
Una composición para el diagnóstico de una enfermedad relacionada con amiloides, que comprende un compuesto representado por la fórmula general (I): (ver fórmula (I)) en donde X representa O o semejantes; R1, R3, R4, R5, R6, R8 y R9 representan un átomo de hidrógeno o semejantes; R2 representa un átomo de halógeno o semejantes; y R7 representa un grupo dimetilamino o semejantes; o el compuesto marcado con un radionúclido, o una sal farmacéuticamente aceptable del compuesto o del compuesto marcado. El compuesto representado por la fórmula general (I) presenta todas las siguientes propiedades: gran especificidad de unión a la proteína ß-amiloide, gran permeabilidad a través de la barrera hematoencefálica y depuración rápida de los sitios sin placas seniles en el cerebro.A2.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006328131 | 2006-12-05 | ||
| JP2007081602 | 2007-03-27 | ||
| PCT/JP2007/070930 WO2008068974A1 (ja) | 2006-12-05 | 2007-10-26 | オーロン誘導体含有診断用組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009006003A true MX2009006003A (es) | 2009-06-17 |
Family
ID=39491885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009006003A MX2009006003A (es) | 2006-12-05 | 2007-10-26 | Composicion que contiene derivados de aurona con fines de diagnostico. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100003191A1 (es) |
| EP (1) | EP2113258A1 (es) |
| JP (1) | JPWO2008068974A1 (es) |
| KR (1) | KR20090087037A (es) |
| AU (1) | AU2007330190A1 (es) |
| BR (1) | BRPI0719689A2 (es) |
| CA (1) | CA2671596A1 (es) |
| IL (1) | IL198918A0 (es) |
| MX (1) | MX2009006003A (es) |
| RU (1) | RU2009125612A (es) |
| WO (1) | WO2008068974A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8193363B2 (en) * | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
| MX372914B (es) | 2015-06-16 | 2020-04-27 | Jiangsu Hengrui Medicine Co | Derivado de piperidina y metodo de preparacion y uso farmaceutico del mismo. |
| WO2017180644A1 (en) | 2016-04-11 | 2017-10-19 | Middle Tennessee State University | Therapeutic aurones |
| CN117720541A (zh) * | 2018-03-09 | 2024-03-19 | 里科瑞尔姆Ip控股有限责任公司 | 取代的1,2-二氢-3H-吡唑并[3,4-d]嘧啶-3-酮 |
| JP7204568B2 (ja) * | 2018-04-04 | 2023-01-16 | 株式会社Cics | アミロイドβ疾患のホウ素中性子捕捉療法用化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130305D0 (en) * | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
| CN100537559C (zh) * | 2006-06-14 | 2009-09-09 | 浙江大学 | 类黄酮衍生物及其制备方法和用途 |
-
2007
- 2007-10-26 MX MX2009006003A patent/MX2009006003A/es not_active Application Discontinuation
- 2007-10-26 CA CA002671596A patent/CA2671596A1/en not_active Abandoned
- 2007-10-26 WO PCT/JP2007/070930 patent/WO2008068974A1/ja not_active Ceased
- 2007-10-26 KR KR1020097011572A patent/KR20090087037A/ko not_active Withdrawn
- 2007-10-26 BR BRPI0719689-0A2A patent/BRPI0719689A2/pt not_active IP Right Cessation
- 2007-10-26 AU AU2007330190A patent/AU2007330190A1/en not_active Abandoned
- 2007-10-26 RU RU2009125612/15A patent/RU2009125612A/ru not_active Application Discontinuation
- 2007-10-26 US US12/517,159 patent/US20100003191A1/en not_active Abandoned
- 2007-10-26 EP EP07830664A patent/EP2113258A1/en not_active Withdrawn
- 2007-10-26 JP JP2008548198A patent/JPWO2008068974A1/ja active Pending
-
2009
- 2009-05-25 IL IL198918A patent/IL198918A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008068974A1 (ja) | 2008-06-12 |
| CA2671596A1 (en) | 2008-12-06 |
| RU2009125612A (ru) | 2011-01-20 |
| AU2007330190A1 (en) | 2008-06-12 |
| EP2113258A1 (en) | 2009-11-04 |
| BRPI0719689A2 (pt) | 2013-12-24 |
| US20100003191A1 (en) | 2010-01-07 |
| KR20090087037A (ko) | 2009-08-14 |
| IL198918A0 (en) | 2011-08-01 |
| JPWO2008068974A1 (ja) | 2010-03-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |